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J Pryjma

Publications and source records attributed to J Pryjma.

At least 91 records · Page 5Linked to original sources
PubMed1977

Influence of cobra venom (CoF) and pneumococcal S III capsular polysaccharide on immunologic humoral response and visceral distribution of antigens.

The immunologic response to sheep erythrocytes was compared in mice treated with Cobra venom (CoF) and with pneumococcal capsular antigen S III. Suppression of the immunologic response in both cases was attributed to the ability of both tested substances to activate the third component of complement. CoF and S III both changed the organ localization of labeled antigens capable of activating the complement system. No evidence for an alternative pathway by which S III could activate the complement system was found. On the basis of the literature data and experimental findings, the properties of CoF and S III were compared in the light of their ability to suppress the immunologic response.

Animals↗
PubMed1977

Feedback inhibition of IgM memory cells by high antigen dose.

The ability of high and low antigen doses (SRBC) to recruit IgM memory cells has been compared in several strains of mice. In intact animals priming with low doses was more efficient than priming with high doses. If, however, mice of different strains were X-irradiated two days after priming and repopulated, regardless of whether syngeneic or allogeneic splenocytes were used, they fell into two categories--those in which more memory cells were found after low antigen priming and those in which the reverse was true (Swiss mice). Two possible explanations are offered to explain these interstrain differences--antibody mediated suppression, and generation of suppressor T cells. Our data favor the latter, and we assume that suppressor T cells appear at different intervals after priming in different strains of mice, and that these cells are radioresistant.

Animals↗
PubMed1975

Prolonged C3 depletion by cobra venom factor in thymus-deprived mice and its implication for the role of C3 as an essential second signal for B-cell triggering.

Cobra venom factor (CoF) is a potent immunogen in intact mice, and its capacity to deplete C3 is neutralized by antibody. In thymus-deprived (T times B) mice antibody was not elicited; C3 depletion by CoF was prolonged, and subsequent injections were also effective. The effect of prolonged C3 depletion was examined on the antibody response to two T cell-independent immunogens, levan and SIII. The spleen PFC responses to levan were unaffected by C3 depletion or thymus deprivation; those to SIII were unaffected by thymus deprivation but were diminished (not abolished) by C3 depletion. It is argued that the capacity to activate C3 is neither sufficient nor necessary to cause an immunogen to be T cell-independent.

Animals↗