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J P Grilliat

Publications and source records attributed to J P Grilliat.

At least 19 recordsLinked to original sources
PubMed1976

[Does allergy of the digestive tract exist? (author's transl)].

Factors which set up an allergy of the digestive tract are alimentary antigens, fungal or bacterial antigens, drugs, among other things. The allergy is favored by achlorhydria, lack of pancreatic or duodenal enzymes or inflammations of the gastro-intestinal mucosa. The origin of a digestive allergy quite decisively depends on the A immunoglobulins. They can combine with high molecular weight antigens and so inhibit the transit of the active antigen. In the diagnosis, the authors have found a test particularly useful in which a few drops of antigen solution are administered sublingually. Therapy includes restoration of disturbed digestive functions, an individually planned diet and the avoidance of alcohol and strong spices.

Adult↗
PubMed1976

[Specific and non-specific histamine liberation].

Histamine-liberation occurs mainly from the mast cells and basophils, the sitr of synthesis of histamine, and other intermediary substances such as serotonin, S.T.S.A. The possible causes for this histamine-liberation are numerous and varied. Histamine-liberation of immunological order only represents a particular case in this chapter as a whole. The study quite specifically deals with histamine-legeration provoked by the direct pharmacodynamic action of drug substances, in particular those which are used in anaesthesiology. These substances are numerous and act according to two essential mechanisms: action by diffusion in the region of the histamine carrying cell (the case of substances of low molecular weight), enzymatic action on the cell membrane (the case of substances with high molecular weight). From the standpoint of clinical consequences, discrimination between specific and non-specific histamine-liberation is therefore risky. In practice, in the face of a symptomatology of histamine shock, it is necessary to bear in mind what is known of the pharmacological action of the substances used, and on the other hand not to neglect the resources of the history, and to employ the laboratory tests capable of providing arguments for or against anaphylaxis.

Basophils↗
PubMed1975

Clinical trial of Ro 6-0787, a monovalent specific hapten inhibitor of penicillin allergy.

A second clinical trial of the compound Ro 6-0787, which is a specific monovalent penicilloyl hapten inhibitor of allergic reactions to penicillin has been conducted by investigators from 9 different European groups in 90 patients allergic to penicillin. The effect of a combined Ro 6-0787-penicillin therapy was considered as clinically successful in the large majority of cases, since treatment with penicillin could be pursued or resumed without allergic manifestation in 42 from 46 cases (91 percent). The effect of Ro 6-0787 alone on acute allergic manifestations after interruption of penicillin therapy was more difficult to evaluate but was nevertheless considered satisfactory in 17 from 26 patients (65 percent). A depression of skin hypersensitivity to PPL and/or penicillin and penicillin derivatives sometimes persisting for weeks and months was obvious in numerous allergic patients submitted to combined Ro 6-0787-penicillin treatment. A depressing effect on antipenicillin antibody titers detected by passive hemaglutination was also manifest in some patients. Failure to suppress allergic manifestations was reported in 11 cases, among which some may have been due to insufficient dosage of inhibiting hapten. The overall tolerance of Ro 6-0787 in allergic patients has been very good. Nevertheless, the major obstacle to a wider general use of Ro 6-0787 at the present time appears to be the occurrence of positive skin reactions to that compound in approximately 5 percent of patients allergic to penicillin. It is not yet ascertained whether the occasional positive skin reactions and urticaria to Ro 6-0787 may have been due to aggregation, or incomplete dissolution of the compound or whether it reflects hypersensitivity to another antigenic determinant. With the reservation that patients with positive skin test to Ro 6-0787 have for the time being to be excluded from combined treatment, this monovalent hapten certainly offers a new possibility to resume and/or pursue penicillin therapy in patients demonstrably allergic to that drug.

Adolescent↗
PubMedDate not supplied

[Bronchospasm therapy].

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Adrenal Cortex Hormones↗
PubMedDate not supplied

[Allergy and histamine release (author's transl)].

Histamine is released from mastocytes and basophils polymorphonuclears. This occurs particularly in reaginic type of allergy. The different phases of the reaginic process has been studied: IgE bridgings with antigens, cell membrane activation, cytoplasmic biochemical reactions involving cyclic AMP and GMP leading to microtubules activities, contraction of microfibrils and degranulation. Calcium and magnesium contribute to the regulation of histamine release. Histamine releases could also be seen in non reaginic type of immuns allergic reactions by way of direct or indirect activation of complements, by stimulation of PAF, etc...Finally, quite a few substances could also provoke histamine release of non immunologic type (physical agents, snake and bee venoms chemical substances in micro or macromollecular forms used in therapeutics...). Their mechanisms of action are various; yet in a way, they present similaritis with immunoallergic reactions. In practice, it is often difficult to assert the allergic nature of a histaminic reaction. Immunologic evidences should be cautioniously searched before any conclusion.

Basophils↗