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Biomedical subjects

J P Chodkiewicz

Publications and source records attributed to J P Chodkiewicz.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Cerebrovascular accidents and oral contraceptives (reflections a propos of 36 observations)].

Thirty-six cases of cerebro-vascular accidents in young women using oral contraceptives have been studied and a survey of the literature devoted to the subject gives an opportunity to discuss a few problems related with these accidents. They occur with no evident relationship with the type of drug used, and the duration of treatment; in 66 p. 100 of the cases these patients have a definite and sometimes severe pathological history prior to the neurological accident. The cerebro-vascular accidents are of the ischemic type in more than 80 p. 100 of the cases. Angiographic studies demonstrate various types of lesion: stenosis or thrombosis of the arteries; in almost all of the cases the internal carotid artery or the sylvian artery or both of them are concerned; the angiogram appeared normal in 8 cases.

Adult↗
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Stereotactic endocavitary treatment of cysts and pseudocysts of glioma. Preliminary report.

The present study reports the results of the stereotactic treatment via endocavitary irradiation (Talaraich's method) of 50 gliomatous cysts (volume: 5-242 cm3; av.: 73 cm3) in 45 patients (M: 24; F: 21; age 3.5-57 yrs; av.: 22 yrs) in the period January 1973-January 1987. Twenty-four patients (27 cysts) were affected by a grade I glioma, 10 patients (12 cysts) by a grade II and 11 patients (11 cysts) by a grade III or IV glioma. The first step in the treatment was a neuroradiological stereotactic stereoscopical survey (tele-angiography, ventriculography, cystography) with serial biopsies and a cystic impermeability test (injection of 0.3-1 mCi of Re 186). One week later one therapeutic dose, ranging between 5 and 85 mCi of a beta-emitting colloidal radioisotope (Re 186, Au 198, Y 90), was stereotactically injected into the cyst. The stereotactic treatment was not followed by severe side effects. In high grade gliomas (grade III and IV) the benefit of the possible shrinkage and/or disappearance of the cyst was vanished by the solid tumor progression. In low grade gliomas (grade I and II) more than 50% of the cysts disappeared and 25% of them shrinked up to one third of the starting volume (follow-up: 5-168 mo.; av.: 54 mo.). At present almost only Re 186 is employed using a cyst wall dose of 400-500 Gys. The low surgical invasiveness, the absence of severe side effects and good therapeutical results induce us to propose this as a first choice treatment in inoperable low grade gliomatous expanding cysts.

Adolescent↗
PubMedDate not supplied

Long term results of stereotactic endocavitary beta irradiation of craniopharyngioma cysts.

This study concerns 33 pts (age: 3-69 yrs; m: 22) with cystic craniopharyngiomas (36 cysts) treated with stereotactic beta endocavitary irradiation (TRT). Nine patients died (3 days to 36 months after TRT) and one was lost. In 23 the follow-up varied from 12 to 126 months (m: 45 months). The disappearance of 13 cysts was appreciated 5 to 24 months after TRT: no recurrence was observed after 22-126 months (m: 61). A greater than 70% reduction of the cyst volume occurred 3-36 months after TRT and persisted at 12-71 months (m: 35 m). In one patient, the cyst volume increased. Visual acuity improved in more than 50% of survivors, while endocrine disturbances did not change and memory troubles disappeared.

Adolescent↗