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Biomedical subjects

J P Castel

Publications and source records attributed to J P Castel.

At least 19 recordsLinked to original sources
PubMed2003

[Origin and consequences of the hypodensity surrounding spontaneous intracerebral hemorrhage in the acute phase].

In the acute phase, spontaneous intracerebral hemorrhage is surrounded by hypodensity, the origin of which is controversial. Its clinical consequences are still under evaluation. Surrounding cerebral ischemia was suggested as its main etiology, but no experimental or clinical data currently supports this etiology. The hypodensity reflects the presence of cytotoxic and vasogenic edema secondary to prolonged contact between hemorrhage and adjacent brain tissue. This would mainly be due to local release of activated thrombin. However, other metabolites released from blood degradation products would also be involved. This edematous process is unique due to its early occurrence (as early as 2 hours), early maximum peak (24 hours), and regression over the next few days. In humans, no definitive proof exists that this edematous process of variable intensity is pathological. No specific treatment is currently available.

Acute Disease↗
PubMed2001

Dysautonomia syndrome in the acute recovery phase after traumatic brain injury: relief with intrathecal Baclofen therapy.

In the initial phase of severe head injury, dysautonomic abnormalities are frequent. Within the framework of a prospective study, evaluating the efficacy of continuous intrathecal Baclofen therapy (CIBT) on hypertonia during the initial recovery phase of severe head injury, the authors report on the preliminary results of this treatment on paroxysmal dysautonomia about four patients. Continuous intrathecal Baclofen infusion was first delivered, for a test period, continuously for 6 days. If a relapse of dysautonomia occurred at the end of the test period, an implantation of a continuous intrathecal infusion pump delivering Baclofen was performed. Results were assessed with four continuous variables; duration (days), dose of Baclofen per day (microg/d), number of dysautonomic paroxysmal episodes per day, and initial recovery evaluated by a scale of the first initial stages of head injury coma recovery. For three patients: (1) the number of dysautonomic paroxysmal episodes per day and the doses of Baclofen during the follow-up period were correlated (p = 0.02, p < 0.001, p = 0.008, respectively, distribution-free test of Spearman), (2) during the test period and the relapse after the test period, the number of paroxysmal episodes and the Baclofen dose are correlated to p < 0.05, p = 0.03, p = 0.04, respectively (distribution-free test of Spearman). The second statistical test was used to prove that Baclofen doses and number of paroxysmal dysautonomic episodes are correlated independently of the duration of follow-up. The fourth patient improved with CIBT without any recurrence at the end of the treatment test period. For the four patients, recovery score increased during the overall follow-up. In the authors' experience CIBT is very efficient to control paroxysmal dysautonomia during the initial recovery phase in severe head injury, and seems to facilitate recovery.

Acute Disease↗
PubMed2001

[Postoperative morbidity and mortality after microsurgical exclusion of cerebral arteriovenous malformations. Current data and analysis of recent literature].

BACKGROUND AND PURPOSE: Microsurgical exclusion of a cerebral arteriovenous malformation (AVM) can compare favorably with radiosurgery. We sought to assess its rate of morbidity-mortality as it is presently reported in the literature, and to discuss some of its current and worthwhile indications. METHODS: Through Medline and additional searches by hand, we retrieved studies reporting the clinical and angiographic results after microsurgical excision of an AVM published between january 1990 and december 2000. RESULTS: a) Postoperative mortality was 3.3% (68/2 452 patients from 25 studies). Permanent postoperative morbidity was 8.6%. Morbidity was never absent varying from 1.5% to 18,7%. The morbidity-mortality rate increased with an increasing Spetzler-Martin's grade, and was related to the location of the AVM. A 4.6% morbidity (from 1.5% to 9.7%) and a zero mortality were reported after microsurgical removal of small lesions of less than 3 cm in diameter. b) Postoperative angiography confirmed a total excision of the AVM in 97% of the cases (1 050/1 076 patients over 11 series), varying from 91% to 100%. c) Permanent morbidity related to pre-surgical embolization varied from 4% to 8.9%. Results from multiple or combined treatment including microsurgery could not be summed up. CONCLUSIONS: A complete and definitive microsurgical excision of an AVM can be achieved with a high success rate and a low morbidity-mortality rate, according to sound indications and to the neurosurgeon's personal experience. The choice for a best treatment of an AVM is no longer limited to microsurgery; it is a team decision where the neurosurgeon plays a determining role.

