Biomedical subjects

J Prazák

Publications and source records attributed to J Prazák.

At least 37 records · Page 2Linked to original sources

PubMed1989

[Duffy blood groups and HLA antigens in hereditary motor-sensory neuropathy].

The Duffa system (Fya Fyb) and HLA antigens were examined in 86 subjects (39 affected, 47 healthy) in 17 families with HMSN type I, II and III. They recorded the incidence of autosomal dominant as well as recessive (possibly sporadic) forms. In the autosomal dominant form of HMSN type I a close relationship was detected between genes coding the investigated disease and blood cell signs Fya and Fyb. Recombination was found only in 9.1% of the cases. Investigation HLA antigens revealed marked reduction of the B27 antigen in the investigated patients. A striking sign in families with the autosomal dominant form of HMSN type I was an identical haplotype of the majority of parents.

Blood Group Antigens↗

PubMed1989

Study of HLA antigens in patients with Hodgkin's disease.

This paper studies relations of 21 HLA antigens of the A and B loci to selected characteristics in a group of patients with Hodgkin's disease. The investigated characteristics are age, sex, histological patterns, clinical stage and symptomatology. The considered group consists of 68 patients, 37 males and 31 females aged from 19 to 66 years and from 26 to 63 yr, respectively. A comparison between antigen frequencies for patients and controls (301 unrelated blood donors) is carried out. The results confirm that there is no relation between HLA antigens and Hodgkin's disease. A significant increase of A11 is found for females under 40 yr. Certain HLA antigens show significant correlation neither with the patient age nor with clinical or histological stages. A significant increase of B5 is observed for 16 relapsed patients. For them, significant test characteristics are found in the presence of cross-reacting HLA-B5, B35.

Adult↗

PubMed1989

HLA antigens and bronchogenic carcinoma.

Twenty-one HLA-A and B antigens were determined in a study of 162 patients with lung cancer. Differences between antigen frequencies in cancer and control populations were determined by chi 2 analysis with Yates correction or Fisher's exact test. Cancer patients had a decreased frequency of the antigen HLA-B40 (pc = 0.003; relative risk = 0.21). In patients with differentiated types of the carcinoma and relatively better prognosis, decreased frequency of the antigen HLA-B40 was found (pc = 0.05; relative risk = 0.27). Our investigation was based on a thorough study of literary data.

Carcinoma, Bronchogenic↗

PubMed1989

[Relation of HLA antigens and the length of survival in patients with acute leukemia].

The authors examined and evaluated by statistical methods 80 patients with acute leukaemia (AL). The group comprised 56 myeloid (AML) and 24 lymphocytic (ALL) leukaemias. In AL and AML no significant relations with transplantation antigens were detected. In ALL an increased frequency of HLA-B5 was found which was statistically significant (Fischer's test pc = 0.046). In women, as compared with men, an increased frequency of antigens A28, B17 was found and a reduction of HLA-B35. The values were not statistically significant. The authors sought relationships between the presence or absence of some HLA antigens (A2, A3, A10, B12) and the survival period of the patients. The results were not unequivocal. The findings were evaluated with regard to data reported in the literature.

Acute Disease↗

PubMed1988