[Splenic infarct as the etiology of acute abdomen].
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Abdomen, Acute↗
Biomedical subjects
J P Barras
Publications and source records attributed to J P Barras.
Calcium dobesilate: pharmacological profile related to its use in diabetic retinopathy.
Calcium dobesilate (Doxium) is used in the treatment of diabetic retinopathy. Clinical studies show a slowdown of the progression of the disease after long-term oral treatment. The main action of the drug is related to a reduction of microvascular permeability as measured by different parameters and methods (vitreous fluorophotometry, retinal haemorrhages, skin capillary resistance, blood albumin leakage, blood viscosity) leading to improved visual acuity. The pharmacological activity may be explained in part by the antioxidant properties of calcium dobesilate and its action on endothelium through the synthesis of nitric oxide, increasing the endothelium-dependent relaxation. The antioxidant effect was demonstrated in different in vitro and in vivo models by decreasing the peritoneal permeability in rats induced by pro-oxidant substances. Moreover, vascular leakage was also decreased by calcium dobesilate in a reperfusion model in streptozotocin induced diabetic rats after ischaemia of the central artery of the retina. Doxium may also preserve vascular endothelial function by acting directly as antioxidant to protect lipids from peroxidation.
Animals↗
[Surgical therapy of mesenteric infarct].
Acute mesenteric infarction represents less than 1-2% of all surgical emergencies but is responsible for many lethal events. A successful management requires very efficient diagnostic and therapeutic measures. Cases with established bowel infarction are associated with a mortality rate of 80-90% since years. In the last 10 years some hospitals offering an aggressive pre-, per- and postoperative multimodal therapy could reduce the mortality in selected series to 50-60%. One of the most important factors to reduce the mortality is beneath early diagnosis the emergency angiography and the angiography-associated treatment like intraarterial application of vasodilators, even in occlusive forms of mesenteric infarction. But this concept is seldom applicable to small hospitals because of the partially lacking availability of angiography. We present a concept of treatment taking into account this fact. Generous indication for emergency laparotomy in patients suspect of acute mesenteric ischemia is the central pillar of our concept. We also plea for a very restraint indication in biologically old multimorbid patients presenting a sum of negative prognostic factors and consider in these cases the reluctant attitude as an ethically and medically positive behaviour.
Acute Disease↗
Isolated late metastasis of a renal cell cancer treated by radical distal pancreatectomy.
A 53-year-old man underwent right nephrectomy for a locally renal cell carcinoma with concomitant resection of a solitary metastasis in the right lung. Ten years later, he presented with haematochezia caused by a tumour in the tail of pancreas, invading the transverse colon and the greater curvature of the stomach. The tumour was radically resected, and histological examination revealed a solitary metastasis of the previous renal cell carcinoma. This case illustrates a rare indication for pancreatic resection because of pancreatic metastasis.
Carcinoma, Renal Cell↗
Is there still a place for abdominoperineal resection of the rectum?
During the past two decades, low anterior resection (LAR) with colo-rectal or colo-anal anastomosis has replaced abdominoperineal resection (APR) as the primary surgical therapy for rectal cancer. Several studies, although not prospectively randomized, have shown that the outcome after LAR with deep anastomosis and APR is comparable concerning mortality, local recurrence rate and survival. Adequate clearance of the tumour, and not the surgical procedure performed, is the determinant factor influencing the outcome. Whereas most tumours in the upper third and mid-rectum are amenable to a sphincter-saving procedure (SSP), the lower third of the rectum is of debate in this respect. Small tumours (T1) in the lower third can be treated by peranal local excision. Low grade tumours with a T2 or T3 stage located above 3 cm from the dentate line are treated by SSP. There is still a place for for advanced tumours (T3 and T4) below 5 cm from the anal verge, in case of deficiency of the anal sphincter, and when the sphincter complex is infiltrated by the tumour. Preoperative staging measures are essential for patients selection in relation to height of the tumour above the anal canal, depth of tumour invasion into the rectal wall, and presence or absence of regional lymph node metastases. Biology of rectal cancer and its implication on surgery, preoperative staging of rectal cancer, technique and results of the main three surgical options, and the advent of laparoscopy are discussed in this article.
