Biomedical subjects
Publications and source records attributed to J Pensabene.
Fourteen samples from eight brands of elastic-rubber bands used in orthodontics were tested for their nitrosamine content. The presence of N-nitrosodibutylamine and N-nitrosopiperidine was confirmed. The potential for nitrosamine formation from accelerating agents used for vulcanization and from other nitrosatable amines, which may be present in rubber exposed to salivary nitrite, justifies further investigations.
alpha-Tocopherol has been evaluated as a nitrite scavenger for the prevention of nitrosamine formation in a model system and under practical conditions. alpha-Tocopherol was found to react with nitrosating agents in both lipophilic and aqueous environments. The use of alpha-tocopherol was shown to inhibit aminopyrene-nitrite induced hepatotoxicity in rats and to reduce the amount of NDMA formed in cigarette smoke. Of primary interest is the finding of a significant reduction of NPYR formation in fried bacon. Nitrosamine inhibition was greater with alpha-tocopherol used in combination with sodium ascorbate than with sodium ascorbate alone.
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