Biomedical subjects

J P Peña

Publications and source records attributed to J P Peña.

3 recordsLinked to original sources

PubMedDate not supplied

[Colonic adenoma: risk factors for their malignant transformation].

BACKGROUND: Almost all colorectal cancers develop from adenomatous polyp, its detection and resection prevent the malignization. Several adenoma characteristics like: number, size, morphology, histologic type and grade of dysplasia have become considered as malignization risk factors. AIMS: This study was designed to determine the frequency of colorectal adenoma and the principal risk factors for malignization. METHODS: Between June of 1989 and July of 1994, 846 colonoscopies were performed and retrospectively analyzed in the same number of patients. The patients with colorectal polyps were chosen for the analysis of this study as well all the polyps characteristics, to determine the risk factors for malignization. RESULTS: There were 183 patients (21.6%) with 322 colorectal polyps. Of all of them, only 214 (66.4%) underwent colonoscopy snare resection and were studied; 120 (57%) were neoplastic polyps and 94 (43%) non neoplastic; among those neoplastic polyps, 100 (83.4%) were tubular adenomas, 11 (9.1%) were tubulovillous adenomas, and 9 (7.5%) were villous adenomas. We found 16 (7.4%) polyps with adenocarcinoma, 14 (87.5%) were found in patients older than 50 years of age and in polyps larger than 1 cm in diameter (p 0.040). Eleven (68.7%) were sessiles (p 0.001). CONCLUSIONS: After the evaluation of polyps, the tubular adenomas were the neoplastic polyps more frequently found. In this particular study, the patient age, polyp size and morphology were the more statistically significant risk factors for malignization in our patient group.

Adenoma↗

PubMedDate not supplied

[Colitis cystica profunda. A case report].

OBJECTIVE: To present a pathology not previously informed in national literature. BACKGROUND: Colitis cystica profunda (CCP) is a rare benign entity and with an unknown etiology. There are 148 cases documented in world literature at the present time. Histologically it is defined as the obliteration of lamina propria by fibroblasts and the presence of submucous cysts. It comes in localized, segmental or diffuse forms and associated to other entities as solitary rectal ulcer, rectal prolapse, alterations in the pelvic floor, etc. Treatment can be medical or surgical according to severity of its manifestations. METHOD: A case of CCP is revised as well as the treatment effectuated. RESULTS: A case of patient with the diagnosis of CCP of localized type is presented, which principal symptom was transanal mucous secretion; on physical exploration a sessile mucous polypoid formation at 8 cm from anal verge was found and was treated with surgical resection with a satisfactory outcome. CONCLUSIONS: In a patient with alterations in pelvic floor or puborectal bundle contraction and sigmoidorectal intussusception CCP must be suspected. Treatment can be medical with a high percentage of failure being optimal treatment the surgical one.

Adult↗

PubMedDate not supplied

[Associated clinical features in 41 patients with anal epidermoid carcinoma, studied at a cancer center].

OBJECTIVE: To investigate the main associated clinical characteristics in a group of patients with squamous cell carcinoma of the anus. BACKGROUND: Anal carcinoma is associated with sexually transmitted viral carcinogenesis. MATERIAL AND METHODS: We analyzed the charts of patients with squamous cell carcinoma of the anus treated during 1994 and 1995. Demographic characteristics, presence of HIV-1, sexual behavior and the presence of anal warts were analyzed. RESULTS: There were 41 patients, 26 females and 15 males with a mean age of 61 and 45 years respectively. Twenty-three patients (56%) had history of anal intercourse, 17 (41%) had anal warts and 12 (29%) were HIV-1 (+). This factors were observed more frequently in the male population (p < 0.001). The patients who had anal intercourse had more frequently anal warts and HIV-1(+) compared with those who did not (p < 0.001 in both). The HIV-1 (+) patients had more frequently anal intercourse and anal warts than those HIV-1(-) (p < 0.001 in both). CONCLUSION: 1) male population develop squamous cell carcinoma of the anus earlier than female population, 2) there is a high incidence of homosexuality, anal warts and HIV-1(+) in the male population; these findings suggest different mechanism of carcinogenesis in both gender.

Aged↗