Abdomen↗
[Laparoscopic cholecystectomy in morbid obesity].
In the early days of laparoscopic cholecystectomy (LC) morbid obesity was considered a relative contraindication for this procedure. With increased experience the procedure has been used in obese patients too. To evaluate the influence of morbid obesity on feasibility and outcome of LC, we performed a prospective study in 136 patients in whom LC was attempted between January 1991 and January 1992. Conversion to open cholecystectomy was necessary in 26 cases (19%). The remaining patients were divided into two groups. Group 1 consisted of 92 normal or slightly obese individuals, whereas 18 morbidly obese patients were included in group 2. Intraoperative problems (42% vs 61%) and postoperative morbidity (2% vs 11%) were less frequent in group 1, although not statistically significant. There was no difference in operating time (median for both groups: 110 minutes) and length of hospital stay (4 days). The incidence of late complications (3% vs 6%) was similar. We conclude that LC in morbidly obese patients, as in open surgery, is technically more demanding than in normal individuals. The operative risk was elevated (p < 0.05) as evidenced by a tendency to higher intra- and postoperative complication rates. Cholecystolithiasis in morbidly obese patients is a good indication for LC in the hands of well trained laparoscopic surgeons who are ready to convert to open surgery if problems arise.
Adult↗
[Effect of rejuvenation on the rheologic properties of stored erythrocytes].
Buffycoat free red cell concentrates in a medium composed of sodium chloride, adenine, glucose and mannitol (SAGM) stored for 42 days at +4 degrees C were rejuvenated by a solution which contained pyruvate, inosine, disodiumphosphate and adenine (PIPA). The rheological behaviour of red cells was measured before and after rejuvenation by viscosimetry of red cell suspensions (hematocrit 45%) at various intervals during the storage period. The deformability of the red cells during storage was determined also before and after rejuvenation by measurement of the viscosity of hard packed cells (hematocrit 98%). The results show improvement of the rheological properties by rejuvenation. Moreover it is shown that incubation of the red cells at 37 degrees C for two hours without rejuvenation solution decreases the viscosity.
Adenine↗
[Low anterior resection versus rectum amputation for treatment of rectal cancer].
In the controversy whether abdominoperineal resection of sphinctersaving resection is more radical for the treatment of lower rectal cancer, 77 consecutive patients with rectal cancer were retrospectively analysed. All resections were curative. 40 patients underwent a low resection and 37 patients an abdomino-perineal resection. Both groups were comparable with regard to age, sex and especially tumor-stage. The crude 5-year survival-rates were 52.5% in the resection group and 54.1% in the amputation group, respectively. The patients with a carcinoma located within 5-10 cm from the anal verge were of special interest. The crude 5-year survival-rates in these special subgroups were 61.9% for the sphinctersaving procedure and 61.5% for the amputation group, respectively. We conclude that the choice of surgical procedure does not influence the prognosis in rectal cancer, in particular, sphinctersaving resection does not worsen the prognosis. Therefore, whenever technically possible, the sphincter-saving resection should be chosen to cure rectal cancer.
Aged↗
[Secondary peritonitis after negative computerized tomography in blunt abdominal trauma].
Diagnostic peritoneal lavage has widely been replaced by emergency sonography in the evaluation of blunt abdominal trauma. CT is generally performed in cases without major hemodynamic instability in order to define non-operative treatment of injuries of the parenchymatous organs or to precise the extension of retroperitoneal, spinal and pelvic lesions. Despite the good results of this method for the mentioned indications, the low sensitivity of CT for lesions of hollow viscus should not be forgotten. We report 3 cases of lesions of the small bowel (2 perforations and 1 mesenteric lesion with ischemic bowel wall) which were not visible, even retrospectively, at the CT. Despite discrete clinical signs, these lesions were only diagnosed at the stage of obvious secondary peritonitis. These cases should remind us the limits of CT in the evaluation of abdominal visceral lesions in blunt trauma.
Abdominal Injuries↗
[Diagnostic surprises in apparently inflammatory masses of the right iliac fossa].
