Biomedical subjects

J Prickaerts

Publications and source records attributed to J Prickaerts.

23 records · Page 2Linked to original sources

PubMed1996

Effects of myocardial infarction and captopril therapy on anxiety-related behaviors in the rat.

The angiotensin-converting enzyme inhibitor, captopril, is used in the treatment of heart failure after myocardial infarction. This study evaluated whether different behavioral parameters of anxiety are affected by captopril therapy after myocardial infarction in rats. Myocardial infarction was induced by ligation of the left coronary artery and captopril therapy was started after 3 weeks. After 2 weeks of captopril therapy, anxiety-related behaviors were successively measured in four different tests: open field, elevated plus maze, home cage emergence, and open field escape. Myocardial infarction and captopril therapy affected behavior in the home cage emergence test and open field escape test. On the basis of the data from the open field escape test, captopril therapy appeared to decrease anxiety in infarcted rats and increase anxiety in sham rats. Because myocardial infarction and captopril therapy did not affect anxiety-related behaviors in the open field and elevated plus maze tests, it is assumed that these interventions affect anxiety-related behaviors depending on the type of test. This was partially supported by correlation analysis, which suggested that the behavior of the rats in the different tests of anxiety may reflect different anxiety-related traits.

Angiotensin-Converting Enzyme Inhibitors↗

PubMed1995

Brain enzyme activities after intracerebroventricular injection of streptozotocin in rats receiving acetyl-L-carnitine.

Intracerebroventricular (i.c.v.) injection of streptozotocin has been introduced as a means to inhibit glucose utilization in the rat brain, and to induce changes in neurotransmitter systems and behavior which resemble those seen in Alzheimer's disease. In this study, enzyme activities previously investigated in Alzheimer's disease (peptidases, dehydrogenases and acetyltransferases) were measured in the septum and hippocampus of control and streptozotocin-treated rats. Streptozotocin-treated rats receiving acetyl-L-carnitine were also included in the experiments, to assess possible neuroprotective effects of this substance. All enzyme activities in the septum were affected by streptozotocin, with the exception of choline acetyltransferase activity. By contrast, choline acetyltransferase activity was the only enzyme activity affected in the hippocampus. The weight of the septum was reduced in streptozotocin-treated animals. These findings indicate that i.c.v. injection of streptozotocin causes septal damage and enzymatic changes that do not closely resemble those seen in Alzheimer's disease, which are more specific. Acetyl-L-carnitine partly prevented this damage, as reflected by an attenuation of the streptozotocin-induced decrease in hippocampal choline acetyltransferase activity. This finding indicates that streptozotocin-treated rats may be valuable to test possible neuroprotective effects of drugs.

Acetylcarnitine↗

PubMed1995

Spatial discrimination learning and choline acetyltransferase activity in streptozotocin-treated rats: effects of chronic treatment with acetyl-L-carnitine.

Treatment of rats with i.c.v. injected streptozotocin (STREP) may provide a relevant model of neurodegeneration that is induced by a decrease in the central metabolism of glucose. Acetyl-L-carnitine (ALCAR) enhances the utilization of alternative energy sources and by such a mechanism of action ALCAR could antagonize the effects of STREP treatment. In this study the effects of chronic treatment with ALCAR were evaluated on spatial discrimination learning in the Morris task and choline acetyltransferase (ChAT) activity of middle-aged STREP-treated rats. Chronic treatment with ALCAR attenuated both the STREP-induced impairment in spatial bias and the decrease in hippocampal ChAT activity. These findings indicate that ALCAR treatment has a neuroprotective effect, although further studies are needed to characterize the mechanism of action of ALCAR in this model.

Acetylcarnitine↗

PubMed1993

Absence of impairments in spatial and temporal discrimination learning in Lewis rats after chronic ethanol consumption.

Many studies reported that chronic ethanol consumption leads to cognitive dysfunction in rodents. It has been suggested that the effects of chronic ethanol consumption resemble those of aging because of the behavioral and neurochemical similarities between the two processes. The present study examined the effects of a chronic ethanol treatment (20% aqueous solution) in Lewis rats on performance in three different tasks: the Morris spatial navigation task, a cone-field task, and a temporal discrimination task. Although an age-related deficit was found in water escape learning, chronic ethanol consumption did not affect the performance of adult and old rats. The results of this experiment were, however, not conclusive. No differences between old control and ethanol-treated rats were found for spatial (cone-field task) and temporal discrimination learning. However, old ethanol-treated rats showed a transient tendency to perseverate in the temporal discrimination task. The present results are at variance with the generally found cognitive impairments after chronic ethanol consumption using aqueous solutions. It is suggested that the effects of ethanol could be related to strain of rat, task complexity, method of ethanol administering, and housing conditions and may explain the discrepancy between results.

Aging↗

PubMed1992

Reduced level of anxiety in adult Lewis rats after chronic ethanol consumption.

Many studies have shown that chronic ethanol consumption leads to a decline in learning and memory performance in rats and mice. However, other aspects of behavior have received less attention. Anxiety, for example, is known to be affected in alcoholics but has not been studied in animal models of ethanol consumption. In order to study the effects of chronic ethanol consumption on anxiety, twelve 3-month-old Lewis rats were given a 20% ethanol solution for 6 months as the only source of liquid, while a control group (n = 11) received tap water. Both groups were subjected to three different tests three weeks after cessation of treatment. Data analysis indicated that in all three tests the level of anxiety was reduced in the chronic ethanol-treated rats. Therefore, learning and memory measures, especially in aversively motivated tasks, may be confounded by differences in levels of anxiety between control and ethanol-treated rats.

Alcohol Drinking↗