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Biomedical subjects

J Presl

Publications and source records attributed to J Presl.

At least 19 recordsLinked to original sources
PubMed1992

Development and distribution of the white blood cells within various structures of the human menstrual corpus luteum examined using an image analysis system.

PROBLEM: Emerging evidences suggest that immunoendocrine interactions play definitive roles during development and regression of the human menstrual corpus luteum (hmCL). We have studied the distribution of immune cells within individual structures of hmCL during various stages of its development. METHOD: Immunoperoxidase-stained ultra-thin frozen sections were evaluated using light microscopy fitted with an image analysis system. RESULTS: The results suggest that monocytes/macrophages and MHC class II positive cells are the most prominent immune cells within the hmCL throughout its whole lifespan. Both cell types are concentrated within the trabeculae. In addition, MHC class II positive cells are abundant also within the granulosa-luteal layer. T helper/inductor (Th/i) and T cytotoxic/suppressor (Tc/s) cells were detected only in minor amounts within the thecal trabeculae of mature tissue. CONCLUSIONS: Possible links between the occurrence and functional roles of the immune cells studied are discussed.

Antigens, CD↗
PubMed1992

[Dynamics of the distribution of lymphocyte subpopulations in the human menstrual corpus luteum].

Recent evidence suggests that immunoendocrine interactions play a definitive role during development and regression of the human menstrual corpus luteum (hmCL). We studied the distribution of immune cells within individual structures of hmCL during various stages of its development. Immunoperoxidase-stained ultra-thin frozen sections were evaluated, using light microscopy fitted with an image analysis system. The results suggest that monocytes/macrophages and MHC class II positive cells are the most prominent immune cells within the hmCL throughout its lifespan. Both cell types are concentrated within the trabeculae. In addition, MHC class II positive cells are abundant also within the granulosa-luteal layer. T helper/inductor (Th/i) and T cytotoxic/suppressor (Tc/s) cells were detected only in minor amounts within the thecal trabeculae of mature tissue. Possible links between the occurrence and functional roles of the immune cells studied are discussed.

Corpus Luteum↗
PubMed1992

[Gestrinone in the therapy of sterility due to endometriosis].

Thirty-two infertile women with laparoscopic diagnosis of asymptomatic pelvic endometriosis were treated with gestrinone 2.5 mg twice weekly for 6 months. Subsequently, a second-look laparoscopy was performed in all of them. All of the patients were followed for at least 12 months after the end of treatment, during which time they attempted to conceive. Ten (31.25%) from all 32 treated women became pregnant. The highest incidence of pregnancy was in the stage I (12.5%) and II (12.5%) (rAFS) of endometriosis, a half of them in stage III (6.25%) and no pregnancy was recorded in the stage IV found prior to the beginning of therapy. There was no statistically significant (chi 2-test) relationship between the reduction of laparoscopic findings (defined as a visual extermination or as a decrease in staging of endometriosis) and pregnancy. In 19 (59.4%) from 32 treated women the stage of endometriosis remained unchanged, in 9 (28.3%) it was reduced by one up to three stages and in 4 (12.5%) the endometriosis was visually eliminated. In no case the staging of endometriosis was worsened during therapy. Gestrinone was well tolerated. In no one of patients it was necessary to interrupt the treatment untimely.

Adult↗
PubMed1991

[Favorable effects of oral steroidal contraceptives].

In addition to preventing pregnancy which in the wider sense of the word implies prevention of all complications of gestation, incl. extrauterine pregnancy, the use of steroid contraceptives has a favourable effect on some other diseases which are not directly associated with gestation. The authors give an account of all diseases where the use of steroid contraceptives may act as a preventive factor as regards the incidence of these disease and/or their intensity. This action is frequently omitted in the professional and lay press. The authors also draw attention to the advantages of modern steroid contraceptives with a minimal dose of oestrogens and on gestagens of the third generation.

Contraceptives, Oral, Synthetic↗
PubMed1991

Cell-mediated and neural control of morphostasis.

Morphostasis refers to the maintenance of the differentiated state of tissues in an adult individual and it represents a basal event of homeostasis and the organism's existence. Most of the cells in the body are arrested in their differentiation at a certain point related to their optimal function. Evidence is rapidly accumulating on the general role of immunoglobulin-gene superfamily (IGSF) domains in the non-immune control of behavior of cells in various tissues. A novel 'tissue control system' (TCS) has been suggested, supporting the differentiation of tissue cells in an adult organism and functioning via the IGSF domains and cell-mediated control of morphostasis. We assume here that the morphostasis is established epigenetically during the early adaptive period. With its termination, coinciding with the attainment of an organism's immunocompetence, the combination of cell surface markers of the most mature cells in tissues are encoded in the TCS as the stop-signal (SS). This stage of tissue differentiation is maintained during further life: upon recognition of SS the committed TCS element does not stimulate further differentiation of the cell, i.e. it exhibits a stop-effect (SE). Each tissue-specific cell line has only one or no SE established depending on its presence or absence during development, respectively. The only way to escape an established SE and continue in differentiation is to change at least a portion of the SS. Hormones might act here directly, by conformation of their cell surface receptors recognized as a portion of SS, or indirectly, by influencing proteosynthesis of cell surface markers.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