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Biomedical subjects

J P Junod

Publications and source records attributed to J P Junod.

At least 19 recordsLinked to original sources
PubMed1988

Comparison of midazolam and oxazepam as hypnotics in elderly hospitalized patients. A double-blind clinical trial.

The efficacy and safety of 15 mg midazolam versus 15 mg oxazepam were compared in a double-blind clinical trial in 61 aged hospitalized patients (mean age 82.5, range 69 to 96), suffering from moderate to severe insomnia. The study covered 8 nights, i.e., 1 placebo night followed by 5 treatment nights and 2 further placebo nights. Both drugs were equally effective with respect to total sleep time, number of nocturnal awakenings, quality of sleep, condition on awakening, patients' assessment and dreams. However, sleep latency was significantly shorter in the midazolam group, which was also rated significantly more favorably by the medical staff. Side effects were mild and similar in both groups. No rebound or carry-over effects were noted. Midazolam can be considered an effective and safe sleep inducer in aged patients.

Aged↗
PubMed1982

[Geriatric training in Swiss medical departments].

Medical training in the geriatrics sector responds to a real and pressing necessity. The Swiss Gerontological Association has therefore set up a commission to investigate the basic features of a course of this nature and its implementation. The present report analyses the initial recordings.

Curriculum↗
PubMed1981

[Particulars in the medical treatment of geriatric patients].

During geriatric treatment, the use of medicaments is often important, sometimes harmful, and seldom sufficient by itself. In order for the treatment to be successful, its indication must be well-founded. The dosage has to be adapted, and restraint and therapeutic discipline should always be encouraged. Finally, the anticipated advantages must be greater than the various possible side effects.

Aged↗
PubMed1979

[is there an osteomalacia component in femur neck fractures?].

In 29 patients with fractures of the femoral neck (group A) and 22 patients operated on for osteoarthritis of the hip (group) B), plasma levels of 25-hydroxycholecalciferol (25-OH-D3) were compared with the results of histological bone tests. A third group of 19 patients at the Geriatric hospital served as a control in this age group for 25-OH-D3 values (group C). The average level of 25-OH-D3 was 9.64 +/- 5.8 micrograms/l in group A and 13.25 +/- 7.6 micrograms/l in group B. This difference is not significant. On the other hand, the difference between groups B and C (9.31 +/- 4.04) is significant (2 p less than 0.05). Evaluation of the histological sections did not reveal evidence of osteomalacia. Generally speaking, the levels of plasma 25-OH-D3 in these patients were low, but without signs of osteomalacia on histological evaluation.

Aged↗
PubMed1978

[Hyperthyroidism in older patients].

This study comprises 81 thyrotoxic patients with onset after the age of 60. In elderly persons, toxic multinodular goiter is the most common cause (68%) of hyperthyroidism, followed by solitary thyroid nodules (16%) and Graves' disease (16%). Cardiovascular disorders (cardiac failure, arrythmias etc.) constitute the first and often the only symptom in 62% of the cases. The other forms of appearance are both various and deceptive: depression, slight fever, asthenia or nausea. Separate analysis of the three forms of hyperthyroidism did not reveal clinical, biological or therapeutic differences between them, except an inferior rate of captation for the toxic nodules. Isolated measurement of T3 or T4 is often insufficient to confirm the diagnosis because either of these hormones may appear at a normal rate. In three cases only the free thyroxin index was pathological on first determination. The authors have established that the autonomous nodules are larger and more active after, rather than before, 60 years of age, and have attempted to define their morphological identity. The results of the treatment are analyzed and preference is expressed for radioactive iodine in every form of hyperthyroidism.

Aged↗
PubMed1977

[Confusional states in geriatrics].

Illustrated by clinical reports, this study attempts to demonstrate the practical and didactic interest of various somatopsychological correlations in geriatrics. The confusional state in the elderly has no specific etiopathogenesis. It is only the expression, often disconcerting, of a method of cerebral suffering and the clinician should be aware of its various presentations. The precipitating factors are not only of organic or iatrogenic origin, but often psychological. Any change is considered by the elderly patient as dangerous and worrying. Our perfectly justified fear of inaction and passivity together with a desire for rapid efficacy, should not lead us to forget that in geriatrics more than in any other branch of medicine, a prudent attitude in therapeutics is most likely to be successful.

Adaptation, Psychological↗