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Biomedical subjects

J P Capron

Publications and source records attributed to J P Capron.

At least 91 records · Page 5Linked to original sources
PubMed1988

Nadolol for prophylaxis of gastrointestinal bleeding in patients with cirrhosis. A randomized trial.

This controlled trial was designed to evaluate the prophylactic effect of nadolol on gastrointestinal bleeding in cirrhotic patients with large oesophageal varices who had never bled. Nadolol or placebo was given randomly to two groups of 53 patients. The percentage of patients free of gastrointestinal bleeding 1 year after inclusion in the study was 83 +/- 6% (mean +/- S.D.) in the nadolol group and 80 +/- 6% in the placebo group. In the nadolol and placebo groups, 40 and 47 patients, respectively, were compliant, i.e., took nadolol or placebo continuously. The percentage of patients who were free of bleeding 1 year after inclusion was 97 +/- 3% in the subgroup of compliant nadolol patients. This percentage was significantly higher than that of patients who were free of bleeding in the placebo group (P less than 0.03) as well as in the subgroup of compliant placebo patients (77 +/- 6%; P less than 0.02). We concluded that, although there was no overall significant effect of nadolol on the risk of bleeding in cirrhotic patients in good condition with large oesophageal varices, this study suggests that nadolol reduced the risk of bleeding in compliant patients.

Clinical Trials as Topic↗
PubMed1988

Thyroid carcinoma in two sisters with familial polyposis of the colon. Case reports and review of the literature.

Multicentric thyroid papillary carcinomas were present in two sisters with familial polyposis of the colon; in one the tumor was found at age 29 and in the other at 26 years of age, respectively 13 and 5 years after colectomy. This association is not fortuitous and should lead to regular examination of thyroid gland in patients with familial polyposis or in Gardner's syndrome patients. It might even be wise to search for adenomas of the colon in young patients with thyroid carcinoma.

Adenomatous Polyposis Coli↗
PubMed1988

Epidermolysis bullosa acquisita and Crohn's disease. A case report with immunological and electron microscopic studies.

A review of the literature shows that the association of epidermolysis bullosa acquisita and Crohn's disease is rare. A 27-year-old man developed cutaneous blisters on the trauma-prone areas that were consistent with the diagnosis of epidermolysis bullosa acquisita. Immunological and electron-microscopic studies of the skin showed intense IgG deposits located beneath the basal lamina. Three years later, Crohn's colitis was diagnosed. Prednisolone and sulfasalazine treatment resulted in an improvement of the bowel disease but without appreciable effect on the skin lesions.

Adult↗
PubMed1988

Hepatic subcapsular biloma. An unusual complication of endoscopic retrograde cholangiopancreatography.

Development of an intraabdominal bile collection (biloma) usually occurs secondary to traumatic or iatrogenic injury including abdominal surgery, percutaneous catheter drainage, and transhepatic cholangiogram. We present a case of hepatic subcapsular biloma following endoscopic retrograde cholangiography and identified by ultrasound and computed tomodensitometry examinations. A percutaneous drainage procedure allowed a subsequent endoscopic retrograde cholangiopancreatography to be performed that documented the location and extent of the bile leak and led to resolution of the biloma.

Aged↗
PubMed1988

[Histomorphometric study of the gastric mucosa in portal hypertension].

Histologic features of the gastric (antral and fundic) mucosa in 14 patients with portal hypertension due to alcoholic cirrhosis and a mosaic pattern of the fundic mucosa at endoscopic examination have been compared with those of the gastric mucosa in 14 control subjects. We attempted to correlate endoscopic and histologic aspects using a semiquantitative morphometric study in which the height of the mucosa, the number per mm2 and the diameter of vascular sections of the interglandular chorion, and the number per mm2 of large (greater than or equal to 20 micron) vascular sections of the superficial chorion were measured. For all parameters, the mean values were higher in cirrhotic patients than in controls, but significant differences were found only in the antral mucosa (height of the mucosa and number of large vascular sections in the superficial chorion). These results confirm the frequency and the importance of vascular abnormalities of the gastric mucosa in patients with portal hypertension, but do not explain, at least with the methodology used, the mosaic pattern of the fundic mucosa disclosed in most cirrhotic patients.

