PubMed Health⌕ Search

Biomedical subjects

J Pickup

Publications and source records attributed to J Pickup.

17 recordsLinked to original sources
PubMed1995

Where sensors lead.

Explore the source record for details and available documents.

Biosensing Techniques↗
PubMed1993

Developing glucose sensors for in vivo use.

The potential uses for in vivo glucose sensors in patients with diabetes mellitus include an alarm for low blood-glucose concentrations, a continuous read-out of glucose levels and as part of a feedback-controlled insulin delivery system (artificial pancreas). Most experience has been with implanted amperometric enzyme electrodes, though sensors based on field-effect transistors (FETs) show promise for the future. Sensing responses at the subcutaneous site correlate with plasma-glucose values, but there are often problems of calibration and drift. Implantable glucose sensors are not therefore in routine clinical use. Non-invasive glucose sensing based on near-infrared spectroscopy is being actively investigated as an alternative strategy.

Biosensing Techniques↗
PubMed1989

Human insulin.

Explore the source record for details and available documents.

Diabetes Mellitus↗
PubMed1986

Human insulin.

Explore the source record for details and available documents.

Animals↗
PubMed1983

Changes in blood flow close to subcutaneous insulin injection sites in stable and brittle diabetics.

Photoelectric plethysmography (PPG) was used to investigate blood flow changes close to superficial subcutaneous injection sites. As a validation procedure, the PPG response to subcutaneous injection of a known hyperemic agent, prostaglandin E1 (10(-5) M), was shown to correlate strongly with subcutaneous blood flow changes estimated by the established technique of 133Xe washout. Changes in blood flow over the subcutaneous injection sites of insulin (Actrapid) and insulin diluent were measured by photoelectric plethysmography in six nondiabetics and in six stable and seven brittle insulin-dependent diabetics. In all subject groups, an acute increase in local blood flow was seen within 2 min of both insulin and diluent injections, probably caused by injection trauma. At diluent injection sites, this acute hyperemia faded rapidly, blood flow returning to preinjection levels within 15-20 min, and there was no further increase in blood flow in any of the subjects. Insulin injected into the nondiabetics and stable diabetics caused a pronounced increase in local blood flow, sustained for at least 60 min after injection. In the brittle diabetics, however, there was no prolonged local hyperemia, the response being significantly less than that seen in both the nondiabetics and the stable diabetics. Insulin-related hyperemia close to injection (or infusion) sites may be important in subcutaneous insulin absorption. Its near-absence in brittle diabetics may contribute to the impaired response to subcutaneous insulin characteristic of these patients.

Adult↗