About a case of necrolytic migratory erythema erythema revealing a malignant pancreatic glucagonoma, the authors compare the results of their study with the 25 cases published in the world.

Adult↗

PubMedDate not supplied

Human peripheral Nullymphocytes: ultrastructural aspects of the "K" cell effect against a melanoma target cell.

A null cell fraction was isolated from human peripheral blood by Ficoll density gradient centrifugation followed by removal of mononuclear phagocytes, passage through Ig-antiIg columns and sedimentation of E-rosette forming T cells. In contrast to the T cell fraction in the Null cell population exhibited cytotoxic activity against antibody-sensitized human melanoma target cells (ADCC reaction). This activity could be attributed to a low affinity Fc-receptor bearing cells present in the Null cell preparation. At the ultrastructural level in 2 h ADCC reaction most tumor cells were surrounded by up to 10 lymphoid cells which showed narrow junctions with parallel plasma membranes and local evaginations of lymphoid cells into recessus of the target melanoma cells. The mononuclear cell type found in close contact with the antibody-sensitized target cells had the following morphological criteria: 8 to 10 mu diameter, irregular nucleus, discrete rough endoplasmic reticulum, isolated ribosomes, cytoplasmic organelles concentrated under a ruffling membrane in the contact area with the tumor cell.

Antibody-Dependent Cell Cytotoxicity↗

PubMedDate not supplied

[IgG subclasses in malignant melanoma].

The 397 sera from 185 melanoma patients have been studied and classified in three groups according to the stage of disease. Our findings revealed an alteration of the level of IgG4 subclass which is related to the dissemination of disease. The percentage of abnormalities (either increased or decreased levels of IgG4) was more frequent in stage II and III (55% and 53% respectively) than in stage I (19%), The higher frequencies of high titers of IgG4 were essentially detected in advanced disease. The biological significance of the increase of IgG4 in melanoma remains obscure. It may be related to the development of facilitating antibodies of IgG4 subclass.

Humans↗

PubMedDate not supplied

[IgG levels in the sera of melanoma patients (author's transl)].

397 sera from 185 melanoma patients have been tested. We classified our subjects into three groups, according to the stage of disease. An alteration of the level of IgG 4 sub-class was found and related to the extension of the disease. The percentage of abnormalities was more frequent in stage II and III (55 p. 100 and 53 p. 100) than in stage I (19 p. 100). High titers of IgG 4 subclass were essentially detected in advanced disease. The biological significance is discussed.

Humans↗

PubMedDate not supplied

[IgG levels in the sera of melanoma patients (author's transl)].

397 sera from 185 melanoma patients have been tested. We classified our subjects into three groups, according to the stage of disease. An alteration of the level of IgG4 subclass was found and related to the extension of the disease. The percentage of abnormalities was more frequent in stage II and III (55 p. 100 and 53 p. 100) than in stage I (19 p. 100). High titers of IgG 4 subclass were essentially detected in advanced disease. The biological significance is discussed.

Humans↗