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J P Boiteux

Publications and source records attributed to J P Boiteux.

At least 19 recordsLinked to original sources
PubMed2001

Minimally invasive extraperitoneal lymphadenectomy: clinical validation of an original technique.

PURPOSE: To validate an original technique described for pelvic node dissection. PATIENTS AND METHODS: A series of 192 patients were included in this study. The surgical technique we reported in 1987 is based on the use of a special retractor called the pelvioscope. The incision is the classical MacBurney incision on the right and its equivalent on the left. After the division of the muscles, the peritoneum is mobilized medially, and the pelvioscope is introduced. The node resection is then performed with classical surgical instruments. RESULTS: In total; 151 bilateral, 20 unilateral right, and 21 unilateral left node dissections have been performed. In one case, dissection was not possible on both sides, and in two cases, the dissection was not complete on one side (patients previously operated on). The average intraoperative time was 69 minutes for a unilateral procedure and 103 minutes for a bilateral procedure. The mean number of pelvic lymph nodes removed was 5.6 on each side. The overall rate of complications was 7.3%. CONCLUSION: The effectiveness of this minimally invasive surgery is clear, and the morbidity is low.

Adult↗
PubMed2000

[Nutrition and prostatic cancer].

Due to the major geographical variations affecting its clinical incidence, prostate cancer appears to be influenced by environmental factors, which may either promote or inhibit the development of this tumour. Diet appears to play a considerable role among these environmental factors. There are epidemiological and experimental arguments in favour of the role of diet in the development of prostatic cancer. Certain foods, such as fats, phenolic compound and other micronutrients such as vitamins or selenium have been reported to have an action on the natural history of prostate cancer. The authors present a review of the literature analysing the various potential actions of various foods.

Diet↗
PubMed1999

[Human ejaculation: physiology, surgical conservation of ejaculation].

OBJECTIVE: The most widely accepted theory to explain ejaculation consists of two phases: 1) A phase of accumulation of the various constituents of semen inside the prostatic urethra. 2) A phase of expulsion with opening of the striated sphincter, while the smooth sphincter of the bladder neck remains closed. The objective of this study was therefore to confirm or invalidate this hypothesis. MATERIAL AND METHODS: Eight volunteers were studied by continuous transrectal ultrasonography allowing dynamic analysis of ejaculation. Sixteen patients presenting with a bladder neck obstruction syndrome were treated by a technique preserving the last centimetre of supramontanal urethra. RESULTS: In the eight healthy subjects, we constantly and successively observed: filling of the ejaculatory ducts. prostatic contractions. Expulsion of the contents of the seminal vesicles into the inframontanal urethra, without prior ballooning of the prostatic urethra. In the 16 patients treated for bladder neck obstruction, we did not observe any case of retrograde ejaculation.

Adult↗
PubMed1999

[Traumatic dislocation of the testis. Report of three cases].

The authors report three cases of traumatic dislocation of the testis. Each case concerned a young patient, victim of a motorbike accident with direct trauma to the perineum and scrotum on the reservoir. Preoperative radiological assessment consisted of ultrasound, computed tomography, or even magnetic resonance imaging, depending on the case. Surgical exploration revealed 3 traumatic dislocations of the testis, including one with associated torsion of the spermatic cord. One case also presented fracture of the contralateral testis, which was not dislocated. Each case was repaired by repositioning of the testis in the scrotum. The fractured testis could not be preserved. A review of the literature confirmed the rarity of these traumatic lesions. Dislocations are usually inguinal, sometimes bilateral, and can be ectopic. Spermatic cord lesions may also be associated. The authors define the place of radiological assessment, which can guide the diagnosis and therapeutic strategy. Surgical exploration, allowing assessment of the lesions, is required in every case. Repositioning of the testis in the scrotum ensures cure when the testis is still viable.

Accidents, Traffic↗
PubMed1999

[Value of Führman's nuclear grade: comparison with other prognostic factors of renal epithelial tumors].

OBJECTIVE: To assess the prognostic value of Führman's nuclear grade and to compare it to various clinical and histological prognostic factors of renal carcinomas. PATIENTS AND METHOD: Single-centre retrospective study of 102 patients operated for renal tumours between January 1985 and December 1990 (mean follow-up: 8.2 years). Prognostic assessment was studied from survival curves. RESULTS: The prognostic factors most closely correlated with survival were, in decreasing order, metastatic invasion, nuclear grade, stage of local extension and lymph node invasion. A significant (p < 0.01) survival difference was only observed between Führman grade 2 and grade 3 tumours. This difference was accentuated (p < 0.001) when grade 1 and 2 tumours were compared to grade 3 and 4 tumours. Führman's nuclear grade is independent of the side affected, the tumour volume, its multifocal nature, microscopic venous invasion and metastatic invasion at the time of diagnosis. Führman's nuclear grade is correlated with invasion of fat, the presence of a contingent of eosinophilic cells, stage of local extension, lymph node invasion and the subsequent development of metastases. CONCLUSION: This study confirms the importance of Führman's nuclear grade among the various prognostic factors of renal carcinomas and quantifies its value with respect to other prognostic factors.

