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Biomedical subjects

J Perek

Publications and source records attributed to J Perek.

9 recordsLinked to original sources
PubMed1990

Acute hemodynamic and arrhythmogenic effects of high-dose intravenous salbutamol in patients with chronic left ventricular dysfunction.

The short-term hemodynamic and possible arrhythmogenic effects of intravenous salbutamol at a dose of 30 or 60 micrograms/min were evaluated in 14 patients with severe chronic left ventricular dysfunction using equilibrium radionuclide angiocardiography and electrocardiographic monitoring. Salbutamol infusions at a dose of 30 micrograms/min did not cause significant hemodynamic changes; however, at a dose of 60 micrograms/min there was a significant increase in stroke volume, cardiac output, and left ventricular ejection fraction. Heart rate increased significantly while systemic peripheral resistance decreased significantly. Two patients developed ventricular premature beats and another two supraventricular tachycardia, but none were associated with adverse consequences. Thus, high-dose intravenous salbutamol is effective and safe, and may be used in the acute management of patients with poor left ventricular function.

Adult↗
PubMed1985

Fatal aspiration pneumonia caused by an esophageal foreign body.

Esophageal foreign body accompanied by respiratory complications is a rare condition. A few cases have been reported, only two of them in adults. We describe the case of a 34-year-old mentally retarded patient who was hospitalized for aspiration pneumonia and died 48 hours after admission. At autopsy, the prominent finding was a 3 X 3-cm stone impacted into the upper esophagus and compressing the trachea from behind. The possibility of an esophageal foreign body should be included in the differential diagnosis of unexplained respiratory distress or aspiration pneumonia in adults.

Adult↗
PubMed1984

Hypophosphatemia accompanying blastic crisis in a patient with malignant lymphoma.

A patient with malignant lymphoma showed severe hypophosphatemia during a blastic crisis. x-Ray microprobe analysis of the cells at this stage revealed a high phosphorus content. Following treatment and a decline in the white cell count the serum phosphorus increased, whereas the cellular phosphorus decreased. The potential prognostic value of serum and cellular phosphorus determinations during the course of malignant disorders of the hematopoietic system is discussed.

Adult↗
PubMed1984

Cytoplasmic inclusions and X-ray microprobe analysis in a case of prolymphocytic leukemia.

A patient with prolymphocytic leukemia is described. The peripheral blood and bone-marrow cells contained nuclear pockets, bridges, and appendices, as well as cytoplasmic inclusions that were not membrane bound or connected with the endoplasmic reticulum. X-ray microanalysis of the cells showed them to contain large amounts of phosphorus, sulfur, chlorine, and calcium, as well as a smaller amount of sodium and magnesium in comparison with control lymphocytes. When compared with lymphocytes of a patient with chronic lymphocytic leukemia (CLL), the patient's cells showed higher amounts of magnesium, sulfur, and chlorine, while the sodium content was decreased. The usefulness of electron microscopy and X-ray microanalysis in the diagnosis of this type of leukemia is discussed.

Adult↗
PubMed1984

Transmission and scanning electron microscopy findings in 37 patients with monocytic leukemia.

The ultrastructural features of the monocytic blast cells of 37 patients with M4 and M5 types of leukemia were examined with transmission (TEM) and scanning (SEM) electron microscopes. The cells showed a large variety in nuclear size and shape, dependent on the stage of cell differentiation. Nuclear pockets, appendices and bridges were observed. The cytoplasm contained perinuclearly located fibrils, occasionally elongated mitochondria and Auer bodies. The surface ultrastructure of the cells was similar to that of healthy monocytes, but often numerous blebs were observed.

Adult↗
PubMed1983

Two types of intracytoplasmic inclusions in the cells of a patient with acute lymphoblastic leukemia.

A patient with acute lymphoblastic leukemia (ALL) with cells containing two types of cytoplasmic inclusions is described. The inclusions appeared as globular bodies containing electron dense material with homogeneous structure and as crystalloid formations confined in organelles with structure similar to that of the surrounding mitochondria. In distinction to other reports, these structures were not related to the endoplasmic reticulum. The possibility that some of them represented altered mitochondria is discussed.

Acute Disease↗