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Biomedical subjects

J P Homasson

Publications and source records attributed to J P Homasson.

53 records · Page 3Linked to original sources
PubMed1982

[Sequential chemotherapy and radiotherapy modalities in small cell lung carcinoma. Preliminary results].

Two non randomized therapeutic trials have been conducted in oat cell carcinoma of the lung with limited disease. The first protocol combined chemotherapy (adriamycin, cyclophosphamide, VM 26, procarbazine) with mediastinal and supra-clavicular radiotherapy in classical fractionation (40 grays in 4 weeks). The second combined a more intensive chemotherapy (adriamycin, VP 16, methotrexate, cyclophosphamide) with an alternating radiotherapy (3 series of 15 grays). All patients received prophylactic brain irradiation. Preliminary results show a 9 month survival rate of 34 per cent and 62.5 per cent respectively. In addition, all patients in the second protocol presented a complete response at the end of the induction treatment. These preliminary data encourage proceeding with this kind of combined treatment.

Antineoplastic Agents↗
PubMed1982

Correlation between precancerous bronchial metaplasia and cigarette consumption, and preliminary results of retinoid treatment.

Vitamin A and its derivatives, so-called retinoids, can prevent squamous metaplasia induced not only by vitamin A deficiency but also by carcinogenic hydrocarbons. An aromatic retinoid, such as ET1, has been shown to prevent chemically induced papillomas in mice and to amplify certain immunologic reactions. Heavy smokers, 106 volunteers, were submitted to fibrobronchoscopy with bronchial biopsies. An index of metaplasia (IM) was calculated on the basis of microscopical examination of a total of 9,633 sections of 1,010 biopsies. Despite the subjectivity of the estimates of cigarette consumption, this was significantly (P less than 0.02) and positively correlated to the IM. Eighty-five percent of the women had a low IM as compared to only 42% of the men (P less than 0.01), although there was no significant difference in the reported cigarette consumption. Fifty-two subjects had an IM greater than 15% and were given 25 mg ET1 orally daily for 6 months. The bronchoscopy was repeated in 30 patients following completion of the 6-month treatment. The IM was significantly (P less than 0.01) reduced after treatment.

Adult↗
PubMed1975

[Diffuse interstitial pulmonary fibrosis. Responsibility of hard metals].

In a factory processing Tungsten carbide and hard metals, of a hundred exposed workers, 15 showed signs of "irritation" which progressed in 5 to clinical, radiological and functional pulmonary fibrosis with altered CO transport. In one patient histological sections were studied and typical findings of dust inclusion seen. Diffuse interstitial fibrosis related to heavy metals is still not yet recognised as an industrial disease in France.

Adult↗
PubMedDate not supplied

[Fine needle aspiration biopsy in pneumology. 351 punctures].

From 351 transthoracic punctures with a fine needle, the authors determine their method of exam. The cytologic study of the samples permits a positive diagnosis of pulmonary opacity for 60 p. cent to 70 p. cent of the cases. The rentability reaches 89 p. cent for malignant lesions. The complications with the fine needle are very unusual comparatively to the technics allowing a histologic study, although rentability is equal for these two methods.

Biopsy, Needle↗