Most patients presenting an inflammatory mass of the right iliac fossa have a medical history suggestive of an acute appendicitis the weeks before and further investigations will confirm the diagnosis of an appendicular abscess. During the last 2 years, we have investigated and treated seven adults presenting such a mass. In a diagnostic purpose, but in way to treat the suspected abscess in the acute phase with a percutaneous drainage too, we have performed a CT of the abdomen and of the pelvis in every case. Only 3 of 7 patients had in fact a true appendicular pathology. One patient had a cecal diverticulitis with severe peri-diverticulitis, 3 other patients had a malignant lesion developed from a small intraluminal tumor but with a wide extension outside the limit of the cecum. These examples show that careful investigations are mandatory in all cases of apparent inflammatory mass of the right iliac fossa.
Abscess↗
[Status of portal perfusion in colorectal cancer. Swiss Study Group for Clinical Cancer Research].
533 patients with diagnosis of operable colorectal carcinoma were randomized to receive either a single course of portal infusion with Mitomycin-C (MMC) and 5-Fluorouracil (5-FU) starting immediately after operation, or no adjuvant treatment. Of these, 505 (94%) were evaluable. Over the median follow-up of 8 years, the adjuvant therapy reduced the risk of recurrence by 22% (Hazard ratio = 0.78%, 95% CI 0.61-0.99; P = 0.045). The relative reduction of relapse on death was similar in all subgroups (i.e. nodal status, localization). However, adjuvant portal chemotherapy proved to be most efficient in the subgroups of patients with tumor involvement of the regional lymph nodes (Dukes C) and of patients with colon cancer. Analysis of the pattern of relapse showed that most of the difference in overall and disease-free survival is to be attributed to a consistent reduction of all kinds of tumor recurrences (i.e. local relapses, liver metastases and/or other distant metastases) in the treated group, rather than to liver relapses alone. We conclude therefore, that part of significant benefit obtained for patients with operable colorectal carcinoma treated with a single course of adjuvant chemotherapy via the portal vein might be due to the additional systemic effects of the portal chemotherapy and further study of perioperative treatment with and without prolonged chemotherapy appears worthwhile.
Adenocarcinoma↗
Pattern of recurrence in rectal carcinoma: implications for the design of (future) studies on adjuvant therapy.
255 patients who underwent potentially curative surgical treatment for rectal carcinoma at the Cantonal Hospital Aarau from 1981 to 1989 have been followed up and the results analysed for overall survival and the timing and occurrence of local and distant recurrence in relation to the initial tumor stage. The patients had received standard surgical treatment for rectal carcinoma with the exception of 28 patients who had been randomized to the treatment arm of SAKK protocol 40/81 and were given perioperative adjuvant portal chemotherapy. 10 patients with large fixed tumors had preoperative radiation therapy. In UICC stage I most patients were cured by surgery alone, local recurrence as rare, and distant metastases appear in about 10% of pT2. cases. In stage II about one fifth of the patients developed a recurrence with one third of them having only local recurrence, and two thirds having either combined local and distant recurrence or distant recurrence alone. The small subgroup of pT4 pN0 had a very poor prognosis with early occurrence of distant metastases. In stage III the actuarial five-year survival was 25%, 60% of stage III cases had pN1 nodal disease. No patient with pN2-3 disease was alive after five years follow-up. The overall risk of distant metastases in stage III was 64%. Local recurrence rate was highly dependent on the pT-stage.(ABSTRACT TRUNCATED AT 250 WORDS)
Adenocarcinoma↗
A rare complication of the use of a finger cot to protect the cuff of a tracheal tube during nasotracheal intubation.
Some anesthetists in Switzerland and elsewhere use a finger cot to protect the cuff of the endotracheal tube during nasotracheal intubation. In the presented report the finger cut was lost during the procedure and the patient presented 3 months later with a lateral neck mass. The finger cot was found within that mass at exploration. Apart from the other potential risks of this manoeuvre, this severe complication should incite caution against the practice described above.
Aged↗
[Whipple's operation for tumors of the pancreatic head and periampullar area].
