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Biomedical subjects

J P Barnes

Publications and source records attributed to J P Barnes.

12 recordsLinked to original sources
PubMed1995

The distribution of electron trapping in DNA: one-electron-reduced oligodeoxynucleotides of adenine and thymine.

A series of single- and double-stranded oligodeoxynucleotides of adenine and thymine, 8 to 12 nucleotides in length, were one-electron-reduced at 10 K in a > 8 M LiCl/H2O glass. The Q-band electron paramagnetic resonance (EPR) spectra of these radicals show that thymine is the dominant trapping site for mobile electrons in these oligomers. The spectra of the reduced oligomers in the series pd(AnT10-n).pd(A10-nTn) with n = 5-->10 showed a trend which is interpreted as either an increase in the probability of trapping at an adenine base in tracks of adenine > 7 base pairs in length, or the presence of different protonated states of the one-electron-reduced bases due to the adoption of a different conformational state for longer tracks of adenine, or a combination of these two possibilities. Analysis of the trends in the EPR spectra of the radicals as a function of sequence using multicomponent analysis is presented.

Adenine Nucleotides↗
PubMed1990

Recurrent inguinal hernia in relation to ideal body weight.

The records of 686 patients who underwent herniorrhaphy for primary or initially recurrent inguinal hernia during the years 1975 through 1985 were reviewed. Patients were divided into groups according to percentage of ideal body weight. Analysis showed that, compared with the patients with primary hernia, a larger proportion of patients with recurrent hernia were near or below ideal body weight. A follow-up survey of 64 patients who underwent primary repair of hernia indicated that the percentage of ideal body weight of a patient had no apparent effect on the recurrence rate of inguinal hernia.

Adult↗
PubMed1987

Inguinal hernia repair with routine use of Marlex mesh.

An analysis of an 11 year experience with the routine use of Marlex (polypropylene) mesh reinforcement of the canal floor in both indirect and direct inguinal herniorraphy is presented. All patients in good general health were accepted regardless of their age or weight. Survey responses were obtained from a large and representative sample of this experience. The results of this series demonstrate that Marlex mesh is well tolerated in the inguinal canal and that the recurrence rates are low for both direct and indirect inguinal hernias. In particular, there were no recurrences in patients less than 60 years of age and no recurrence in patients weighing less than 185 kilograms. The average weight of patients with a recurrence was 92 kilograms and the average age was 72 years old. Several possible ways to improve the technique are discussed.

Adult↗
PubMed1975

Joining gut ends of unequal diameter.

A simple, safe and precise method for joining ends of unequal diameter is presented. Very little septum is created by either anterior or posterior rows. The figure-eight seems to crush the septum almost flat on the posterior row and the Halsted's create an absolutely minimal septum anteriorly where they are correctly placed. The posterior row used two layers of submucosa and the anterior one, four layers, and no reliance is placed on the serosa-muscularis layer. This technique is thought to have distinct advantages relative to strength, safety, and minimal septum formation.

Humans↗