Adult↗
PubMed1998

[Chronic bilateral subdural hematomas].

BACKGROUND AND PURPOSE: Are chronic bilateral subdural hematomas different from unilateral forms in terms of delay of diagnosis, clinical presentation and post-operative recovery or recurrence? METHODS: Etiological, clinical, and radiological aspects and management outcome of bilateral chronic subdural hematomas consecutively managed from 1990 to 1995 were retrospectively analyzed and compared with unilateral forms managed in the same neurosurgical unit during the same period of time. RESULTS: There were 236 cases. Bilateral subdural hematomas occurred in 41 patients (17.4%). A good outcome was obtained in 97.5% of the cases and morbidity was 14.6%. The differences significantly observed between unilateral and bilateral subdural hematomas were duration of the prediagnostic period, pneumatoceles and recurrence rates (12%). Recurrences were all observed during the first postoperative month and treated with the same initial standardized procedure. The rate of infection or epileptic seizures was low. CONCLUSIONS: There are few limited differences between uni- and bilateral chronic subdural hematomas. In the latter, a possible correlation between the duration of prediagnostic period and an increased rate of recurrence could be explained by poorer cerebral reexpansion. The overall prognosis of bilateral hematomas is comparable with that observed in unilateral forms. A simple and routinely used burr hole procedure either under local or general anesthesia associated with closed drainage is a safe surgical procedure for either bilateral or unilateral forms and can be performed in all the cases including recurrences. Systematic antiepileptic drugs or antibiotherapy are unnecessary in the medical management of chronic subdural hematomas. One late delayed postoperative clinical control seems to be sufficient.

Aged↗
PubMed1996

Amyloid angiopathy-related cerebellar hemorrhage.

BACKGROUND: The posterior fossa localization of amyloid angiopathy-related hemorrhage is very unusual. Less than 10 cases have been previously reported. Surgical management of amyloid angiopathy-related hemorrhage is the subject of controversy. RESULTS: Typical aspects of amyloid angiopathy were found within the surgically removed biopsies of 71-year-old nonhypertensive, nondemented woman suffering cerebellar hemorrhage. CONCLUSIONS: Amyloid angiopathy-related hemorrhage could occur in the cerebellum, and diagnosis might be suspected when no past history of mental deterioration and/or arterial hypertension are present and when angiography rules out vascular malformation. Surgical management seems to have the same restricted indications as in other brain areas.

Aged↗
PubMed1996

[Severe hyperthermia caused by sudden withdrawal of continuous intrathecal administration of baclofen].

Baclofen is used for the treatment of post-traumatic spasticity. It carries a risk of overdose as well as of an acute withdrawal syndrome. We report two cases of severe hypertonia and hyperthermia (> 42 degrees C), occurring after accidental discontinuation of intrathecal infusion of baclofen. Both hypertonia and hyperthermia ceased when administration of baclofen was resumed. In parallel, the patients developed transient life-threatening alterations of hepatic (cytolysis), haematologic (coagulopathy) and cardiorespiratory functions for some days. It is concluded that the occurrence of such a withdrawal syndrome should be prevented, especially in patients with chronic intrathecal administration and first symptoms should be recognized without delay. Relationships with other malignant hyperthermias are discussed.

Adult↗
PubMed1995

[Paraganglioma of the cauda equina. Clinical aspects and MRI. Apropos of a case].

The clinical and imaging features of a paraganglioma of the cauda equina are presented. A peridural anesthesia revealed the cauda equina compression syndrome in a 68 years old man who presented first with a urinary retention. Total surgical excision of a long round-shaped encapsulated tumor was uneventful. Macroscopically this lesion filled up the spinal canal and resembled to a meningioma. It was firmly attached to the filum terminale. Adjacent large arterialized vessels visible on MRI were spared. Although the diagnosis could be evoked pre-operatively on some suggestive patterns on the MRI, the pathological findings finally confirmed the diagnosis of paraganglioma. Along with the evidence of specific light microscopic features, the use of an immunocytochemical demonstration of synaptophysine in these tumors allows a confident diagnosis to be made.

Aged↗
PubMed1994

[Neurosurgical treatment of intracranial aneurysms].

