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Biomedical subjects

J Patricio

Publications and source records attributed to J Patricio.

15 recordsLinked to original sources
PubMed1980

[Free omental autografts revascularized by microsurgery (author's transl)].

The greater omentum is good plastic material and supplies richly vascularized connective tissue for transplants. Some superficial and deep lesions of the soft tissues require extensive excision, and in favorable cases it is possible to use the greater omentum pedicled as described by Kiricuta. Two such cases are reported. In other cases a free transplant of omentum revascularized by microsurgical methods has to be used. This procedure was employed in ten patients and allowed repair of lesions with wide or deep loss of tissue under excellent conditions. An intermediate saphenous graft was necessary in one case. A dermoepidermal graft was applied at the same time in order to obtain results more rapidly. Progress made in microsurgical techniques has allowed omentum revascularization to be carried out under much safer conditions and this procedure should be employed more frequently.

Adolescent↗
PubMed1978

[The gastro-intestinal effects of portal hypertension. Role of highly selective vagotomy. Experimental study in the rat (author's transl)].

Portal hypertension was obtained by portal ligature in the rat by an original procedure. Hemodynamic and pathological studies were performed at the end of the 4th postoperative month. Portal hypertension causes macroscopic and histological lesions in particular in the stomach and small intestine. The lesions observed were superficial desquamation, interstitial oedema, submucosal fibrosis, ulcers, and superficial or total necrosis of the intestine. Splenic fibrosis with congestion of the medullary sinuses is usual. A collateral circulation towards the liver and caval system develops rapidly. We never observed oesophageal varices. The main cause of splanchnic modifications was vascular stasis to which should perhaps be added humoral changes. Highly selective vagotomy does not protect the splanchnic area against lesions induced by portal ligature.

Animals↗
PubMed1977

[Effects of stress and highly selective vagotomy on mast cells in the wall of the rat stomach (author's transl)].

Quantitative changes in the gastric mast cells in ulcer diathesis and especially in the development of acute ulceration have already been studied. Qualitative changes may be asse-sed by Alcian Safranin blue stain which permits one to distinguish two sub groups: the blue mast cells and the red mast cells, which alone undergo degranulation. This report describes the modifications in number and aspect of the mast cells of the stomach of the white rat after stress due to restraint at variable intervals after highly selective vagotomy. The density of the mast cells and their appearance depend partly on vagal nerve supply. After highly selective vagotomy, their density increases while the initially unbalanced proportion of red and blue mast cells becomes normal in the long term. After stress, there is a reduction in the number of mast cells and, above all, disappearance of the red forms whether the rats are vagotomised or not. This study takes into consideration multifactorial problems which intervene in the etiology of stress ulcers and the necessity of continuing the study of the consequences of vagotomy.

Animals↗
PubMedDate not supplied

[Supra-selective vagotomy in the rat. A new experimental model. Preliminary results].

An original experimental model of highly selective vagotomy in the rat is proposed. The operative technique by microsurgery is described. The mechanical consequences of vagotomy are studied immediately and some time after the operation. Radio-cinematographic and E.M.G. studies, carried out, confirm the selective character of this vagotomy. The mildness of the symptoms observed at some time after the operation and the prevention of restraint ulcers by highly selective vagotomy are emphasized.

Animals↗
PubMedDate not supplied

[Reconstruction of the urethra by free jejunal graft].

Reconstruction of the penis using a free jejunum transplant with microsurgery revascularization was developed initially with an animal model. The technique was found to be successful in the dog and was applied in a 17-year-old patient. The main advantages of the technique are to permit mucomucosal anastomosis between the urethra and the jejunal transplant thus avoiding stenosis. The major disadvantages are the required laparotomy and microsurgery procedures. Indications are exceptional and result from major tissue loss due to trauma or tumoural development and/or in certain cases of transsexualism. The technique allows a better quality of life without exposure to the many complications described in the literature for other techniques.

Adolescent↗