[Current problems in asthma therapy].
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Biomedical subjects
Publications and source records attributed to J Quäck.
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141 cases with malignant Non-Hodgkin-lymphomas are reported. The stage and results of radiological and/or cytostatic treatment as performed at the radiological clinic of the Kiel University have been related to the histological diagnosis according to the Kiel classification. Therewith, the differentiation by the pathologist between low-grade and high-grade malignancies is evidently clinically relevant.
In a joint retrospective study by 17 radiotherapy clinics in German-speaking countries the results of treatment of bronchial carcinoma after radiotherapy were analysed in 7503 cases. The age peak was between the 60th and 70th year. Squamous-cell carcinoma was the most frequent histological type, followed by anaplastic carcinoma, with adenocarcinoma being rare. There was a high proportion of histologically not clearly identified cases (27% in central and 35% in peripheral carcinomas). Survival rate at one year was 31% for central (3662 patients) and peripheral (961 patients) tumours, but only 2% at five years. Prognostically there was no difference between histological types and kind of radiotherapy or technique, but total dose affected survival rate. At a total dose of less than 5000 rd the survival rate at five years was minimal. The prognosis of combined surgical and radiotherapeutic measures was slightly better than with a radiotherapy alone, but results were unpredictable for the individual case. It is concluded that radiotherapy aiming at cure should be used in imoperable bronchial carcinoma if the tumour state and general condition of the patient appear to make a cure possible. But if this is not the case, radiotherapy should be used only palliatively, i.e. only to ameliorate symptoms.
Treatment's possibilities of the carcinoma of larynx are presented and we especially attract notice to require a right distribution of stages in conformity with the prescriptions from the U.I.C.C. Operation's methods and radiotherapeutic possibilities are indicated. Following the author's views, it would be made primary irradiations in the stages T1 and T2, while only after the operation it would be necessary to use a radiotherapy in the stages T3 and T4. The possibility of a preoperative irradiation in the advanced stage is taken up. The problem of the reappared tumor is discussed and it is made a transition to the possibilities of the chemotherapy. The possibilities of a fractionated synchronisation of the intraarterial therapy of the tumor and a possible polychemotherapy are discussed.
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