Biomedical subjects

J P Bernstein

Publications and source records attributed to J P Bernstein.

3 recordsLinked to original sources

PubMed1984

Dynamics of the cortisol suppression index in depression.

The cortisol suppression index (CSI), a ratio of predexamethasone to postdexamethasone plasma cortisol levels, has been suggested as an alternate approach to the use of the DST in the diagnosis of depression. Forty-eight psychiatric inpatients were prospectively studied to compare the utility of the CSI to results obtained using Carroll's fixed values at 4 p.m. and 11 p.m. Eighty-eight percent (22/25) of depressed patients had an 8 a.m. CSI below 7.0; 73% (16/22) had a 4 p.m. CSI less than 2.5. This compared to a 76% detection rate using Carroll's criteria for nonsuppression. In this study the CSI provided a sensitive and specific interpretation of the dexamethasone suppression test in depression.

Adolescent↗

PubMed1982

Cortisol suppression index.

Explore the source record for details and available documents.

Depressive Disorder↗

PubMed1982

Cortisol suppression index: a new approach to interpreting the DST in depression.

The cortisol suppression index (CSI) is a ratio of pre- to postdexamethasone plasma cortisol concentrations. In a sample of 24 psychiatric inpatients, an 8 a.m. CSI detected 66% of patients with major depression. Further studies with larger samples and additional controls, including normal subjects, are suggested to validate these prospective findings. This index may serve as a useful and more practical way of detecting major depression in outpatients.

Adult↗