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Biomedical subjects

J Patti

Publications and source records attributed to J Patti.

15 recordsLinked to original sources
PubMed1993

Dislocation of the sternoclavicular joint. Evaluation using paraxial computed tomographic reconstruction.

Sternoclavicular dislocations are relatively infrequent, constituting less than 1% of somatic dislocations. Despite the fact that the sternoclavicular joint is the only articulation between the upper extremity and the axial skeleton, it possesses the least amount of osseous stability of any joint in the body. Sternoclavicular dislocations are generally divided into anterior and posterior disruptions, the former being the most common. An unusual case of an anterior dislocation of the sternoclavicular joint with a large superior component is described. It was found that coronal paraxial computed tomographic reconstruction of the joint was quite useful in evaluating this injury.

Accidental Falls↗
PubMed1990

Streetside support.

Five years ago a small group of employees (health professionals and others) from Saint Joseph's Hospital, Atlanta, volunteered to prepare a meal for the homeless at one of the city's shelters. The experience led to a group decision to volunteer time to provide basic healthcare to the homeless. This soon led to the hospital-based Mercy Mobile Health Project, which, with community involvement, eventually became the Atlanta Community Health Program for the Homeless. Although the Saint Joseph's Mercy Care Corporation sponsors the program, a number of public and private agencies and professional groups are involved. All strive to expand efforts to address the problems of the homeless, to break the cycle of homelessness, and to provide continuing healthcare services where necessary. The number of clinic sites has more than doubled, while patient encounters have quadrupled.

Catholicism↗
PubMed1980

Effect of triiodothyronine and reserpine on induction and growth of mammary tumors in rats by 3-methylcholanthrene.

This study was designed to investigate the effects of exogenous L-triiodothyronine (LT3) and reserpine administration on the induction and stimulation of 3-methylcholanthrene (3-MC) mammary tumors. Two hundred-fifty-eight 30-day-old virgin 100 gm Sprague Dawley rats were divided into eight groups. Groups I-IV received either reserpine, LT3, both, or saline 22 days after tumor induction with 3-MC. Groups V-VIII were pretreated with either reserpine, LT3, or both for 29 days prior to tumor induction, and treatment was continued after tumor induction in all except Group VII. All rats were observed for tumor growth and sacrificed at seven months. Reserpine administration resulted in a protective effect against tumor induction in all groups in which it was used, with the most striking effects observed in the pretreated groups. Early LT3 stimulation of tumor formation was reversed by simultaneous administration of reserpine. Prolonged administration was unnecessary when both agents were administered prior to 3-methylcholanthrene.

Animals↗
PubMed1978

The relationship of cholecystectomy and taurocholic acid feeding to bile composition and hepatocyte function in prairie dogs.

The prairie dog was used as a model for human gallstone formation. Stones formed in the gallbladder of all animals on a lithogenic diet. Hepatic bile was nonlithogenic, whereas gallbladder bile promoted cholesterol precipitation. Addition of taurocholate to the diet reduced the number of stones and lithogenicity. Cholecystectomy resulted in an increased bile flow and reduced secretion of cholesterol in the animals on a high cholesterol diet. Reduction of cholesterol and bile acid synthesis by negative feedback was demonstrated in isolated hepatocyte culture. The shift of bile salt production to chenodeoxycholates on a high cholesterol intake was demonstrated both in vivo and in vitro. A theory of gallstone formation is presented which hypothesizes a defect in hepatocyte storage of cholesterol rather than bile acid synthesis as the primary effect, relegating the problems to one of a disease of lipid metabolism.

Animals↗
PubMed1977

The effect of para-aminobenzoic acid and taurocholic acid feeding on human bile composition.

Seven patients were investigated after cholecystectomy and exploration of the common bile duct to determine bile composition and excretion rates. An initial depression of the major components of bile stabilized by the sixth postoperative day. Feeding of para-aminobenzoic acid and taurocholic acid to these patients demonstrated an increase in excretion of total bile acids, taurine and glycine conjugates, cholates and deoxycholates. Para-aminobenzoic acid in the doses used failed to block glycine conjugation. Preferential conjugation of bile acid with glycine is due to a deficient taurine pool and not a preferential metabolic pathway.

4-Aminobenzoic Acid↗
PubMed1975

Current status of heparin dissolution of gallstones. Experimental and clinical observations.

Investigation of the use of heparin in bile indicates that it has the ability to disperse suspended particles. Clinical experience using a heparinized saline flush in forty-three patients with retained gallstones demonstrated disappearance of the stones in thirty-one of the patients. On this basis we would recommend this treatment for further clinical trials in patients with retained common duct stones.

Cholelithiasis↗
PubMed1975

The effect of sodium benzoate and taurocholic acid feeding on human bile composition.

Four patients were fed sodium benzoate after stabilization following common bile duct exploration. Bile collections revealed no change in the output of glycine conjugated bile acids. Three patients had taurocholic acid added to the regimen after 3 days and demonstrated a significant increase in total and taurine conjugated bile acid output with marked reduction of the G/T ratio. These latter changes are similar to those produced by taurocholic acid feeding alone and therefore no benefit of the combination of drugs on bile salt excretion or conjugation ratio was demonstrated.

Benzoates↗