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J P Rouget

Publications and source records attributed to J P Rouget.

16 recordsLinked to original sources
PubMed1986

[Inhibitors of factor VIII in non-hemophilic patients. Biological and therapeutic aspects. Apropos of 3 cases].

A coagulation inhibitor of the anti-factor VIII: C type was detected in three non-haemophilic male patients aged 75, 70 and 52 respectively. In all three patients antibody titres were low (less than 12.5 Bethesda units initially, less than 20 units subsequently), and a low but detectable level of factor VIII: C persisted (7 to 12 p. 100 in two patients who had severe haemorrhages and 2.100 in the third one). The 3 inhibitors inactivated factor VIII: C with a complex, type II kinetics (Biggs et al.). Strong doses of anti-haemophilic A fractions were biologically effective in one patient but could not stop severe bleeding. Activated plasma fractions were used successfully on several occasions. Once, moderate and repeated doses of anti-haemophilic A fractions resulted in satisfactory correction of factor VIII: C level, and a minor surgical operation could be performed. An immunosuppressive treatment was administered for 3 weeks to one patient and for 3 months to the other two patients. In all three cases the inhibitor disappeared after 5 to 8 months. In non-haemophilic patients with factor VII: C inhibitor the treatment of haemorrhagic episodes must take into account the severity of bleeding, then the usually complex kinetics of the inhibitor; thus it cannot be a direct copy of the treatment used in haemophiliacs with type I inhibitors.

Aged↗
PubMed1983

[Behçet's disease and vascular malformations: double etiology of recurrent thrombophlebitis].

Repeated thrombophlebitis with pulmonary embolism in a 28-year-old female led to the discovery of a complex malformation of the inferior vena cava which required the insertion of a clip. Three years later, recurrence of phlebitis with appearance of bipolar aphthae, arthritis and a meningeal syndrome led to the diagnosis of Behçet disease. Despite various medications for this disorder and heparin or oral anticoagulant therapy, the thromboembolic disease remained active, accompany with new exacerbations of Behçet disease. Diminished plasma fibrinolytic activity was demonstrated, probably resulting from venous endothelial vascularitis, which aggravates the consequences of the preexisting vascular malformation.

Adult↗
PubMed1983

[Necrotizing angiitis after serous otitis. 2 cases].

Two cases of systemic necrotizing angeitis are reported because of their very unusual presenting symptom: serous otitis media responsible for bilateral deafness. After this "invasion phase", typical polyarteritis nodosa developed. Cardiac involvement, with auriculoventricular block, and cranial neuritis were observed in both cases. The few previously published identical cases are reviewed. Specific neurological and cardiac forms of P.A.N. are discussed. It is hypothesized that the cause of this immune complex-mediated disease is infectious.

Adult↗
PubMed1983

[Hypothyroidism and the Gougerot-Sjögren syndrome].

The signs of Sjögren's syndrome were systematically researched in 36 patients with hypothyroidism (myxoedema with atrophic thyroiditis in 32 cases, Hashimoto's thyroiditis in 4). In a quarter of these patients were noted separately submaxillary glands and/or parotids enlarged, buccal and/or lacrymal sicca syndromes, and antisalivaryy ducts antibodies. The histologic analysis of minor salivar glands revealed foci of lymphocytes and plasmocytes (grades 3 and 4 of Chisholm's classification) in 6 subjects. Similarities between the Sjögren's syndrome and the autoimmune thyroiditis were specified; their association in the same patients might be explained considering the genetic predisposition to these affections.

Adult↗
PubMed1983

[Circulating anticoagulant, recurrent abortions and venous thrombosis: a new entity or a pre-lupus syndrome? 2 cases].

The authors report the presence of a circulating anticoagulant in two patients who had suffered multiple abortions. The circulating anticoagulant was discovered during evaluation of repeated phlebothromboses in the first case and of a chronic inflammatory syndrome in the second. While the apparently paradoxical relationship between the circulating anticoagulant and venous thrombosis is relatively well-known, that between the circulating anticoagulant and repetitive abortions is more difficult to establish. The rarely reported association of these three events leads us to a discussion of the nosologic place of this pathology and of the common ground it shares with S. L. E., as the circulating anticoagulant is of the antiprothrombinase variety, the antibody commonly called the lupus anticoagulant.

Abortion, Habitual↗
PubMed1979

[Paravertebral hematopoietic pseudotumor during Paget's disease (author's transl)].

Extramedullary hematopoiesis is usually secondary to a severe and prolonged reduction in medullary functions, but can be the rare consequence of an extrusion of tissue formed of weakened or fractured bone. The hematopoietic nature of this pseudotumor can be confirmed histologically or, as in this case of Paget's disease, by Indium scintigraphy which can define the specific locations of the hematopoietic marrow.

Aged↗
PubMed1978

[Hyponatremia].

Explore the source record for details and available documents.

Humans↗
PubMedDate not supplied

[Value of the analysis of lipoproteins after myocardial infarction].

Lipid and apoprotein constituents of plasma lipoproteins were determined in survivors of myocardial infarction in relation to a control population. Compared to controls, the patients had significantly higher concentrations of total triglycerides, VLDL + LDL - cholesterol and apo-B, but lower concentrations of HLD-cholesterol, HDL2-cholesterol, HDL3-cholesterol, apo A-I and A-II. Survivors with normal lipaemia also had perturbations in HDL and subfractions (HDL2 and HDL3). In addition, the patients exhibited a significant decrease in HDL-cholesterol to VLDL + LDL-cholesterol ratio and in apo A-I to apo-B ratio. These results demonstrate the importance of determining all lipoproteins in future biological studies to evaluate more precisely the relationship between these compounds and atherosclerosis.

Adult↗