Thirty-four cases of inflammatory muscle disease (21% from a collective of 160 inflammatory myopathies) were suitable for morphometric measurements. A statistical analysis of our data yields a perifascicular fiber atrophy (PA) in 50% of these cases. Morphometry was able to detect also cases with significant PA which were evaluated subjectively as normal. In dermatomyositis, the finding of a PA was more frequent than in other subgroups of inflammatory myopathies. There was also an accumulation of PA in patients with a paraneoplastic polymyositis. It could not be confirmed that PA occurs more frequent in dermatomyositis of children.

Adolescent↗

PubMedDate not supplied

Anomalies in perifascicular muscle fibers as an differential-diagnostic criterion. II. Perifascicular hypertrophies in primary myopathies.

In order to compare a group of patients with a polymyositis (PM) to a control group, 28 cases of primary myopathies were examined by morphometry with regard to differences between central and peripheral muscle fibers in muscle fascicles. A significant difference in favor of peripheral muscle fibers, i.e., a peripheral hypertrophy was found in 22 out 28 cases (significantly in 14 cases). Therefore, histometry is a valuable additional method for discrimination between PM and primary myopathies.

Adolescent↗

PubMedDate not supplied

Oxalate-induced encephalitic reactions to polyol-containing infusions during intensive care.

Fifteen of 5800 neuropathologically examined brains showed oxalosis with an intense inflammatory reaction comparable to ethylene glycol intoxication. All patients had received intensive care therapy with infusions of high amounts of xylitol, sorbitol, mannitol, or fructose, mostly together with glucose. The encephalitic reaction induced by calcium oxalate crystals was manifested by clinical symptoms of cerebral damage. A genetically fixed polyol intolerance is hypothesized to explain polyol-induced oxaloses in brain, kidney, and partly also in myocardium.

Adolescent↗

PubMedDate not supplied

[Neuropathology in the Third Reich].

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Adolescent↗