PubMed Health⌕ Search

Biomedical subjects

J P Guay

Publications and source records attributed to J P Guay.

12 recordsLinked to original sources
PubMed2001

Victim-choice polymorphia among serious sex offenders.

The victim-choice polymorphia of 178 sexual aggressors divided into six subtypes, incest offenders, pseudoincest offenders, sexual aggressors of familiar children, sexual aggressors of unfamiliar children, sexual aggressors of familiar women, and sexual aggressors of unfamiliar women, was compared. Results showed that sex offenders remained stable in their choice of victim from one offence to another in terms of victim age, victim gender, and aggressor-victim relationship. Subjects characterised by high levels of polymorphia were pseudoincest offenders and sexual aggressors of familiar women, whereas sexual aggressors of both unfamiliar women and unfamiliar children were characterised by low levels of polymorphia. Recommendations regarding how to further refine sex offender typologies are discussed.

Adolescent↗
PubMed1994

Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy.

Between 1977 and 1992, we performed ninety-two synoviortheses (destruction of synovial tissue by intra-articular injection of a radioactive agent) on forty-eight patients who had a severe congenital disorder of hemostasis and chronic hemophilic synovitis that was resistant to conventional treatment. Colloidal 32P chromic phosphate was injected intra-articularly: 1.0 millicurie for knees and 0.5 millicurie for other joints. The duration of follow-up ranged from one to fifteen years. The frequency and importance of bleeding decreased in most of the patients. The range of motion of half of the joints remained stable or improved and that of the other half continued to decrease. Radiographic scores worsened progressively despite the decreased frequency of hemarthrosis. In most patients, the extra-articular leakage of the radioactive agent was slight. Chromosome breakages were observed almost exclusively in patients who were seropositive for human immunodeficiency virus and in whom the CD4-lymphocyte count was decreased from normal. The patients' level of satisfaction with the results was high.

Adolescent↗
PubMed1985

Synoviorthesis with colloidal 32P chromic phosphate for hemophilic arthropathy: clinical follow-up.

Thirty-one synoviortheses were performed in 22 joints of 14 hemophilic patients (aged 12 to 28 years) with chronic synovitis and for whom "conventional treatments" were considered ineffective. Except for patients with inhibitors, conventional treatments included three to six months of adequate prophylactic therapy with the missing coagulation factors, intensive physiotherapy and, when indicated, antiinflammatory agents and orthosis. Colloidal 32P chromic phosphate was injected intraarticularly in doses of 1.0 mCi for knees and of 0.5 mCi for the other joints. Time of follow-up ranged from two to five years. Frequency and importance of bleeding decreased in all patients. Effect on range of motion was best in knees; six of the seven treated improved and one was unchanged. In elbows, flexion-extension was improved in four cases, unchanged in five and decreased in one; pronation-supination was decreased in four cases. Range of motion was not affected in shoulders and ankles except for internal-external rotation which was improved in two of three shoulders treated. The results of 13 synoviortheses in four hemophilic patients with high titer factor VIII inhibitors were comparable to those in hemophiliacs with no inhibitors. However, in three of the four patients synoviorthesis had to be repeated after two to four years for recurrence of synovitis. Extraarticular escape of radioactivity was monitored 62 times for 17 synoviortheses in 12 patients; extraarticular counts never exceeded 4% of the intraarticular counts. Chromosome aberrations were found not to be increased after treatment in the seven patients in whom adequate analysis could be done.

Adolescent↗
PubMed1975

Survival in localized nodal and extranodal non-Hodgkin's lymphomata.

A retrospective analysis of 133 patients with localized nodal and extranodal non-Hodgkin's lymphomata whose staging investigations included marrow aspirate and lymphography shows that more than 60% remain alive and disease-free 4 years after initial therapy. Further relapses may occur in this group, particularly in the nodular lymphomata, but so far the majority of relapses and three quarters of the deaths from disease have occurred within 2 years of diagnosis. Of the entire group of patients, only 15% showed an unequivocally nodular pattern and a further 25% a partially nodular, partially diffuse pattern. Thus, 60% of patients had diffuse lymphoma but differences were observed depending upon the site of presentation. In the nodal Stages I and II cases, whereas only 4 of 55 patients with supradiaphragmatic disease showed a nodular pattern, 12 of 24 infradiaphragmatic presentations had nodular lymphoma. This difference was reflected in a lower relapse rate in the latter group. Mediastinal involvement was uncommon but carried a grave prognosis. As far as it was possible to judge, extension to adjacent nodal areas as a cause of relapse was not a common problem and, as observed previously, relapse was much commoner to a wide variety of extranodal sites than is the case with Hodgkin's disease. In this series marrow involvement was documented in only 7 patients but this surprisingly low frequency might be due in part to infrequent marrow sampling after the initial investigations were completed.

Adult↗