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J P Seguela

Publications and source records attributed to J P Seguela.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Local production of specific antibodies in the aqueous humor in experimental Candida endophthalmia in rabbits].

An increasing frequency of ocular lesions due to Candida albicans has been reported, but clinical detection of lesions, which may cause permanent blindness, remains difficult. Hematogenous endophthalmitis caused by Candida albicans in the rabbit is a useful model to study the pathogenesis of the disease, and perhaps to find new methods of biological diagnosis. A suspension of Candida albicans was injected in 15 rabbits, according to the method described by Edwards et al. In 1975, causing uni or bilateral chorioretinitis in 12 of them. Unaffected eyes were chosen as controls. After aspiration of the anterior chamber fluid, serum and aqueous humour titres of specific antibodies were determined. A local synthesis of IgG antibodies was detected, after comparison of the titres of specific antibodies in the aqueous humour and in the serum, related to the serum and aqueous humour concentrations of IgG antibodies. According to a formula proposed by Witmer and Desmonts in ocular lesions due to different pathological agents, we calculated the "C" coefficient: C = antibody titres aqueous humor/serum x IgG serum/aqueous humor. A local synthesis of specific antibodies in cases of experimental endophthalmitis leads us to believe that aqueous humour aspiration could be used in the diagnosis of endophthalmitis in humans.

Animals↗
PubMed1985

[Toxoplasmosis in the African tropical zone. Preliminary studies].

Toxoplasmosis in Tropical African area was not subject to many publications but the results indicate that toxoplasmosis may influence the health of the populations. We present prevalence studies carried out in the Central African Republic, Mali, Niger, Burkina-Faso, Togo to find toxoplasma-antibodies by Agglutination of Latex. For adults the lower percentage was found in the North Central African Republic villages (40%) and the higher in Mali (nearly 70%). These high percentages justify a larger epidemiological study in Tropical Africa.

Adolescent↗
PubMed1985

[Toxoplasmosis in Japan. Comparative study of different regions].

Specificities of Japan by geography, culture, and low incidence for Toxoplasmosis were examined in this epidemiological study. 1 731 human sera were examined by several immunological tests but these results are related with Agglutination-Latex test. The sera came from North (Hokkaido), Middle (Tokyo area) and South (Okinawa). The ratio for the whole Japan towards Toxoplasmosis is 24.7% but the increase of antibodies with age is late: rate of positivity 4.6% up to 17 years old and nearly 30% after 30 years old. Cats, business, climate do not seem to influence the human infection. It is consumption of meat and particularly raw meat which influence the results: 40.8% positive results among eaters of raw meat and 22% among those not eating meat or eating it well cooked.

Adolescent↗
PubMed1985

[A proposed protocol for prevention of congenital toxoplasmosis adaptable in a tropical zone].

In Toulouse, various epidemiological works and biological results regarding toxoplasma infection permitted us to study immunity in pregnant women. 66 to 70% are immunized. Incidence of acquired toxoplasmosis is 1 to 2 for 1,000 pregnancies. Carefully planned, regionalized programs with obstetricians and pediatricians are realized to prevent congenital toxoplasmosis. Epidemiological studies may be realized to estimate the prevalence and the incidence of congenital toxoplasmosis before such programs can be recommended on a national scale in tropical area.

Female↗
PubMed1985

[Toxoplasmosis in the Central African Republic: first survey].

For this purpose, toxoplasma antibodies were determined by latex agglutination test. Two kinds of human sera were examined: people in "good health" from North of Centrafrican Republic and patients from Bangui. In North, 40% of sera gave positive results and young girls from 1 to 14 years old seem to become positive earlier than young boys. At Bangui, 81% of sera from pregnant women coming from Medical Service was positive; all from 8 patients with ocular affections was positive and only 5 on 10 with adenopathy.

Adolescent↗
PubMed1984

[Evaluation of normal protein profile of the mixed saliva and serum by laser nephelometry].