Biopsy↗
PubMed1988

[Acute pancreatitis caused by papillary adenoma of the distal common bile duct. Treatment by endoscopic excision].

We report the case of a 66 year-old man who developed acute necrotizing pancreatitis. The usual etiologies of acute pancreatitis were easily excluded. Endoscopic retrograde cholangiopancreatography demonstrated a 10 mm diameter filling defect in the distal common bile duct. After endoscopic sphincterotomy, a polypoid tumour which appeared to arise from the common bile duct was delivered through the wound. Diathermic resection of the tumor was performed. Microscopic examination disclosed papillary adenoma, without histologic signs of malignancy. Follow-up was favorable.

Acute Disease↗
PubMed1987

Pseudomonas aeruginosa liver abscesses following endoscopic retrograde cholangiography. Report of a case without biliary tract disease.

We report a case of Pseudomonas aeruginosa liver abscesses following endoscopic retrograde cholangiopancreatography (ERCP) in a patient without evidence of biliary tract disease and of any known cause of hepatic infection. Computer tomography (CT) scan was the best method of diagnosis, allowing, through guided percutaneous puncture of the abscesses, isolation of the organism, which was sensitive to carbenicillin. One month of antibiotherapy with repeated aspirations of the largest abscesses was successful. This report suggests that ERCP may induce cholangitic sepsis by inoculating pathogens in the biliary tree even in the absence of extrahepatic obstruction.

Adult↗
PubMed1987

[Hepatocellular carcinoma invading the right atrium: clinical, echographic and angiographic study].

The authors report the case of a 54 year old woman suffering from hepatocellular carcinoma with tumor growth into right hepatic vein, inferior vena cava and right atrium. On cardiac examination, a pansystolic bruit and a diastolic rumble were audible at the tricuspid focus. Diagnosis was confirmed by inferior vena cavography and two-dimensional echocardiography, which demonstrated a large mobile mass in the right atrium moving to and fro through the tricuspid valve. This case report emphasizes the value of routine cardiac examination during the course of hepatocellular carcinoma.

Carcinoma, Hepatocellular↗
PubMed1987

[Immunoblastic lymphoma of the ileocecal region in chronic lymphoid leukemia. Richter's syndrome localized in the intestine and disclosed by ascites].

The authors report the case of a patient with chronic lymphocytic leukemia well controlled during five years, and then complicated with immunoblastic lymphoma of the ileo-caecal area. The tumor was revealed by a protein-rich peritoneal effusion containing numerous large undifferentiated lymphoid cells. Only five cases of Richter's syndrome, apparently localized to the digestive tract, have been published to date.

Ascites↗
PubMed1987

[Gardner's syndrome and epidermoid cyst of the thymus].

The hitherto undescribed association of Gardner's syndrome (familial adenomatous polyposis coli, abdominal fibromas, osteoma, dental abnormality, cystic fundic gland polyposis) with a thymic epidermoid cyst in a 38 year old woman is reported. Thymic cyst was discovered on a routine chest roentgenogram, and diagnosis, suspected by CT findings, was established by histological examination of surgical material. The authors suggest that this association is not fortuitous.

Adult↗
PubMed1987

[Hepatic brucelloma (pseudotumoral brucellar caseous necrosis of the liver). Study of a case and review of the literature].

We report the case of a 43 year-old Portuguese woman, hospitalized for long-standing fever, fatigue and weight-loss. Biologic investigation demonstrated anicteric cholestasis. Abdominal plain film showed a single hepatic calcification; computerized tomography and ultrasonography of the liver led to the discovery of a large mass, centered by the calcification. C. T.-guided biopsy showed caseiform necrosis, surrounded by histiocytic and lymphocytic cells. Brucella agglutination tests were negative at the beginning of the illness but became positive secondarily. The germ was not isolated from the hepatic fragment. The melitine intradermo-reaction was positive. Outcome was rapidly favorable with antibiotic treatment. Analysis of the 14 previously published cases showed that the most constant features were the hepatic calcifications and the epidemiologic context.

Adult↗