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Biomedical subjects

J Portugal Alvarez

Publications and source records attributed to J Portugal Alvarez.

At least 19 recordsLinked to original sources

[Satellite manifestations of internal diseases].

AIMS: Define the concept of satellite manifestations (SM) and to determine the number and types of them that appear in the diseases of each one of the subspecialties of the Internal Medicine. METHODS: 290 diseases are reviewed in agreements of Internal Medicine and specialties books and in each one are described the types of SM that they present. RESULTS: The respiratory diseases are the group that more SM presents and the less one the neurological. The most frequent type of SM are dermatological. The diseases that have more variety of types of SM are the endocrinologicals. Analyzing the percentages of every type of SM in relation with the number of diseases of every group, the highest are the dermatological SM in cardiac diseases. CONCLUSIONS: The SM are a very frequent phenomenon in the current medical practice and express the holistic character of the disease. His knowledge is indispensable in the internal medicine and subspecialties, where they can suppose a help in the diagnoses, though a bad knowledge of his reality can mean the opposite.

Cardiovascular Diseases↗

[Cytomegalovirus diarrhea as a diagnostic index for AIDS].

We report a case of a male 49 years old, without clinical history, excepting rape in 1996, that was admitted to the Emergency Room of HGUGM because of diarrhea 6 months duration, plus fever (39 degrees C) in the last 2 months. He was diagnosed of infection by the Human Immunodeficiency Virus (HIV), with serum antigenemia (70 cells), and colonic biopsy positives for Cytomegalovirus, and a normal colonoscopy. Cytomegalovirus colitis is the major etiologic infectious agent in patients with AIDS-associated diarrhea, although it can be the diagnostic index for AIDS in a few cases.

AIDS-Related Opportunistic Infections↗

[The incidence of the antiphospholipid syndrome in the clinical and biological manifestations of systemic lupus erythematosus].

In the present investigation a study was made on the incidence of antiphospholipid syndrome (APS) on clinical and biological manifestations in a series or 32 patients (28 females and 4 males with a mean age of 25 years) diagnosed of SLE (ARA criteria) and APS (Harris criteria) compared with a group of 25 patients (19 females and 6 males with a mean age of 38 years) diagnosed of SLE without APS. This entails a selection from 124 patients diagnosed of SLE, and an incidence of 25.8% and 9.7% for ACA and LA, respectively. After a clinical protocol was filled, a complete immunological profile was obtained, with lymphocyte subsets, IL-2 receptor, coagulation study, isotype determination for anticardiolipin antibody (ACA), lupus anticoagulant (LA), serology for syphilis and imaging diagnostic techniques. Comparative results, with an statistic assessment, are shown in tables. It is concluded that SLE + APS population can be considered as definite for a peculiar SLE subtype.

Adult↗

[Comparative study between seric I pepsinogen and seric gastrin, in the differentiation of the different types and localizations of chronic gastritis].

The present work analyzes the serie levels of pepsinogen I (PG I) and gastrin in relation to the histopathological findings with the optical microscope (OM) and electron microscope (EM) of different gastric mucosa biopsies obtained through fibrogastroscopy. 45 patients were studied (19 men and 26 women) with an average age of 63 with different clinical diagnoses documented later by fibrogastroscopy (peptic ulcer, neoplasia etc.), whose previous consent, two biopsies were taken at an antrum level and two biopsies at a fundic-body area level, analyzed later by OM and EM. The anatomopathological criteria followed in order to classify the condition of the mucosa was Whitehead's classification. The PG I and gastrin determination was carried out with RIA against a control group of 25 healthy individuals. Our study allows us to conclude that the normal or high serie concentration of PG I reflects a functional integrity of the fundic-body area, and low levels imply the presence of atrophic chronic gastritis at a fundic-body level. Thus a low level of PG I is a reliable marker of the atrophic condition of the mucosa and it can be considered as a precancerous factor.

Adult↗

[Syringomyelic arthropathy].

8 cases of syringomyelic arthropathy which were detected in 6 patients of 13 afflicted of syringomyelia, are presented. The etiopathogenesis, clinical, radiological, and pathological data are commented on; and an eclectic mechanism which mixed the 3 theories admitted: neurotrophic, neurotraumatic, and neurovascular, is suggested. We found the incidence of arthropathy higher than that described in existing medical literature and concluded that it is necessary to perform wide administer the appropriate therapy.

Arthropathy, Neurogenic↗

[Duodenal ulcer disease. A controlled study of aggressiveness and other personality factors].

We study the aggressivity level and its direction in the context of personality, in 36 patients with DUD (23 males and 13 females). We employed 30 patients with chronic disease (15 men with COPD and 15 female with arthrosis) as control groups, in addition to the normal population. The purpose of this investigation is to determinate if suffering or chronicity could determinate psychopathological findings similar to those described in the literature about patients with DUD. The results point out that we can not consider a specific ulcerous personality, but a psychophysiological reaction or psychopathological alterations resulting from a somatic disease, on the other hand the autoaggressivity factor pulsion-inhibition, is the most reliable variable when compared with control groups (p less than 0.05-0.01).

Adult↗

Pharmacokinetics of cefoxitin administered by i.v. infusion to patients with a pleural effusion.

The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pleural fluid in all cases was 2-3 fold longer than from serum, which shows a difference between the kinetic elimination processes of the antibiotic from the two fluids. The slow elimination of cefoxitin from pleural fluid facilitates its accumulation in this compartment during a multiple dosage regimen.

Aged↗