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Biomedical subjects

J P Bapat

Publications and source records attributed to J P Bapat.

At least 19 recordsLinked to original sources

Hereditary high-adenosine triphosphate syndrome: study of a new variant.

A new variant of hereditary hemolytic anemia in a family due to high adenosine triphosphate (ATP) is reported. The increase in ATP levels varied from 83 to 105% in the family members. Low 2,3-diphosphoglycerate levels and low 2,3-diphosphoglyceromutase activity were observed in three family members, with normal glucose-6-phosphate dehydrogenase and pyruvate kinase activity.

Adenosine Triphosphate↗

Associated red cell enzyme deficiencies and their significance in a case of congenital enzymopenic methemoglobinemia.

Examination of the red cell enzyme profile in a case of congenital methemoglobinemia has shown associated deficiencies of glutathione reductase (GR) and glutathione peroxidase (GSHPx) in addition to NADH-methemoglobin reductase deficiency. Contrary to expectations, GR and GSHPx deficiencies do not seem to have contributed to the methemoglobinemia in this case. The lack of symptoms in spite of a high methemoglobin (Hi) level (35%) appears to be due to the restriction of Hi to a small percentage of red cells.

Adult↗

Distribution of subtypes of hepatitis B surface antigen in Western India.

HBsAg subtype distribution of 105 positive samples showed 91.4% as ay type. The ay was predominant in different disease conditions, healthy carriers and posttransfusion hepatitis. The prevalence of ay in the Bombay sample is in contrast to the predominance of ad reported from North India. These findings may suggest multifocal infection in different regions of India.

Carrier State↗

Genetic studies among the endogamous groups of Lohanas of North and West India.

Four groups of Lohanas, belonging to the Gujarati, Sindhi and Punjabi were studied for various genetic markers. Lohanas have higher B than A and low Rh(D) negative (1.65-4.64%). The Hp1 gene ranges from 0.1557 to 0.2639; Gm1 is lower (0.34-0.55) than in other populations in Southern India. G-6-PD deficiency was prevalent in 3-8%. All the four groups have a high incidence of the thalassaemia trait and possess Hb-D. Hb, J, and L were also observed in two groups. Data was analysed for intergroup differences.

ABO Blood-Group System↗