Adult↗
PubMed1998

Human bladder cancers and normal bladder mucosa present the same hot spot of heterozygous chromosome-9 deletion.

Loss of heterozygosity (LOH) on chromosome 9 is the most frequent genetic alteration in bladder cancer identified to date, suggesting the presence of key gene(s) for this pathology. In this study, we examined 44 bladder tumors and 21 normal bladder samples for LOH on both arms of chromosome 9. Sixteen microsatellite markers, 12 on the short arm (encompassing 9p21-22) and 4 on the long arm (encompassing 9q33-34), were chosen for their highly frequent alterations in bladder cancer. LOH for at least one marker was identified in 42 tumor samples (95.5%), and 14 tumors (32%) displayed LOH for all informative tested markers. Detailed analysis showed that 2 markers on chromosome 9p (D9S157 and D9S156) had the highest frequencies of allelic loss (about 70%), independent of tumor grade and stage. The same study was performed on the 21 normal bladder mucosa samples: 50% of informative cases presented a single specific LOH at the D9S156 locus. Normal samples showing LOH at this locus were therefore screened with 3 novel microsatellite markers in the 810-kb region incorporating D9S156. Using this marker, we found no further heterozygous loss in this region. This result allows different interpretations of the D9S156 loss in normal bladder mucosa, and suggests that D9S156 may be more an indicator of bladder epithelium impairment than a tumor-initiation marker. Similarly, this unexpected result calls in question the interpretation of LOH studies.

Aged↗
PubMed1998

[Use of the Valtrac ring for digestive anastomoses in urology: apropos of 16 cases].

The Valtrac ring is a biofragmentable ring used for gastrointestinal anastomoses. Over a two-year period, 15 anastomoses in 16 patients (mean age: 60 years) were performed with the Valtrac ring: 10 ileal, 4 ileocolonic, and 1 jejunojejunal anastomoses. One anastomosis could not be performed because of an excessively narrow ileal lumen. The mean stay in the intensive care unit was 3 days: gastric aspiration was maintained for an average of 1 week, as return of gastrointestinal motility was long, with first flatus on the 6th day and the first stools on the 7th day. Complications consisted of 2 cases of gastrointestinal fistula (11th and 13th days) one of which was fatal, evisceration on the 7th day, a transient partial bowel obstruction and one bowel obstruction treated medically on the 27th day, due to pancreatitis. Our results are not identical to those reported in the literature. It is often difficult to insert the current form of the Valtrac ring into a healthy ileum, as the smallest ring is often too large. In contrast with gastrointestinal surgery, the anastomoses performed in urology involve a non-thickened, non-distended small intestine.

Adult↗
PubMed1998

[Treatment using percutaneous arterial embolization of post-traumatic priapism in children].

High flow rate priapism was diagnosed in a 14-year-old adolescent 5 days after a fall onto the perineum. Highly selective embolization of the 2 internal pudendal arteries was performed with gelatin (SPONGEL). Rapid resolution of the priapism as well as return of normal erection were observed within 48 hours. Doppler ultrasound revealed a high flow rate and identified the side of the traumatized artery. Endovascular embolization allows effective treatment of traumatic arteriocavernous fistula.

Accidental Falls↗
PubMed1997

Glucocorticoids do not regulate the expression of proteolytic genes in skeletal muscle from Cushing's syndrome patients.

Glucocorticoids signal enhanced proteolysis in various instances of muscle atrophy and increased gene expression of components of the lysosomal, Ca(2+)-dependent, and/or ubiquitin-proteasome proteolytic pathways in both rat skeletal muscle and myotubes. Cushing's syndrome is characterized by chronic excessive glucocorticoid production, which results in muscle wasting. We report here no change in messenger RNA levels for cathepsin D (a lysosomal proteinase), m-calpain (a Ca(2+)-activated proteinase), ubiquitin, 14-kDa ubiquitin-activating enzyme E2, and 20S proteasome subunits (i.e. critical components of the ubiquitin-proteasome proteolytic process) in skeletal muscle from such patients. Thus, in striking contrast with animal studies, glucocorticoids did not regulate the expression of muscle proteolytic genes in Cushing's syndrome. In humans, messenger RNA levels, for at least ubiquitin and proteasome subunits, are elevated in acute situations of muscle wasting, such as head trauma or sepsis. Because Cushing's syndrome is a chronic catabolic condition, we suggest that the lack of regulation of proteolytic genes in such patients may represent an adaptive regulatory mechanisms, preventing sustained increased protein breakdown and avoiding rapid muscle wasting.

