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Biomedical subjects

J P Daniel

Publications and source records attributed to J P Daniel.

4 recordsLinked to original sources
PubMed1992

[Peroperative evaluation of pulmonary vascular resistance by cavo-pulmonary bypass. Value of atrio- and cavo-pulmonary diversions].

Immediate and long-term results of the Fontan procedure depend on the value of the pulmonary vascular resistance. This parameter cannot always be quantified accurately during preoperative evaluation. Cavo-pulmonary bypass using an extra corporeal circulation allowed simulation a Fontan procedure in 5 patients, and prediction of the pressure changes in the pulmonary artery and the systemic atrium according to the pulmonary to systemic resistances ratio. This technique could be valuable in border line cases for deciding on the optimal therapeutic solution.

Anastomosis, Surgical↗
PubMed1987

Generation of protective immune sera by Crotalus durissus terrificus venom detoxified by controlled iodination.

1. Whole soluble venom from the snake Crotalus durissus terrificus was detoxified by controlled iodination. Doses equivalent to 100 LD50 of the native venom were administered to mice, without signs of intoxication. 2. The non-toxic iodinated derivatives were able to stimulate antibodies in rabbits and horses within a short period (6 months) of immunization. Horse antisera attained titers of 0.5 to 0.9 mg/ml for protection against native venom. 3. Horse antisera obtained in horses from native and iodinated venom were run against both native and iodinated venoms, as antigens, in gel immunodiffusion. The precipitation lines showed total identity of the two types of sera.

Animals↗
PubMed1986

Detoxification of the T2 fraction from a scorpion (Tityus serrulatus, Lutz and Mello) venom by iodination and some immunogenic properties of the derivatives.

The iodination of the T2 fraction abolished its lethal capacity, and doses up to 30 times the LD50 were injected i.p. in mice without noticeable toxic effects. The modified fraction retained its immunological properties. Antibodies generated against the iodinated T2 fraction were also reactive toward the native T2 fraction, T1 fraction and the whole soluble venom.

Animals↗