The aim of this study was to produce a protein profile of both whole saliva saliva and serum in a normal population of adults of both sexes ranging from 18 to 35 years of age using laser nephelometry. Twelve proteins were titrated: IgA, IgG, IgM, C3c, C4, alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, albumin, hapto-globulin, alpha 1-glycoprotein acid and transferrine. This study is an original attempt to define a normal protein profile in the healthy adult. The next stage will be to analyse the physiopathological variations of this profile in inflammed oral and dental diseases.

Adolescent↗
PubMed1983

Diagnosis of pigeon breeder's disease by indirect immunofluorescence on sections of pigeon oviduct.

A new technique by indirect immunofluorescence on sections of pigeon oviduct, is described as an aid to diagnosis of pigeon breeder's disease. It is easy to do, inexpensive, and permits distinction between affected patients and exposed but unaffected persons. The main allergen, pigeon IgA, participates in the fluorescent responses of the mucous membrane and associated secretions. It has been possible to relate changes in antibody titre with improvement following treatment.

Alveolitis, Extrinsic Allergic↗
PubMed1979

[Pulmonary mucormycoses (author's transl)].

Mucormycoses are rare, acute infections, most often fatal, occurring usually in a host with decreased immunity. The agents are ubiquitous fungi belonging to the Mucoraceae family, an ordinary saprophyte becoming pathogenous in patients with a severe disease (malignant hemopathy, diabetes) or treated by immunosuppressive drugs. Pulmonary localizations remained exceptional (128 cases found in the literature). The observations reported draws its originality from: -- the etiological circumstances: an aged patient with no hemopathy or diabetes, without immunosuppressive treatment but undergoing a prolonged antibiotic therapy; -- the clinical signs: discovery on X-ray of excavated infiltrates in a background of a severe infection with a very poor physical condition; -- the diagnosis criteria with the demonstration of the responsible mucor in the sputum, the endobronchial aspiration and transparietal puncture; -- the great efficiency of Amphotericin B at rather small doses. A review of the literature underlines the exceptional character of the cure.

Aged↗
PubMed1979

[Pulmonary allescheriosis (author's transl)].

In a patient properly treated for a previous cavitary tuberculosis, we had the surprise, after hemoptyses, to find a sleigh-bell shaped picture suggesting an intra-cavitary aspergilloma with a very special mycosis with Allescheria Boydii. Proof was provided by the presence of the fungus in direct examination and in culture in bronchial secretions. Surgical exeresis did not cure the patient and a secondary recurrence appeared on which antifungal drugs were ineffective. Antigens were made from the strain. They are used for immunoprecipitations tests. Only the patient's serum is positive; 82 serum test (18 concerned patients with visceral mycosis of farmer's lung disease) remained negative. Twenty two observations or pulmonary allescheriosis were recorded in the world. These figures are certainly below the truth. Three practical consequences can be drawn: --for an intra-cavitary mycetoma, with negative anti-aspergillus precipitins, such a disease must be kept in mind and the fungus looked for in bronchial secretions and specific immuno-precipitation test done; --any mycotic growth must be systematically cultured to determine the type of fungus; --for therapy, if diagnosis was made before the intervention, an antifungal treatment either local or general must be associated to the surgical treatment (contrary to aspergilloma treatment).

Aged↗
PubMed1978

[Two surveys on farmer's lung disease and bird breeder's disease in the Pyrenees region].

Two different surveys, one strictly epidemiological in rural areas, the other retrospective and within hospitals, led to a better knowledge of the setting of the FLD and BBD in South Pyrenees region. In the country, more than 12% of patients had specific precipitins, 6% had either one or both diseases; women had anti-aviary precipitins more frequently than men. The retrospective hospital survey yielded 456 cases of patients admitted or consulting revealing numerous correlations between the different clinical, radiological and functional syndromes on the one hand and the serological positivity on the other. Serological diagnosis was most useful, as a wide variety of antigenic extracts was used (actinomycetes thermophiles, mouldy hay, bird droppings), mixed sensitizing was extremely frequent. The widely found positivity towards avian antigens seems specific to the South Pyrenees region.

Adult↗