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J Papillon

Publications and source records attributed to J Papillon.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Endocavitary irradiation in the conservative treatment of adenocarcinoma of the low rectum.

Early T1 and small T2 low rectal cancers may be controlled by endocavitary irradiation using the 50 kV Philips machine. The ambulatory treatment performed in the out-patient department consists of 4 applications within 6 weeks. Iridium-192 implant performed under local anesthesia is useful in many cases to give a booster dose to the tumor bed. In a series of 312 patients followed for greater than 5 years, the rates of local and nodal failure were 4.5% and 3.8%, respectively. The rate of death from cancer was 7.7%. After local excision endocavitary irradiation may be used as adjuvant therapy but it is safer to combine external beam and endocavitary irradiation. In the particular case of very poor risk patients with T2 or T3 tumors of the lower third of the rectum, a short course of external beam irradiation (30 Gy within 12 days) followed 2 months later by endocavitary irradiation may be a reliable procedure to prevent permanent colostomy in cases selected according to the patient's condition and the features of the residual disease. Of 67 patients followed for greater than 5 years, 3 patients died of distant metastasis and 5 patients died of local failures. These data, based on close collaboration with surgeons, suggest a reappraisal of the role of radiation therapy in the conservative management of rectal cancer.

Adenocarcinoma↗
PubMedDate not supplied

Role of pre-operative irradiation for anal preservation in cancer of the low rectum.

Since 1979, 157 patients with T2, T3, or T4 cancer of the lower rectum have been treated by a short course of irradiation, 30 Gy within 12 days by cobalt 60 using 120 degrees arc rotation on a sacral field, followed by a 2-month rest before surgery. The operative specimens were tumor-free in 13% of patients, Dukes' A in 40% of patients, Dukes' B in 22% of patients, and Dukes' C in 25% of patients. Three (1.9%) patients died postoperatively. At 3 years (107 patients) and 5 years (74 patients) the rates of death of local failure were 7.5% and 9.5%, respectively. The 3-year and 5-year disease-free survival were 71% and 58%. Since 1983, the surgeons took advantage of the tumor regression to carry out sphincter-saving operation in 67 patients with T2, T3, and T4 tumors of the lower third of the rectum. The proportion of patients treated by restorative surgery instead of abdominoperineal resection has grown significantly during the past 4 years, from 22% to 71%. Diverting colostomy was performed in 10 patients. Anastomotic leakages were observed in 7 patients. Of 31 patients who underwent low anterior resection and were followed 3 to 7 years (mean 4.5 years), 5 patients died of distant metastasis and 3 patients are alive after segmental hepatectomy. One patient had local recurrence which was controlled by abdominoperineal resection. The rate of 3-year disease-free survival was 77%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMedDate not supplied

[Postoperative radiotherapy of hemispheric glioma in the adult. A propos of 134 cases].

We are dealing here with a series of 134 hemispheric gliomas of the adult subject submitted to irradiation after surgical exeresis. The 2 years survival rate reaches 51 p. 100 for stage I and II astrocytomas (15/29) and 3,3 p. 100 for glioblastomas (30/91), the I year survival rate for the latter ones reaching 33 p. 100. The analytic study of medical literature lets appear that if roentgentherapy remains controverted in the case of stage I and II astrocytomas, it is recognized as useful, by all the authors, in the glioblastomas. Modalities and technique of the irradiation are object of an analytic study. Authors are favourable to post-operative irradiation stage I and II astrocytomas exhibiting pejorative features (focalized 6.000 to 6.500 rads) and to systematic post-operative irradiation in the glioblastomas over extended fields, either spreaded on irradiation (6.000 rads) or concentrated irradiation (two series of 1.800 rads). This latter technique has provided identical results as the spreaded on irradiation and represents a less heavy procedure. Mention is made of roentgentherapy in the supratentorial ependymomas (3 cases) and in the oligodendrogliomas (6 cases), followed by an analytic study of the complications consecutive to roentgentherapy of the encephalic tumors.

Astrocytoma↗