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Biomedical subjects

J Pulman

Publications and source records attributed to J Pulman.

5 recordsLinked to original sources
PubMed1984

Clomipramine treatment of repetitive behavior.

The paper describes an informal, open trial of the effect of clomipramine on 8 patients with repetitive behaviors which were not part of a classical obsessive-compulsive neurosis. Six chronic schizophrenics had obsessions, compulsions and rituals in addition to their schizophrenic symptoms. Four of the six showed reduction in the repetitive behavior with clomipramine. Two cases in which the target symptom and overall clinical picture had little in common with obsessive compulsive neurosis, are reported in detail. Both improved with clomipramine. It is suggested that clomipramine may be useful in the treatment of a broad range of psychiatric disorders characterized by repetitive mental or behavioural phenomena, but which do not fulfill criteria for obsessive-compulsive neurosis.

Adult↗
PubMed1983

Capgras syndrome in siblings.

The hallmark of the Capgras Syndrome is delusional misidentification of persons, objects or animals. It can occur in organic syndromes and in functional disorders. Hence there are adherents of organic as well as dynamic factors in the genesis of this disorder. The authors report the occurrence of the Capgras Syndrome in a brother and sister and elaborate on the interplay of both genetic and dynamic factors in the etiology.

Adult↗
PubMed1981

Effect of sleep deprivation on dopamine receptor function in normal subjects.

Twenty-four hours sleep deprivation significantly decreased the growth hormone response to the dopamine receptor agonist, apomorphine HCl, in five normal men (0.5 mg s.c.) and one woman (0.75 mg s.c.) but had no effect on basal or post-apomorphine prolactin concentrations. These results suggest that sleep deprivation decreases the sensitivity of certain central dopamine receptors. The relevance of this finding to the antidepressant effect of sleep deprivation is unclear.

Adult↗
PubMed1979

Effect of naloxone or levallorphan on serum prolactin concentrations and apomorphine-induced growth hormone secretion.

Naloxone HCl (0.8 mg intravenously; n=9) or levallorphan tartrate (0.25 mg subcutaneously; n=5) had no effect on basal prolactin or growth hormone secretion in normal men. Neither narcotic antagonist inhibited the growth hormone secretory response to apomorphine HCl (0.75 mg subcutaneously). These findings suggest that narcotic antagonists do not block dopamine receptors in the hypothalamic-pituitary axis in man and that if these agents have antischizophrenic properties then these are not mediated by dopamine receptor blockade.

Apomorphine↗