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Biomedical subjects

J Pittman

Publications and source records attributed to J Pittman.

30 records · Page 2Linked to original sources
PubMed1976

Antineoplastic and biochemical properties of arylsulfonylhydrazones of 2-formylpyridine N-oxide.

The structural parameters necessary for the antineoplastic potency of a new class of anticancer agents, arylsulfonylhydrazones of 2-formylpyridine N-oxide, were examined in mice bearing Sarcoma 180 ascites cells. The findings indicated that (a) replacement of the pyridine ring with benzene, quinoline, or isoquinoline resulted in loss of activity (b) movement of the formylhydrazone side chain from the 2 to the 3 or 4 positions of the pyridine N-oxide produced inactive agents (c) the pyridine N-oxide function was essential for anticancer activity, except for 4-substituted derivatives which were active without the N-oxide group, (d) replacement of the SO2 group by CO resulted in complete loss of activity, and (e) a carbon atom could be inserted between the SO2 and aryl ring with retention of anticancer potency. One of the most active members of this series, 1-oxidopyridine-2-carboxaldehyde p-toluenesulfonylhdrazone, exhibited antineoplastic activity against a broad spectrum of transplanted tumors including Sarcoma 180, Hepatoma 129, Ehrlich carcinoma, leukemia L1210, and a subline of Sarcoma 180 resistant to alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones. This agent caused inhibition of thymidine-3H and uridine-3H incorporation into DNA and RNA, respectively, of Sarcoma 180 ascites cells; protein biosynthesis was relatively insensitive to the action of this compound.

Animals↗
PubMed1969

The cancer you view.

Explore the source record for details and available documents.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Obsessive-compulsive disorder and comorbid anxiety problems in a national anxiety screening sample.

Questionnaire data were obtained from 5867 participants attending a national anxiety screening program. These participants were selected from more than 15,000 respondents on the basis of never having received treatment for a mental health problem. A screening instrument was designed to assess five anxiety disorders (obsessive-compulsive disorder, posttraumatic stress disorder, social phobia, generalized anxiety disorder, and panic disorder). The present study focused on those participants meeting full or partial screening criteria for obsessive-compulsive disorder (n = 3212), with those not meeting criteria for obsessive-compulsive disorder (n = 2655) serving as a comparison group. Significant relationships were found between questionnaire scores on both interference with daily living, readiness for treatment, and the number of comorbid anxiety problems. These findings shed light on the extent to which undiagnosed and untreated persons with obsessional or compulsive symptoms, or both, are experiencing, as well as the factors that may lead them to seek formal psychiatric or psychological treatment.

Adult↗
PubMedDate not supplied

The construction and assessment of a statistical model for the prediction of protein assay data.

The focus of this work is the development of a statistical model for a bioinformatics database whose distinctive structure makes model assessment an interesting and challenging problem. The key components of the statistical methodology, including a fast approximation to the singular value decomposition and the use of adaptive spline modeling and tree-based methods, are described, and preliminary results are presented. These results are shown to compare favorably to selected results achieved using comparitive methods. An attempt to determine the predictive ability of the model through the use of cross-validation experiments is discussed. In conclusion a synopsis of the results of these experiments and their implications for the analysis of bioinformatic databases in general is presented.

Computational Biology↗
PubMedDate not supplied

Associations between dental treatment in the primary and permanent dentitions using insurance claims data.

PURPOSE: The purpose of this study was to assess the associations between dental treatment in the early primary dentition and later treatment in the primary and permanent teeth. METHODS: Delta Dental Plan of Michigan insurance claims data on 9,886 children who were born in 1990 and were covered by dental insurance from 1990-1998 were used. Risk ratios (RR), screening test measures of sensitivity (SN) and specificity (SP), and evidence-based dentistry research measures of Likelihood Ratio (LR) and Number Needed to Treat (NTT) were calculated. RESULTS: Primary anterior tooth treatment at ages 0-3 was weakly associated (RR = 1.43, 95% C.I. = 1.23, 1.65) with treatment of the permanent first molars at ages 6-8 and had SN, SP, LR, and NNT values of 7.4, 95.3, 1.57, and 12 respectively. Primary posterior tooth treatment at ages 4-8 was more strongly associated with future permanent first molar treatment with a RR of 2.44 (95% C.I. = 2.26, 2.64) and SN, SP, LR, and NNT values of 65.9, 61.7, 1.72, and 6. CONCLUSIONS: For this population, early childhood treatment in the primary anterior teeth was a weak predictor of future permanent first molar treatment. Primary posterior teeth treatment, while still not a strong predictor, was better than primary anterior teeth in predicting permanent tooth treatment. Caries treatment at ages 4-8 in the primary teeth was better than treatment at ages 0-3 in predicting permanent first molar treatment.

Age Factors↗