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Biomedical subjects

J Paillas

Publications and source records attributed to J Paillas.

At least 19 recordsLinked to original sources
PubMed1978

Acute experimental poisoning by diethylene glycol: acid base balance and histological data in male rats.

Acute intoxication by diethylene glycol (LD 50) in male rats is associated with a severe metabolic acidosis which is significantly decreased by intraperitoneal (IP) hydration or IP alkalinization and eliminated by IP ethanol. Tubular necrosis and deposit of calcium oxalate crkystals constitute the histological renal lesions in 50% of rats given diethylene glycol with or without IP hydration. Groups with massive IP alkalinization and/or IP ethanol do not present any renal lesion. It could be inferred that diethylene glycol has the same metabolic pathway as ethylene glycol and the treatment of acute intoxication by diethylene glycol should be the same as that of acute poisoning by ethylene glycol.

Acid-Base Imbalance↗
PubMed1976

[Intestinal lesions induced by radiotherapy of malignant pelvic tumors. Apropos of 2 cases].

Intestinal lesions after radiotherapy for pelvic malignant tumours are of two types: ulcerative colitis with stenosis and hemorrhage sometimes sevre and repeated, and ileal involvement with focal ischemic lesions and malabsorption responsible for nutritional disorders. It is difficult to distinguish them from a recurrence of the tumour in spite of endoscopy, arteriography and biopsy. The course in 3 stages is of great value in diagnosis. A reduction in the frequency of such complications may be hoped for by assessment and exclusion of predisposing factors, by strict observance of therapeutic rules. They are serious owing to the marked irreversible conjunctivo-vascular changes and the fragility of the irradiated tissues during operation.

Adult↗
PubMed1975

[Bone, joint, spinal and pelvic-spinal localizations of sarcoidosis (apropos of a case)].

Authors report on one case of particularly flourishing and evolutive sarcoidosis that conditioned numerous manifestations among which stand out lesions interesting one hip and one sacro-iliac articulation and also extensive and destructive bone lesions. This case is for them an opportunity for recalling the major facts related with bone lesions and articular manifestations of sarcoidosis and for calling attention on the spinal and pelvic-spinal involvements. The latter, when signs of bone lysis exist, are evocative of a neoplasm. More often, spondylodiscitis, coexisting sometimes with spindle-like paravertebral pictures, let think of tuberculosis. Confusion would be unavoidable if such facts, in spite of their rareness, were not better known.

Adult↗
PubMedDate not supplied

[Liquid cholesterol crystals, physical substrate of atheroma].

The study of the atheromatous arterial walls has been carried out on fresh specimens by frozen sections and polarization examination. Thus, it has been proven that the first deposits of cholesterol take place in the intima under the form of liquid crystals. These are very susceptible to temperature variations. They turn to liquid globules above 40 degree centigrad and partially reappear under the action of the cold.

Arteriosclerosis↗