Biomedical subjects

J Pacyńska

Publications and source records attributed to J Pacyńska.

12 recordsLinked to original sources

PubMed1992

HLA-DR antigens in children with mumps meningitis.

The frequency of HLA-DR antigens was studied in 54 patients with mumps meningitis, and in two control groups. The first control group comprised 333 randomly chosen subjects while the second group was composed of 46 subjects who have passed mumps without meningitis. The DR5 antigen was more frequent in patients than in the second control group with relative risk of 2.4 and significance at the level of p < 0.05. The p value became insignificant after the correction for the number of antigens investigated.

Child↗

PubMed1992

HLA-A, B, C, and DR gene and haplotype frequencies in 600 poles by a maximum likelihood method of gene counting.

A population sample of 600 healthy, unrelated persons was used for estimating HLA-A, B, C and DR antigen, gene and haplotype frequencies. The Polish population is characterized by a high value of HLA-A10, B13, B27, DR1 and DR5 gene frequencies. Strong gametic associations between genes A1 and B8, A3 and B7, as well as between B8 and DR3, and B7 and DR2, typical for many European populations, are also present in the Polish population.

Adult↗

PubMed1990

[Hodgkin's disease and non-Hodgkin's lymphoma in 2 sisters].

For the first time in the Polish medical literature an appearance is presented of malignant lymphogranulomatosis and of a non-Hodgkin lymphoma in two sisters. A discussion on the etiology of the condition is presented on the ground of the cytogenic studies and tissue compatibilities antigens as well as of the literature of the subject. Genetic background of the two different diseases in two sisters is stressed.

Adult↗

PubMed1989

Blood transfusions and the development of cytotoxic antibodies in dialyzed patients.

In our work we investigated factors which can influence the alloimmunization and especially the ranges of cytotoxic antibodies that develop in patients on dialysis awaiting their first graft. Up to 15 liters of administered blood the proportion of immunized patients is rather stabile, not exceeding 50%. After further transfusions the percentage of immunized patients is growing rapidly reaching about 85%. Hyperimmunization, marked by cytotoxic antibodies with more than 80% panel reactivity is significantly more frequent in patients who obtained 15 and more liters of blood. In females the hyperimmunization is about 4 times more frequent than in males.

Antibodies↗

PubMed1989

Association of HLA-DR antigens with the development of cytotoxic antibodies in patients on dialysis.

Association between DR antigens and the occurrence of cytotoxic alloantibodies was studied in 251 patients on dialysis. Patients awaiting their first kidney graft were DR typed, and periodically investigated for the presence of alloantibodies. According to the observed peak panel reactive antibodies (PRA) the patients were divided into 3 groups: A, non-sensitized, B, moderately sensitized, and C, highly sensitized. The antigen DR3 was more frequent in sensitized (groups B + C) than in non-sensitized (group A) patients. This difference was significant on the level of P = 0.003, (Pcorr = 0.02). The antigen DR2 was more frequent in highly sensitized (group C) than in moderately sensitized (group B) patients with P = 0.002, not significant after correction for the number of investigated antigens.

Cytotoxicity, Immunologic↗

PubMed1988

HLA antigens and the antibody response after vaccination to hepatitis B.

The aim of our work was the search for immunogenetic factors that influence the antibody response to HBs antigen. We analyzed the HLA-A, -B, and -DR antigen frequencies in 19 seropositive to HBs and 28 seronegative to HBs healthy persons finding an elevated frequency of B5 in the seropositive group (p value 0.037). After vaccination with Hevac B Pasteur vaccine of the seronegative persons, the low antibody response was associated with B13 (p value 0.041). An association between local side reactions to the vaccine and HLA A3 and B35 were also found (p values 0.042 and 0.022 respectively). The presented p values are not significant after correction for the number of antigens tested and for this reason our findings require confirmation in an independent study.

Adult↗

PubMed1976