This text summarizes the course organized for residents and trainees by the Société de Neurochirurgie de Langue Française. It was presented by the authors during the annual winter meeting held in Paris in December 1992. The aim of this course was to discuss all the technical points needed to achieve safely a microsurgical clipping of an intracranial aneurysm of the anterior circulation. Although many of these technical points discussed can apply to any kind of intracranial aneurysm, the very specific difficulties of the treatment of giant aneurysms or posterior circulation aneurysms were not mentioned. The usual pterional approach is described. The need of having a slack brain to perform easily the dissection of the aneurysm is stressed. Standards of hemodynamic control during surgery are described either with the use of a total or a proximal temporary clipping under the electrophysiologic control of the somesthetic evoked potential. Prevention of peroperative cerebral ischemia and brain protection are discussed. Dissection of the aneurysm is presented step by step until clipping. Different ways of clipping are discussed after a short description of the characteristics and composition of various available clips. How to deal with a premature intra-operative rupture of the aneurysm is also discussed. The last chapter describes step by step the approach and clipping of the four most frequent aneurysm locations i.e. at the posterior face of the intracranial internal carotid artery, the intracranial carotid bifurcation, the middle cerebral artery, and the anterior communicating artery.

Aneurysm, Ruptured↗
PubMed1991

Death and functional outcome after spontaneous intracerebral hemorrhage. A prospective study of 166 cases using multivariate analysis.

Using death and functional status as end points, we prospectively analyzed the outcome 6 months after spontaneous intracerebral hemorrhage in 166 patients admitted to an acute-care stroke unit on the first day of their stroke. Seventy-one patients (43%) died, 69 (42%) had a satisfactory outcome, and 26 (16%) had a poor functional outcome. Early (30-day) survival was correlated with morphologic parameters on the initial computed tomogram (hemorrhage size, midline shift, and intraventricular spread of the hemorrhage), while later (6-month) survival was correlated with age. Using logistic regression, we found five independent predictors of satisfactory outcome at 6 months: age, hemorrhage size, intraventricular spread of the hemorrhage, limb paresis, and communication disorders. Of these, age was the most important predictor by far.

Adult↗
PubMed1991

[Continuous CSF aspiration. An alternative in the management of acute hydrocephalus].

As proposed by Marmarou in 1976, in case of acute hydrocephalus high intracranial pressure (I.C.P.) can be controlled by withdrawing the ventricular cerebrospinal fluid (C.S.F.) at a constant rate equal to the rate of C.S.F. formation. We experienced this procedure since 1989 in 17 patients presenting with acute hydrocephalus consecutive to aneurysmal subarachnoid hemorrhage (11 cases) or infratentorial mass (6 cases). A ventricular catheter was connected to an electrical syringe of which the motor driving direction has been inverted. Using an outflow rate ranging from 0.15 to 0.20 ml/mn, i.e. lower than the physiological C.S.F. rate formation, this controlled continuous mechanical ventricular C.S.F. drainage has serious advantages compared to a traditional external ventricular C.S.F. drainage. These advantages are mainly the better control of intracranial pressure (fiability of I.C.P. monitoring, lowered risk of hyperdrainage), more comfort for the patient and the nursing staff and lower cost.

Acute Disease↗
PubMed1990

The epidemiology of head trauma in Aquitaine (France), 1986: a community-based study of hospital admissions and deaths.

This paper reports the findings of a study of head trauma conducted over a one-year period within a defined region with a population of 2.7 million (Aquitaine, France). It includes cases resulting in death prior to hospitalization or requiring hospitalization. During the one-year period, 391 deaths and 8549 hospital admissions due to head trauma occurred, yielding an annual estimate of 8940 head-injured people. The immediate case-fatality rate was 4.4%. Among non-fatal cases, 80% were mild, 11% moderate and 9% severe. The overall annual incidence was 281/100,000 in both sexes (384 and 185/100,000 in males and females respectively). The annual death rate was 22/100,000 (33 and 12, respectively). Patterns of incidence by age and sex were in general agreement with earlier studies. The main causes of head trauma were traffic accidents (60%) and falls (33%). One-third of hospitalized patients had no injury other than the head trauma. The most frequently associated injuries were those involving extremities, whereas the most severe were those involving the abdomen. The Injury Severity Score (ISS) ranged from 4 to 66, with a mean of 9 and a median of 5. At the eighth day following injury, 25% of hospital-treated patients were still hospitalized and 2% had died. The outcome correlated well with the ISS.

Accidental Falls↗