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Biomedical subjects

J P Max

Publications and source records attributed to J P Max.

25 records · Page 2Linked to original sources
PubMed1983

[Effects of diets containing medium-chain and long-chain triacylglycerols in the genetically obese Zucker fa/fa rat. Composition of fatty acids and triacylglycerols of the liver and adipose tissues].

The effects of a hyperlipidic diet containing medium-chain triacylglycerols (MCT) or long-chain triacylglycerols (LCT) and a control diet on the lipid composition of liver and adipose tissue in the Zucker fa/fa and Fa/- rat are compared. The weights of liver and adipose tissues of the rats fed the MCT diet are little different from those of the two other groups, but they are always higher in obese rats than in lean rats. After feeding the MCT diet, the amounts of the constituent octanoic and decanoic acids in liver and adipose tissues are higher in the fa/fa rat than in the Fa/- rat. The rate of lipogenesis in liver and adipose tissues of the obese rat fed the MCT diet remains high.

Adipose Tissue↗
PubMed1983

Modifications in apoprotein C composition of very low density lipoproteins in type IV hyperlipoproteinemic subjects after dietetic triglyceridemia reduction.

Variations in peptide composition of apoprotein C from very low density lipoproteins were studied in 10 type IV hyperlipoproteinemics, before and after triglyceridemia normalization through appropriate diet. The subjects were sensitive to carbohydrates or alcohol : a reduction or elimination of the inducing nutrient led to a decrease in serum triacylglycerol levels, correlated with an increase in the proportion of apo CII and a decrease in the proportion of apo CIII1. Apo CIII2 was not affected. This led to an increased ratio, apo CII/apo CIII1. The percentage of variation of different lipid (triacylglycerols and cholesterol) and protein (apoproteins CII, CIII2) parameters were also studied.

Adult↗
PubMed1983

Effect of reduction of triacylglycerol level on fatty acid and glucose incorporation into human adipose tissue in type IV hyperlipoproteinaemia.

The fatty acid incorporation into adipose tissue (FIAT) and glucose incorporation into adipose tissue (GLIAT) have been measured in 11 patients suffering from Type IV hyperlipoproteinaemia during the hypertriglyceridaemic phase (HTG) and after normalization of triacylglycerol (TG) levels as a result of a diet which was adapted to the nutritional response of subjects. Results have been compared with those obtained in 10 reference subjects. During the HTG phase FIAT and GLIAT activities were significantly lower than in the case of reference subjects: FIAT (76.5 vs 185 nmol divided by 3/g adipose tissue/h, GLIAT (92.5 vs 208 nmol x2/g adipose tissue/h). After reduction of HTG, these activities increased in a significant way, FIAT (137.7 vs 76.5 nmol divided by 3/g/h) and GLIAT (160 vs 92.5 nmol X 2/g/h). These results agree with the hypothesis that the reduced incorporation of fatty acids and glucose into adipose tissue, measured in vitro, is partly due to the modification of the profile of lipoproteins and apoproteins related to hypertriglyceridaemia.

Adipose Tissue↗
PubMed1983

Effects of medium- and long-chain triacylglycerols on adipose tissue metabolism in the obese Zucker rat.

The influence of a diet including 18 per cent by weight of long-chain (LCT) or medium-chain (MCT) triacylglycerols on adipose tissue development, and on in-vitro adipose tissue triacylglycerol (TG) synthesis from glucose and palmitic acid, was studied using genetically obese, fa/fa, and control, Fa/-, Zucker rats. The adipose tissue mass was greater with the LCT diet than with either the MCT or control diets, but there was no significant difference between the MCT and control diets. TG synthesis from labelled substrates was not modified by the MCT diet when compared with the control, but was decreased by the LCT diet. The results suggested that the use of MCT in treating human obesity would necessitate levels too high to be therapeutically practical.

Adipose Tissue↗
PubMed1982

[Effect of moderate protein deficiency on reproduction in the female rat and on the development of the pups until weaning].

Two groups of Wistar female rats were respectively fed ad libitum a standard stock diet containing 22 p. 100 protein (n = 93) and a diet containing 7.5 p. 100 protein (n = 189) for 8 weeks. They were mated with male rats of the same strain after 2 weeks of these diets. A small decrease (8 p. 100) in fecundity was observed but this moderate protein deprivation did not affect either the litter size (9.68 +/- 3.50 vs 9.61 +/- 3.69) or the percentage of stillborn pups (4.8 vs 4.9 p. 100). The postnatal mortality of the pups of deprived dams was much higher than that of pups from normal dams (11.2 vs 0.9 p. 100). During the suckling period, the 7.5 p. 100 protein diet did not cover the requirements of the dams. They lost 20 p. 100 of their weight, whereas the weight of the dams fed the 22 p. 100 protein diet remained stable. The weight deficit of the young rats born from deprived dams was about 10 p. 100 at birth but it rose to 50 p. 100 at weaning. During the gestation and suckling periods, the maternal body stores and tissues were mobilized to assure the growth of the young.

Animals↗
PubMed1981

Correlations between the apoprotein C composition of very-low-density lipoproteins and triglyceridemia in subjects with type IV hyperlipoproteinemia.

The protein composition of apoprotein C regarding peptides CII, CIII1, and CIII2 has been studied in VLDLs in 59 normal or hypertriglyceridemic subjects. The percentages of the peptides found in each subject were correlated with serum triacylglycerol levels. There are very good correlations between the proportion of VLDL apo CII and triglyceridemia (r = -0.63) and between the proportion of CII1 and triglyceridemia (r = 0.66). The proportion of apo CII decreases as triacylglycerol level increases, whereas the proportion of apo CII1 increases under the same conditions. The percentage of apo CII2 varies in the same way as does apo CII, but to a lesser degree. The apo CII/CIII1 and apo CIII2/CIII1 ratios decrease as triglyceridemia increases. In contrast, the apo CII/CIII2 radio, though reduced, is not significantly modified. Mechanisms are reviewed that could lead to changes in apoprotein C in subjects with hyperlipoproteinemia, and the possible relationship with lipoprotein lipase activity is discussed.

Apolipoproteins↗