Mechanism of action of amantadine.
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Biomedical subjects
Publications and source records attributed to J Pearce.
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In the non-laying pullet and the cockerel it was observed that there was no significant variation in the activities of ATP citrate lyase and ;malic' enzyme whereas in the laying hen there was a significantly greater activity of both these enzymes. Parallel increases in liver lipid content in the laying hen were also observed. Three glycolytic enzymes, phosphofructokinase, fructose diphosphate aldolase and pyruvate kinase, did not exhibit any significant variation in enzyme activity with the onset of egg laying. These results are discussed in relation to the hormonal status of the birds and also the demands of egg production for lipid.
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Insulin induced hypoglycaemia produced migrainous symptoms in only two of 20 migraine sufferers and in none of a matched control group. The relationship of fasting and blood sugar levels to migraine attacks is discussed.
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Serum uric acid levels measured by the phosphotungstic sodium cyanide method have been estimated in 60 patients suffering from a cerebrovascular incident. Patients with diseases known to predispose to hyperuricaemia were excluded. Twenty-five per cent. of patients with acute strokes had hyperuricaemia, and this did not appear to be a transitory phenomenon. These findings suggest that hyperuricaemia may be one of the factors in the pathogenesis of atheroma.