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Biomedical subjects

J P Novati

Publications and source records attributed to J P Novati.

12 recordsLinked to original sources

[Metastatic pulmonary choriocarcinoma and pulmonary arteriovenous aneurysm].

Pulmonary metastases from a uterine choriocarcinoma are rare in France. The authors report a case of a 42 years old patient who presented more than four years after her last pregnancy with a metastasis in the left lower lobe due to a uterine choriocarcinoma. There was a favourable outcome after combined treatment with chemotherapy and surgery. The patient had been in hospital eighteen months earlier for a spontaneous left haemothorax secondary to a ruptured intrapleural pulmonary arterio-venous aneurysm (AVV) of the left lower lobe which was treated by embolisation. The aetiology of pulmonary AVV are defined, and the pathophysiology of uterine carcinoma as well as the probable association and pulmonary vascular anomalies are discussed.

Adult↗

[Pericardial mesothelioma. Apropos of a case].

A 74 year old woman without previous cardiovascular disease presented with pericardial effusion and tamponade. Two-dimensional echocardiography displayed a pericardial mass, but a diagnosis of tumour was not envisaged. Pericardiocentesis produced an exudative fluid with lymphocytes but no malignant cells. Pericardial biopsies through axillary thoracotomy indicated chronic progressive pericarditis. As the patient's haemodynamics deteriorated, sternotomy was carried out showing diffuse pericardial sclerosis corresponding, at histology, to a mixed, predominantly fibroblastic pericardial mesothelioma. The authors describe the main clinical characteristics of pericardial mesothelioma, always discovered belatedly at surgery or necropsy. They insist on the value of non-invasive methods (two-dimensional echocardiography, computed tomography) to diagnose a pericardial tumour, and on the poor prognosis of mesotheliomas, treatment still being uncertain due to the small number of cases and to the early occurrence of cardiac complications.

Aged↗

[Localized intestinal lymphangiectases presenting as peritonitis].

The authors report a case of localised intestinal lymphangiectases in a segment of jejunum with the unusual presentation of an acute perforation. The anatomical findings did not provide a satisfactory aetiopathogenic explanation, although the most likely hypothesis is a past history of abdominal irradiation. The mechanism of the perforation also remains unclear and the presence of microscopic lesions in the wall of the remaining small intestine raises the problem of the long-term prognosis.

Adult↗

[Aorto-bi-iliac resection, of the 3rd part of the duodenum and the left colon, for recurrence of colonic cancer].

An aorto-bi-iliac resection was performed in a patient with recurrent cancer of the left colon. Implantation of a Dacron vascular prosthesis was combined with left iliac colostomy and resection of 3rd part of duodenum. Based on this case and a review of the literature, the possibility and value of resection of an invaded vascular axis is emphasized. The revascularization procedure, either by a prosthesis in situ or associated extra-anatomical by-pass, is discussed.

Adenocarcinoma↗