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Biomedical subjects

J Petersen

Publications and source records attributed to J Petersen.

At least 19 recordsLinked to original sources
PubMed1978

The radiological assessment of gastric acid output in chronic renal failure.

The presence of hypertrophied gastric and duodenal mucosa as seen in the barium meal examination has been widely accepted as indicating an increase in gastric acid content. The present study of 31 uraemic patients undergoing maintenance haemodialysis suggests that in the uraemic patient this is not the case. Nineteen showed hypertrophy of the gastric mucosa radiologically but only eight had an abnormal pattern of gastric secretion. Of the 12 patients with a normal gastric and duodenal mucosal pattern, four showed an increase in the acid output of the stomach. It is concluded that the radiologist should beware of equating hypertrophy of the gastric and duodenal mucosa with a high gastric acid output in the chronically uraemic patient.

Adult↗
PubMed1978

Penicillamine-induced polymyositis-dermatomyositis.

Two patients with classical rheumatoid arthritis developed myopathy during treatment with penicillamine. In both patients, electromyography and muscle biopsies were indicative of polymyositis. In one patient, muscle enzymes were not examined at the appropriate time; in the other patient muscle enzymes were raised. This latter patient also had a rash and, in the dermal epidermal junction of pathological skin, granular deposits of immunoglobulin and complement were found. The myopathy subsided in both patients after withdrawal of penicillamine.

Action Potentials↗
PubMed1977

Hemodynamics at rest and during exercise in 222 patients with coronary heart disease before and after aorto-coronary bypass surgery.

In 222 patients with coronary heart disease hemodynamics at rest and during exercise were measured before and after aortocoronary bypass surgery. A total of 552 grafts were constructed, i.e. an average of 2.47 grafts per patient. Only 10.8% of the patients had a 1-vessel-disease, 59.2% had a 3-vessel-disease. 10.8% of the patients were provided with one graft, 49.7% got 3 or 4 grafts. In 92.8% of the patients the r. desc. ant. was significantly stenosed, and in 94.2% this vessel has been provided with a graft. Preoperatively only 7 patients had no angina pectoris during exercise (bicycle ergometer in supine position, each load lasting 6 min), postoperatively 154 patients have been completely free of angina pectoris. The preoperative angina pectoris-free exercise tolerance was 27.4 +/- 27.4 W (means +/- SD), postoperatively it was 76.5 +/- 33.8 W. The largest increase of exercise tolerance was observed in patients with a 3-vessel-disease (208%). Preoperatively only 10.1% had normal values of pulmonary wedge pressure and cardiac output at rest and during exercise, postooperatively 51.5%. The postoperative normalization of hemodynamics depends on the number of vessels involved (1-vessel-disease 86%, 3-vessel-disease 39.8% normalization) and on the status of the left ventricle (without a previous transmural myocardial infarction 68.4%; with a previous myocardial infarction 41.0%). The effects of revascularization on myocardial ischemia can be evaluated by measurements of pulmonary wedge pressure and cardiac output at rest and during exercise.

Angina Pectoris↗
PubMed1977

[Riskfactors and coronary morphology in 218 patients with myocardial infarction under 40 years of age (author's transl)].

With 218 postinfarction patients under 40 years of age who all underwent coronary angiography, the question in priority is: Can myocardial infarction in young age be characterized by special constellation of risk factors and by specific coronary morphology? Compared with results from literature the risk factors hypertension and diabetes seem to be of less importance than in older patients, smoking on the other hand seems to be more significant: 90.5% of postinfarction patients under 40 years of age were smoking regularly. Coronary angiography proved a pre-domination of 1-vessel disease: 72% showed 1-vessel, 17.9% 2-vessel and 10.1% 3-vessel disease. These findings and those from literature show that the majority of patients with myocardial infarction in young age have the following characteristics: In connection with the risk factor smoking the sclerotic coronary vessel process is developing rapidly, very often at a single spot. Since no longterm gradual occlusion process occurs, no prolonged period of angina pectoris precedes the infarction. There is no time for the development of an adequate collateral circulation; it follows that the infarction is a large one. After the acute infarction there is no angina pectoris.

Adult↗
PubMed1977

[Relationship between coronary angiographic findings and exercise Ecg in patients without transmural myocardial infarction (author's transl)].

In 311 patients (269 men and 42 woman, 20 to 65 years old) without transmural myocardial infarction the results of exercise tests in supine position were compared with the results of coronary angiography. 1. Patients having ischemic ST-segment depression (greater than or equal to 0.1 mV) and angina pectoris during exercise (n = 108) showed a greater than or equal to 50% stenosis of at least one vessel in 86.1%. In men the number of a greater than or equal to 50% stenosis was significantly higher than in women (91.3 vs. 56.2%). In patients without digitalis agreement with coronary angiographic findings is higher than in patients with digitalis (92.7 vs. 79.2%). After excluding women, patients under digitalis and those with an intramural myocardial infarction, agreement was 96.8%. 2. In patients having ischemic ST-segment depression agreement was 30% and in those with angina pectoris 36.8%. 3. In patients having neither ischemic ST-segment depression nor angina pectoris during exercise up to a heart rate of 80% of the age-dependent heart rate limit a coronary angiogram without a greater than or equal to 50% stenosis was found in 87.6%. After excluding patients with an intramural myocardial infarction, women and patients under digitalis, agreement increased to 97.9%. 4. In patients having both ischemic ST-segment depression and angina pectoris during exercise a 2- or 3-vessel disease was more often found than in patients having either ischemic ST-segment depression or angina pectoris, or in those having neither ischemic ST-segment depression nor angina pectoris respectively (57.5% vs. 16.6, 8.9 and 1.9%). 5. The number of positive coronary angiograms, especially of 2- and 3-vessel disease, increases with the degree of an ischemic ST-segment depression and the reduction of exercise tolerance.

Adult↗