[Formation of surfactant in the fetus and newborn infant].
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Chemical Phenomena↗
Biomedical subjects
J P Relier
Publications and source records attributed to J P Relier.
[Unilateral interstitial emphysema in the newborn (apropos of 4 case reports)].
Four prematurely born neonates who where mechanically ventilated with CPAP for respiratory distress have developed severe unilateral pulmonary interstitial emphysema. Some particular circumstances can be pointed out in these cases. Spontaneous worsening is usual. Selective bronchial intubation protects the overinflated lung. It allowed total improvement of the lung function for the 3 cases who underwent this treatment. Although no major complications have been noticed, it is mandatory to suck out regularly bronchial secretions accumulated in the excluded lung.
Female↗
[Neonatal listeriosis. Apropos of 53 cases].
53 cases of neonatal listeriosis were seen during the last five years at the Intensive Care Unit for newborn infants (Pr Minkowski) and the Neonatal Center (P. Varangot) of the Port-Royal Maternity Hospital. The significant decline in mortality to 22 p. 100, when compared with previous years, was attributed to improvements in the diagnosis during the first hours of life and the contribution of artificial ventilation. The most frequent initial clinical sign was respiratory distress (58 p. 100) whereas meningitis was relatively rare (11 p. 100). Discoloration of the amniotic fluid and a fever in the mother at the time of delivery, were also important diagnostic clues. The macroscopic examination of the placenta and particularly placental smears containing listeria monocytogenes (15 of the specimens) as well as the hematological alterations, particularly an increase of the fibrinogen level above 3-4 g/1 during the first 48 hous of life (72 p. 100 of the cases) contributed to an early diagnosis.
Female↗
[Intraventricular hemorrhages in hyaline membrane disease].
Twenty prematures children with hyaline membrane disease treated by artificial ventilation under continuous alveolar distension pressure, died after intra-ventricular hemorrhage (group I). These cases have been compared to 20 surviving children, with respiratory diseases of similar severity, and supposed to be uninjured with regard to such cerebral lesions (group II). During the first two days of life, the frequency of important hypothermia, hemodynamic instability with tendency to collapse, metabolic or mixed recurring acidosis were significantly more frequent in group I than in group II. These abnormalities probably promote bleeding; their practical consequences are discussed. On the other hand, perinatal suffering and distrubances in blood coagulation do not take a determinant part. The further aggravation of the neurological status, after an lay phase, unexplained and important hematocrit drop, presence of blood at lumber puncture and, overall, at the electro-encephalogram rolandic sharp spikeswaves constitute the major arguments for the diagnosis of hemorrhage.
Acidosis↗
[The measurement of total blood cell volume in newborns with respiratory distress].
The total blood cell volume was measured with 51Cr labelled red blood cells in 52 premature newborns, divided into 3 groups, with similar gestational ages and birth weigths: 15 controls, 11 children with transitory respiratory distress and 26 with hyaline membrane disease. The total red blood cell volumes were significantly different (p less than 0.001) in newborns with hyaline membrane disease (32.12 ml/kg +/- 8.75). No hypothesis explaining these results was satisfactory. However, early blood transfusion in children with hyaline membrane disease may be proposed as a practical application.
Blood Volume↗