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Biomedical subjects

J Patterson

Publications and source records attributed to J Patterson.

At least 163 records · Page 9Linked to original sources
PubMed1979

Neisseria meningitidis bacteremia in association with deficiency of the sixth component of complement.

The serum of a 26-year-old black man with a recent episode of meningococcemia complicated by meningitis and arthritis was found to lack hemolytic complement activity. The sixth component of complement was not detected by functional or immunochemical assays whereas other components were normal by hemolytic assay. His fresh acute-phase serum lacked complement-mediated bactericidal activity against the homologous strain of Neisseria meningitidis, but the addition of fresh normal serum or purified C6 restored bactericidal activity as well as hemolytic activity. The absence of C6 activity could not be accounted for on the basis of an inhibitor. Opsonization and chemotaxis functioned normally. Histocompatibility typing of family members did not demonstrate evidence for genetic linkage of C6 deficiency with the major histocompatibility loci. This report represents the first published case of C6 deficiency associated with bacteremic Neisseria infections in which antimeningococcal bactericidal antibodies have been definitively demonstrated against the homologous strain in the acute phase of the illness.

Adult↗
PubMed1979

A pragmatic approach to mental health aftercare and partial hospitalization.

Over recent years, there has been increased attention to providing viable community-based alternatives to inpatient psychiatric care. Although there is increased demand for aftercare or daycare social/psychological community treatment, funding sources also mandate more clearcut and precise demonstrations of therapeutic and program effectiveness. This paper describes a pragmatic new approach to daycare for the emotionally disturbed. The central aspects of this approach are: the behavioral identification of clearcut psychosocial treatment goals, contractual negotiation of treatment plans, a skill remediation approach to treatment and objective evaluation of client improvement. By adopting practical and individually-tailored treatment goals and modalities, and by incorporating objective evaluative criteria into a daycare program's treatment components, it is possible to more accurately assess client improvement.

Aftercare↗
PubMed1979

Objective evaluation and prediction of client improvement in mental health aftercare.

External funding sources and review boards appropriately are mandating more objective, clear-cut demonstrations of mental health program effectiveness. Mental health adult aftercare programs, traditionally characterized by globally-defined, imprecise goal and outcome measurement, can be objectively, empirically evaluated. The current paper illustrates how structured ratings and observations can be used feasibly to yield quantified "hard data" on client improvement and program effectiveness. The paper also presents the results of a program evaluation research study which indicate that while psychosocial history variables predict initial client appearance in aftercare, program participation-involvement behavior (and not psychosocial history) predict client improvement. Implications of these finds and the need for objective approaches to aftercare program evaluation are discussed.

Adult↗
PubMed1979

Studies on the competition of polyene antibiotics for sterols.

The fractional change in the corrected fluorescence of pimaricin or filipin in the presence of a limiting amount of sterol and a competing polyene antibiotic has been used to estimate the relative affinity of amphotericin B, nystatin, filipin, and pimaricin for stigmasterol and for cholesterol. The relative affinities for cholesterol were filipin greater than amphotericin B greater than pimaricin greater than nystatin, while the relative affinities for stigmasterol were filipin greater than pimaricin greater than amphotericin B greater than nystatin. The data indicate that pimaricin and filipin can both interact simultaneously with about 30% of the cholesterol or stigmasterol. However, the stoichiometry of filipin and pimaricin alone for cholesterol and for stigmasterol in dilute aqueous solutions is 1 : 1. In the experiments which indicated both pimaricin and filipin interact with the same sterol molecule changes in corrected fluorescence and the absorbance spectra were monitored; and these criteria indicated that both pimaricin and filipin had interacted with the sterols. Light-scattering measurements indicate large aggregates were not formed. Although the data shows in dilute aqueous solutions the stoichiometry of filipin and/or pimaricin for sterols is 1 : 1, in more complex solutions, other combinations or interactions are indicated especially for pimaricin.

Amphotericin B↗
PubMed1978

Drug therapy reviews: dietary fiber and fiber supplements in the therapy of gastrointestinal disorders.

Dietary fiber and fiber supplements are reviewed, with particular emphasis on their sources, composition and properties; physiological actions on gastrointestinal functions; and uses in gastrointestinal disease states (functional bowel disease, diverticular disease and other conditions). Adverse effects and contraindications, and the hypothesis of diet's effect on colon cancer also are discussed. Dietary fiber supplements may relieve symptoms of constipation, spastic colon, and diverticular disease; in the two latter disorders, colonic pressure relationships are altered. It is concluded that current evidence does not support other therapeutic uses for dietary fiber sonstituents, except possibly in patients with anal fissures and hemorrhoids, which can be helped by the passage of a softer stool.

Cellulose↗
PubMed1977

The problem of radiation dosage in the measurement of skin blood flow by xenon-133.

The skin dose arising from the use of xenon-133 in the measurement of skin blood flow has been calculated for several situations. The results indicate the importance of prior assessment of radiation dose in any technique involving the use of radionuclides. Cases where particular care must be taken have been indicated and practical methods of reducing the dose are suggested.

Humans↗
PubMed1977

Teaching assertive skills to a passive homosexual adolescent: an illustrative case study.

Social skills training was used to alter the socially inappropriate and ineffectual behavior of a 17-year old homosexual male. Target behaviors selected for treatment were the subject's effeminate mannerisms and lack of assertiveness in conflict situations, especially those involving other persons making derisive comments to him. A multiple baseline design was used to increase the patient's (a) eye contact, (b) rate of making appropriate requests for behavior change in others, and (c) general level of assertive affect. Six training and six generalization role-played interpersonal scenes were used. Results indicated significant improvement on trained social skills components with generalization to nontrained scenes as well. Implications of these findings are discussed, particularly with respect to social skills and assertion training for effeminate homosexuals.

Adolescent↗
PubMed1977

Young children's Rod-and-Frame Test performance.

Research on children's performance on the Witkin Rod-and-frame Test has suggested that children rely heavily on contextual cues in perceiving verticality but that this reliance decreases with age. In the present study this developmental trend in children younger than those previously tested was studied. The effect on performance of the conventional practice of tilting subjects in a chair which rotates about a seat axis, thus displacing the head away from the stimulus, was also studied. After a short training session 14 boys and 11 girls, 4.70 to 10.95 yr. old, were given 12 trials of the standard test while tilted about a seat axis and, on another day, 12 trials while tilted about a head axis. Although the axis of tilt and the order of presentation were nonsignificant, data tended to confirm the existence of a developmental trend in young children. An alternate scoring procedure to investigate errors in the direction opposite frame-tilt indicated that the initial tilt of the rod relative to the frame significantly affects the accuracy of judgments of the vertical.

Age Factors↗