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Biomedical subjects

J P Sackler

Publications and source records attributed to J P Sackler.

15 recordsLinked to original sources

Wilms' tumor metastatic to the mediastinum.

We report two children with mediastinal metastasis of Wilm's tumor. One case presented with a right hilar mass and the other with a posterior mediastina mass. In each instance, no additional radiologic evidence of metastasis was found. Metastasis of Wilms' tumor to the mediastinum is uncommon, usually occurring with radiologic evidence of either additional metastases or direct cephalad growth of the primary tumor.

Child, Preschool↗

Thyroid echography of subacute thyroiditis.

Ultrasound was used to study 10 patients with subacute thyroiditis. With gray-scale technique, a "washed-out" appearance was seen during the active phase of the active phase of the illness. Clinical migration of the inflammation was accompanied by migration of the sonographic abnormality. Ultrasound can be especially helpful in the diagnosis of unilateral subacute thyroiditis and the differentiation of true cysts from hemorrhagic degeneration of goiter.

Humans↗

Pulmonary disorders associated with Sjogren's syndrome.

Pulmonary disorders occur in 25 to 47 per cent of the patients with Sjogren's Syndrome. These are of two types: 1. related to the major connective tissue disorders which commonly accompany this syndrome, and 2. secondary to the peculiar underlying pathology of Sjogren's Syndrome i.e. sicca disorders of the lung. The latter is the more frequent type, occurring mainly in patients with protected sicca complex unaccompanied by a systemic connective tissue disorder, and consists of chronic bronchitis, subsegmental atelectasis, pneumonia, bronchiectasis, lymphoproliferative pulmonary infiltrates and chronic interstitial pneumonitis which may lead to pulmonary fibrosis. 21 cases of Sjogren's Syndrome, 9 of whom had evidence of pulmonary abnormality, are presented, including a case of interstitial pneumonitis leading to diffuse interstitial pulmonary fibrosis. A review of the literature is included.

Adolescent↗

The determination of electron density by the dual-energy Compton scatter method.

The intensity of Compton scattered photons is directly proportional to the electron density of a substance; therefore it is possible to detect changes in electron density by this noninvasive method. The source-detector geometry has been varied to study the effects of geometry on the calculated electron density values, using a 90 degrees scattering angle. The dual-energy Compton scatter method provides a determination of electron density in known samples, with an uncertainty of less than 1% for the optimal geometry. The effective linear attenuation coefficient for Compton scatter has been determined with an uncertainty of 2.1%-3.6% for the optimal geometry used. The applications of the dual-energy Compton scattering technique in radiotherapy dosimetry and skeletal bone densitometry are being investigated.

Electrons↗