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J Proctor

Publications and source records attributed to J Proctor.

34 records · Page 2Linked to original sources
PubMed1982

Delayed hypersensitivity testing for the prediction of postoperative complications.

One hundred and sixty-six patients undergoing elective major laparotomy were skin tested preoperatively with four common recall antigens in an attempt to correlate preoperative cell-mediated immune status with postoperative septic complications. Nineteen patients were anergic, 22 relatively anergic and the remaining 125 reacted to two or more of the antigens and were regarded as normally reactive. No significant differences in morbidity or mortality were found between patients who had depressed delayed cutaneous hypersensitivity reactions and those who reacted normally. We conclude that identification of those patients with depressed cell-mediated immunity preoperatively does not help in predicting postoperative problems.

Adult↗
PubMed1982

Estimating the effect of etching agents on plastic sections.

The effects on epoxy embedding media of certain etching procedures have been studied in two ways. Firstly the resin present in thick sections, before and after etching, was demonstrated by staining the plastic with Sudan Black B. Secondly the change in weight of plastic blocks after their exposure to etching procedures was measured. Methods involving halogens in acetone, alkoxides in ethanol or in methanol-benzene, and performic acid resulted in gross removal of plastic. Additionally, in keeping with the widespread belief that etching may increase permeability of plastic sections to stains, most of the etch methods studied, including organic solvents alone, did remove some plastic from the blocks.

Epoxy Resins↗
PubMed1982

A typical band-shaped calcific keratopathy with keratocyte changes.

The clinical features of a patient with atypical band keratopathy are described. Histochemical and electron probe analyses indicate that the granular deposits in Bowman's layer contain calcium and phosphate. An unusual feature in this patient was the presence of severe keratocyte degeneration; its possible role in the pathogenesis of this condition is discussed. Exfoliation of the calcified Bowman's layer appears to have been the basis for severe attacks of recurrent ocular pain.

Adult↗
PubMed1980

Stereological studies on chronic lymphocytic leukaemia and hairy cell leukaemia.

Using stereological techniques at the ultrastructural level, 7 quantitative parameters for 7 patients with hairy cell leukaemia, 27 patients with chronic lymphocytic leukaemia, and 8 normal individuals. These quantitative data show clear differences between normal lymphocytes, CLL cells and the abnormal cells of HCL. They also show that it may be possible to subdivide CLL into distinct groups on quantitative criteria.

Cell Nucleus↗
PubMed1978

A collision analysis of lymphoid cell aggregation.

We have obtained data on the frequency of aggregates of different size classes and on the maximum aggregate diameter of lymphoid cells subjected to aggregation in the laminar shear field of a Couette viscometer. Maximum aggregate diameter reached a plateau level during aggregation. This plateau is considered to be the result of a balance between the hydrodynamic shear forces tending to resist the formation of aggregates, and the adhesive forces of the aggregated cells tending to resist dissociation. Stepwise-increases in the shear rate produced aggregates of progressively smaller maximum diameter until the limiting (i.e. control equivalent) diameter was reached. Equations governing these stepwise changes in aggregate diameter were obtained by regression analysis, and an estimate of the force of dissociation (FD) was made from derived values of the critical shear rate. Thymocytes (FD=2.54 X 10(-6) N m-2/cell) were found to be more adhesive than lymphocytes (FD=2.05 X 10(-6) N m-2/cell), in agreement with current concepts. The observed data on aggregate frequency were seen to be of poor fit with a model of aggregation derived by collision analysis of the aggregation process. This led us to consider the possibility that all cells may not share the same probability of forming an adhesion. We thus derived further models of aggregation in which some fraction of the total cells was considered to have enhanced possibilities of a collision producing an adhesion. Of the models we considered, a 15% preferred fraction offered best agreement with the experimental observations. We therefore conclude that the populations of cells studied in this report are not 'homogenous' in that some cells are more adhesive than others. Alterations in the percentage of the preferred fraction of cells will lead to different aggregate-frequency indices. Such changes might be expected to occur during the initial stages of carcinoma development.

Animals↗
PubMed1978

Control of somite number in normal and amputated mutant mouse embryos: an experimental and a theoretical analysis.

A regulation is shown for size and number of serially repeated axial structures, the somites, in a mammalian embryo. The mammalian embryo is normally inaccessible to operation at post-implantation stages. This problem is resolved by the quantitative analysis of somite size, number and development in a recessive mutant of the mouse, amputated, whose axial length is greatly reduced. The effect of the gene simulates an experiment ablating part of the embryonic tissue available for somitic segmentation. Regulation occurs at the time when the somite is first formed, by control of the quantity of cells included in each new somite. A model is devised for the control of somitic segmentation which explains most of the features observed and which can be simulated on a computer.

Amputation, Surgical↗
PubMed1970

Autoimmunization with irradiated tumour cells in human malignant melanoma.

Thirteen patients have been immunized with their own irradiated melanoma cells on one or more occasions. Following these autografts tumour-specific cytotoxic antibodies were produced, the longest response lasting 14 days. This procedure had no apparent effect on the course of the disease in these patients.

Adult↗
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Humans↗