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Biomedical subjects

J Pless

Publications and source records attributed to J Pless.

At least 37 records · Page 2Linked to original sources
PubMed1988

Experience with microlymphaticovenous anastomoses for congenital and acquired lymphoedema.

Ten unselected, consecutive patients were operated upon for lymphoedema of a limb. In order to evaluate the effect of microlymphaticovenous anastomoses no conservative treatments were used concomitantly. Seven patients had some relief of symptoms postoperatively, while six patients had a decrease in limb circumference. Three patients with primary lymphoedema had no effect of this treatment. Lymphoscintigraphy is advocated as an aid to the selection of suitable cases for microsurgery. Our future indications for microlymphaticovenous surgery for lymphoedema will be limited to patients with secondary lymphoedema with a duration of less than five years. The disease will be diagnosed by clinical examination as well as by lymphoscintigraphy.

Adult↗
PubMed1986

Chemistry and pharmacology of SMS 201-995, a long-acting octapeptide analogue of somatostatin.

Starting from a hypothetical conformation of natural somatostatin and a knowledge of the minimal fragment needed for biological activity, a process of rational design and lead optimization has led to the potent, selective, and long-acting analogue SMS 201-995, (formula: see text) which selectively inhibits growth hormone secretion in several animal species for up to 6 h after subcutaneous application. In the rat, SMS inhibits GH, insulin, and glucagon 70, 3, and 23 times more potently than SRIF, resulting in GH/insulin and GH/glucagon selectivities of 20 and 3, respectively. The compound has been shown to inhibit growth of transplantable insulinomas in hamsters and to label selectively a subset of somatostatin receptors in the rat cortex. A radioactively labelled analogue has been used to visualize somatostatin receptors in a GRF-secreting human tumour. The stability and duration of action of SMS 201-995 after subcutaneous injection enable for the first time extended investigations of the clinical utility of somatostatin in various diseases.

Animals↗
PubMed1984

Giant ventral hernias and their repair.

A method is described for the reconstruction of the abdominal wall in cases of large ventral hernia, by employing the frontal leaf of the rectus fascia and free fascia transplant, combined with muscle transposition. The results of 14 operations have been satisfactory in 11 cases, over an average observation period of 28 months. The method is recommended for very large ventral hernias, particularly in patients suffering from pulmonary symptoms, where reduction of the abdominal volume is undesirable.

Abdominal Muscles↗
PubMed1983

A new method of skin graft adhesion.

An industrially produced fibrinogen-Aprotinin and thrombin-calcium chloride 'tissue glue', Tisseel, has been tested for skin grafting. The 'take' of the graft was successful in 92% after grafting with Tisseel, and in 83% without gluing. In difficult areas, such as over mobile muscle or close to skin folds, 88% of cases were successful with tissue gluing and 44% without.

Adolescent↗
PubMed1977

A method of repair for unilateral macroglossia. Case report.

A method is described for the operative correction of unilateral macroglossia. The method permits the tongue to be reconstructed so that it assumes a relatively normal size and shape. The scar is led out to the lateral border of the tongue so that the reconstructed tip retains sensation.

Female↗