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Biomedical subjects

J P Hardouin

Publications and source records attributed to J P Hardouin.

At least 19 recordsLinked to original sources

[Tropical sprue. Apropos of a case observed in the Paris region].

A case of tropical sprue in a 73-year old parisian male returning from endemic areas is reported. Clinical manifestations were megaloblastic anemia, malabsorption and protein-losing enteropathy. Biopsy of the jejunal mucosa showed partial villous atrophy with thickening of the basement membrane region; fat droplets were observed inside and close to the epithelial cells on electron microscopy study. Fat intestinal absorption after a test meal was delayed. Clinical, biological and histological improvement was obtained with tetracycline and folic acid therapy. The particular clinical and anatomical features of this case, as well as the difficulties for establishing the diagnosis of tropical sprue in non-endemic areas are analyzed.

Aged↗

[Primary hepatic carcinoma disclosed by Budd-Chiari syndrome. Apropos of a case. Review of the literature].

Hepatic carcinoma revealed by Budd Chiari syndrome in an eighty-four-year-old female patient is reported. With reference to this observation and to the twenty-two other cases previously reported in the medical literature, the specific pathological and clinical features of Budd Chiari syndrome caused by primary carcinoma of the liver are reviewed. Histological features of the liver tumour are discussed.

Aged↗

[Inverted polypoid hamartoma of the rectum in a child].

Hamartomatos inverted polyps of the rectum were observed in a 12 years-old boy suffering from recurrent rectal discharges of mucus. Diagnosis was made on examination of rectal specimens obtained by local excisions and finally by recto-sigmoïdectomy, showing ectopic lobulated glandular structures deep to the muscularis mucosae. This histological aspect must be differentiated from adenocarcinoma, but in the paediatric age, prognosis depends on the degree of diffusion of the hamartomatous tissue, which may lead to extensive surgery such as recto-sigmoïdectomy. Whether this lesion is dysgenetic or acquired is discussed, and what relation can be presumed with solitary ulcer of the rectum is not clear.

Adolescent↗