Biomedical subjects

J P Pilgrim

Publications and source records attributed to J P Pilgrim.

4 recordsLinked to original sources

PubMed1985

Primary mucinous carcinoma of the skin with metastases to the lymph nodes.

Primary mucinous carcinoma is a rare sweat-gland neoplasm of the skin with a tendency to grow slowly. Although the neoplasm persists locally in nearly half of the cases after attempts at removal, metastases to regional lymph nodes and widespread metastases are uncommon. We present a case of primary mucinous carcinoma in an axilla with metastases to the axillary lymph nodes and propose a hypothesis explaining the slow rate of growth, based on our findings of a paucity of both blood vessels and macrophages in the neoplasm. Electron microscopy revealed mucin production by the dark cell and its extracellular secretion, which supports the theory of eccrine differentiation of the neoplasm.

Adenocarcinoma, Mucinous↗

PubMed1984

A simplified hyperbaric oxygen technique for leg ulcers.

A modified technique for administering hyperbaric oxygen with the use of disposable polyethylene bags was evaluated for the treatment of arterial leg ulcers. The potential advantages of the method include fairly low expense, lack of cross-infection, and simplicity in the administration of oxygen. Six men with 27 chronic arterial ulcers were treated with this technique, and five men (ten ulcers) served as controls. In the treated group, 18 of 27 ulcers (5/6 patients) were healed within six to 21 days, with 50% to 90% reduction in size of seven of nine of the remaining ulcers after a three-week period. None were healed in the control group. The treated ulcers healed by 7.8% +/- 1.15% per day compared with -0.5% +/- 0.37% in the control patients. The results indicate that our technique of administering hyperbaric oxygen for the treatment of leg ulcers is simple and effective. It can be adapted for either inpatient or outpatient treatment.

Adult↗

PubMed1982

The tricuspid valve annulus: study of size and motion in normal subjects and in patients with tricuspid regurgitation.

The tricuspid valve leaflets and their annular attachments were recorded by two-dimensional echocardiography from a view of the right ventricular inflow tract obtained by placing the transducer at an intermediate position between the left ventricular apex and the left lower sternal border. The transducer was rotated, and recordings were made at 30 degrees rotational intervals around the circumference of the tricuspid valve annulus. The cyclical pattern of variations in tricuspid annular size was studied with 12 measurements made during the cardiac cycle in five normal subjects. Annular areas and circumferences were measured. The overall motion pattern was similar to that reported in normal mitral valve annular study. Subsequently, in 16 normal subjects and 18 patients with tricuspid regurgitation, the maximum and minimum tricuspid annular sizes and their percent reduction were measured. The mean maximum annular circumference and area were 11.9 +/- 0.9 cm (mean +/- SD) and 11.3 +/- 1.8 cm2 in normal subjects. They were significantly greater in tricuspid regurgitation (14.0 +/- 0.7 cm and 15.8 +/- 1.8 cm2, respectively). The mean minimum annular sizes were much larger in tricuspid regurgitation (12.5 +/- 0.6 cm and 13.0 +/- 1.4 cm2) than in normal subjects (9.6 +/- 0.9 cm, 7.6 +/- 1.4 cm2). Thus, the percent reduction of annular circumference and area were significantly decreased in tricuspid regurgitation. For anatomic correlations, measurements of the tricuspid annular circumference were made at autopsy in 18 hearts without underlying valvular disease. The annular circumference was measured in the fresh and fixed states. The measurement in the fresh state was 13.5 +/- 0.8 cm and in the fixed state was 12.0 +/- 0.8 cm. The values measured in the fixed hearts were more similar to measurements obtained by echocardiography in a group of normal subjects. Thus, tricuspid annular reconstruction by the new two-dimensional echocardiographic method provides additional information about normal and abnormal size and function of the tricuspid valve annulus.

Adult↗

PubMed1974

The regulation of cellular volume in liver slices.

1. Rat, rabbit and guinea-pig liver slices were incubated in media at 37 degrees C to study effects of ouabain and of metabolic inhibition on tissue composition.2. Slices initially incubated in oxygenated balanced medium did not swell when exposed to either balanced media or potassium-free media containing ouabain in concentrations ranging from 0.1 to 10 mM though they lost potassium and gained a comparable amount of sodium.3. Without prior incubation in oxygenated medium slices initially swelled when incubated with ouabain but then maintained their new volume.4. Slices whose metabolism was inhibited by incubation with nitrogen and 1 or 10 mM iodoacetamide lost as much potassium as slices exposed to 10 mM ouabain but became swollen with the uptake of sodium, chloride and water.5. The results show that liver cells, like renal cortical cells, possess a metabolically dependent, ouabain-insensitive, potassium-independent mechanism concerned in the regulation of cellular volume.

Acetamides↗