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Biomedical subjects

J Pirschel

Publications and source records attributed to J Pirschel.

18 recordsLinked to original sources
PubMed1991

[Chemoembolization of primary liver cancer using epirubicin-lipiodol].

The double supply of the liver allows one to perform specific embolisation of liver carcinomas since these are mostly supplied arterially. According to their occlusion characteristics--central, peripheral, capillary--different embolising materials are suitable for tumour embolisation under varying conditions. Oily substances cause capillary occlusion and can be used in conjunction with chemotherapeutic agents. This study deals with the results from lipiodol-epirubicin embolisation in 25 patients with hepatocarcinomas and cholangiocarcinomas. In a three-and-a-half year follow-up period 16 of these 25 patients died, maximum survival time being 28.4 months. Survival varied from 9.2 to 28.4 months compared with a survival time of 2-8 months in untreated patients. In this case hypervascular tumours have a better prognosis than the rarer hypovascular tumours because of improved deposition and activity of the chemotherapeutic agent.

Adenoma, Bile Duct↗
PubMed1991

[Chemo-embolization of inoperable hepatocellular cancer. A surgical-radiologic therapy concept].

The dual blood supply of the liver allows embolization therapy of malignant liver tumors nearly complete supplied by arterial vessels. The last three years we treated 25 patients with hepatocellular carcinoma by transcatheter arterial chemotherapy using iodized oil and anticancer agents suspension. The survival rate of untreated patients ranges between 1.6 and 2.5 months. Five patients died within two weeks to 9.7 months following embolization. Twenty of these patients are alive with survival rates of 1 to 22.9 months following the procedure. Because of the low procedural morbidity, transcatheter embolization is superior to surgical dearterialization or systemic chemotherapy.

Antineoplastic Agents↗
PubMed1990

[Peri- and postoperative roentgen diagnosis following esophageal bypass operation].

Between 1981 and 1987, 53 of 102 patients with malignant diseases of the oesophagus underwent bypass surgery with gastric, colonic or jejunic interposition. To recognise the early or later complications, we used X-ray examination of the chest, water soluble contrast medium and barium meal, real-time sonography and CT. With these methods we found insufficiencies of anastomosis, stenosis, fistulae to the adjacent organs, necrosis, infections, erosions and ulcerations of the anastomosis, pleuropulmonary complications and metastases. Without of early complications were 30%, without of late complications only 8% of all patients.

Colon↗
PubMed1989

Transcranial Doppler study of intracranial circulatory arrest.

To investigate the hemodynamics of intracranial circulatory arrest, the authors correlated the findings of noninvasive transcranial Doppler ultrasonography (TCD) with those of transfemoral four-vessel angiography in 65 patients following brain death and intracranial circulatory arrest due to severe intracranial hypertension. The three TCD stages of intracranial circulatory arrest, which have been described previously, corresponded with different levels of extracerebral angiographic cessation of flow. With TCD progression from the first stage (oscillating flow) to the third stage (no flow), the level where the dye stopped descended caudad from subarachnoid to cervical levels. The study shows that, in progressing intracranial hypertension, arterial circulatory standstill within the cranial cavity develops in a distal-to-proximal direction. The basal cerebral arteries remain patent in the early stages of intracranial circulatory arrest. Experimental evidence from the literature, together with the findings of the present investigation, points to the capillary bed as the initial site of the flow obstruction in progressing intracranial hypertension.

Adolescent↗
PubMed1989

[Long-term results following aorto-femoral Y bypass. Doppler ultrasound pressure measurement, real-time ultrasound, CT and i.v. DSA].

Five to seven years after aortoiliac prosthetic reconstruction 29 patients were examined by sonography (Doppler and real-time), CT and intravenous DSA. Doppler-sonography showed findings due to occlusion, stenosis and severe arteriosclerotic changing. By DSA these changing could be shown and exactly localised. CT demonstrated marginal thrombosis of the bypass lumen, aneurysms and fine paravascular fibrosis. So Doppler-sonography and DSA both bring functional and morphological, real-time sonography and CT morphological informations. The methods are complementary.

Aged↗
PubMed1979

[Computer tomographic differential diagnosis of thyroid diseases with special reference to scintigraphic cold spots (author's transl)].

A high proportion of carcinomas of the thyroid produce scintigraphic cold spots, this finding therefore requires further investigation in order to prevent unnecessary thyroidectomies. In order to clarify the value of computer tomography in thyroid disease, 70 patients with scintigraphic cold spots, or equivocal thyroid scans, were submitted to computer tomography of the neck. The findings in the majority of these cases have been correlated with histological results.

Diagnosis, Differential↗
PubMed1979

[Improvement of oral cholecystography and cholangiography with ceruletid (author's transl)].

Following oral cholecystography in 100 patients, the conventional "fatty meal" was replaced by an intramuscular injection of Ceruletid in a dose of 0.4 microgram/kg body weight. The synthetic decapetide Ceruletid is a substance with a hormone-like effect on the gastro-intestinal tract. It contracts smooth muscle in the gut and stimulates secretion in the stomach and the exocrine pancreas. Compared with other substances producing contraction which are given orally, Ceruletid acts more quickly and more powerfully in producing contraction of the gall bladder muscle. In 86% of positive cholecystograms, this resulted in satisfactory demonstration of the bile duct, 66% better than for oral substances. Many abnormalities, particularly localised adenomyomatosis, can only be diagnosed after good contraction of the gall bladder. Side effects, such as nausea, dizziness and a feeling of heat were transitory. In three patients it led to vomiting. The rapid and certain effect of Ceruletid during oral cholecystography requires reassessment of the role of intravenous cholangiography in diagnosis. Particularly amongst out-patients, with a high proportion of normal gall bladders, it is possible to complete the examination in one stage by demonstrating the bile duct with Ceruletid.

Bile Ducts↗
PubMed1976

[Toxic megaileum. Relapse of ulcerative colitis in the ileum following colectomy].

A 19 year old male patient suffered from ulcerative colitis and was colectomized 5 1/2 years ago. He presented now with an acute illness, characterized by massive discharges from the ileostoma, fever, leucocytosis, meteroism, melaena and a tender abdomen. A severe ulcerative inflammation of the total ileum was found. A "toxic megaileum" developed. At an operation the ileum was opened and drained. The patient recoverd under treatment with prednisolone, salazosulfypyridine, parenteral nutrition and Vivasorb. It is suggested that in this case the severe ileitis was due to the same disease which led to the total colectomy 5 1/2 years ago: ulcerative colitis.

Acute Disease↗