Adult↗
PubMed1996

[Parietal calcifications of the kidney pelvis in Corynebacterium urealyticum urinary infection].

Linear renal pelvis calcifications in a native kidney due to Corynebacterium urealyticum are described. These micro-organisms have an opportunistic behaviour and can be responsible for nosocomial urinary tract infection. Alkaline incrusted cystitis with linear vesical calcifications are considered as the most typical pattern. Renal pelvis may also be concerned, with parietal calcifications.

Calcinosis↗
PubMed1996

[Epithelioma of the penis treated with surgery. Study Group on Urogenital Tumors of the National Federation of the Centers for Cancer Control].

OBJECTIVES: To evaluate the efficacy and morbidity of surgical treatment of carcinoma of the penis. This series of patients was derived from a retrospective multicentre study (1959-1989), initially concerning 506 patients, all treatments combined. METHODS: One hundred and sixty-eight patients treated by surgery or surgery followed by external radiotherapy between 1959 to 1989 were included. The mean follow-up is 14.4 years and the mean participation is 4.7 years. Total or partial amputation was performed as first-line treatment in 89 patients (53%) and as second-line treatment in 11 patients (7%). Thirty-two patients received external radiotherapy as a complement to surgery. Inguinal lymph node dissection was performed as first-line treatment in 68 patients (41%) and secondarily in 19 patients (11%). Postoperative inguinal radiotherapy was performed in 52 patients. Monofactorial statistical analysis of prognostic factors is proposed. RESULTS: The 5-year local control rate was 84%; it was independent of the stage of the tumour; the survival of the patients dying from any cause was 53%, the progression-free survival was 69% and the survival of patients dying from cancer of the penis was 75%. The vital prognosis is statistically significant related to the lymph node status. No significant relationship was observed between lymph node status and tumour stage. 61 complications involving the penis were observed in 40 patients (24%). Thirty-seven patients developed complications secondary to the lymph node dissection (24 cases of oedema of the lower limbs and 13 cases of inguinal sclerosis). CONCLUSION: Surgical treatment ensured a local control globally comparable to that obtained with brachytherapy, but unlike this technique, the local control is independent of the stage. Brachytherapy should not always be performed in favour of mutilation for advanced tumours because the iatrogenic effects of brachytherapy are increased in these cases. An approach to the treatment of lymph nodes is proposed based on the authors' experience and the data of the literature.

Adult↗
PubMed1995

[Ultrasonography and tomodensitometry staging of kidney tumors: anatomo-radiologic correlations in 46 patients].

OBJECTIVE: To comparatively evaluate CT scan and MRI in the preoperative staging of renal tumours. METHODS: 46 patients with a solid renal tumour were investigated preoperatively by CT scan (n = 43) and MRI (n = 46), the results of which were compared with pathological data. RESULTS: MRI assessed capsular effraction with a sensitivity of 95.6% and a specificity of 52.1%, versus 95.2 and 40%, respectively, for CT scan. Three cases of perirenal extension were detected by MRI. The sensitivity of MRI was higher than that of CT scan for the demonstration of adenopathy (71.4% versus 57.1%) with specificities of 92.3 and 88.8%, respectively. Fourteen cases were associated with tumour extension into the proximal renal vein, which extended into the distal segment of this vein in 12 cases, into the inferior vena cava in 6 cases and as far as the right atrium in 2 cases. The performance of MRI was always better than that of CT scan in relation to venous segments of surgical interest (respective sensitivities of 70% and 83.33% in the distal renal vein and 66.6% and 83.33% in the inferior vena cava: and respective specificities of 84.8% and 97% in the distal renal vein and 91.8% and 97.5% in the inferior vena cava), provided the results of T1-weighted spin echo sequences and FLASH gradient echo sequences were assessed conjointly. CONCLUSION: These results lead us to now prefer MRI to CT scan for the preoperative staging of renal cancer, in the presence of a contraindication to iodinated contrast agent injection, very large tumours, and whenever venous extension is suspected on ultrasonography.

Adult↗