Between 1986 and 1991 35 partial duodenopancreatectomies have been performed in the Clinic for visceral surgery of the University of Berne. 17 for adenocarcinoma of the pancreas and 18 for miscellaneous malignant or semimalignant pathologies such as ampullary or duodenal carcinomas, cystadenomas and distal bile duct carcinomas. The mortality was 5%. Postoperative complication was observed in 50% of cases. Leak at the pancreaticojejunal anastomosis was the most common surgical complication but healed under conservative treatment with somatostatin within few days in 5 of 6 cases. The median survival for patients with adenocarcinoma of the pancreas is 550 days, for patients with other pathologies 1200 days with some long-term survival in ampullary carcinomas. These results show on one hand that this kind of surgery can be realized with acceptable morbidity and mortality rate, on the other hand that further clinical trials in systemic adjuvant treatment are indicated especially in pancreatic cancer to improve the disappointing long-term results.
Adenocarcinoma↗
[Massive hemorrhage from presacral veins during resection of the rectum].
During the last 53 abdominoperineal amputations of the rectum for carcinoma, we had to control 5 massive hemorrhages. 4 of which were due to a lesion of the presacral venous plexus and caused a mean blood-loss of 4750 ml. During a "normal" Mile's operation our 49 other patients lost an average of 1750 ml (median 1200 ml) of blood. The negative effects of this type of complication and the following need for massive transfusion is not only local, circulatory and pulmonary, but also due to the immunodepressive effects of massive transfusion. We describe the different methods of control of these hemorrhages and insist on the advantage of using sterilised metallic thumbtacks, a method which was described 1984 by doctor Wang Qinyao of Shanghai.
Blood Loss, Surgical↗
[The pattern of recurrence of T3 rectum cancer].
Rectal carcinoma is one of the most common tumors of the GI-tract. At the time of initial treatment the majority of our patients had a stage T3 tumor. In order to contribute to the development of new guidelines for adjuvant therapies we analysed the patterns of recurrence in the patients operated with curative intention in our institution between 1981 and 1989. The pattern of recurrence shows that every fifth patient could benefit of a local measure to reduce local recurrence and that every second patient with positive nodal histopathology could benefit of a systemic adjuvant chemotherapy.
Adenocarcinoma↗
[Sequelae of venous thrombosis. Incidence in of the post-thrombosis syndrome after 5 years].
The authors report on an epidemiological study carried out in Basle, Switzerland, which prospectively included 341 consecutive patients (226 men, 115 women, mean age 52 +/- 16 years) who had developed deep venous thrombosis evidenced by phlebography. The treatment of the acute phase most often consisted in thrombolysis, conventional heparin being reserved for the contra-indications of thrombolysis. A second phlebographic examination allowed dividing up the series into two groups, ie. positive and negative, according to the presence or absence of a complete or partial return of patency. Each group was subdivided according to the location and extension of the thrombosis. Both groups (positive vs. negative) are different as regards the location and extent of the thrombosis. The selective comparison of both groups according to the objective subdivision demonstrated: the absence of post-phlebitis disease in sural phlebitis; the same risk of post-phlebitis disease in thrombosis extending to 4 levels, whether patency was restored or not; lower incidence of post-phlebitis disease in the positive group for single -, two - or three-level phlebitis. Leg ulcers occur within an average of 5.5 +/- 2.1 years after the acute episode in 6.7% of all patients. Complete return of patency is obtained in 23% of cases only.
Adult↗
[Transarticular amputation at the knee in peripheral arterial occlusive disease. Very positive experiences after routine use of the Klaes and Eigler technique].
In a retrospective study we compare our experience with the through-knee amputation in peripheral vascular disease. In the first 15 patients we used an amputation technique with circular incision. In about 50% of these patients we observed a delayed wound healing or they needed a reamputation to a higher bony level. In the 17 following patients we used the amputation technique described by Klaes and Eigler, using a posterior myocutaneous flap to cover the condyles. Only one of these patients needed a reamputation and another had a secondary wound healing. We conclude that the technique of through-knee amputation described by Klaes and Eigler is better adapted for patients with peripheral vascular disease.
Aged↗