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Biomedical subjects

J R Boen

Publications and source records attributed to J R Boen.

8 recordsLinked to original sources
PubMed1992

Association between stimulated plasma C-peptide and age: the Wadena City Health Study.

OBJECTIVE: To assess age-related changes in stimulated plasma C-peptide in a population-based sample of adults. DESIGN: Cross-sectional study. SETTING: Wadena, Minnesota, a city of 4,699 residents (1980 census) in west central Minnesota, approximately 150 miles from Minneapolis/St. Paul. STUDY SUBJECTS: 344 non-diabetic subjects (NDDG standards) from a stratified random sample of the total adult population of Wadena, MN. The six-study strata were men and women from three age groups: young, 20-39 years of age; middle-aged, 40-59; and older, greater than 60 years of age. MEASUREMENTS: During a liquid meal of Ensure-Plus (Ensure-Plus challenge test; EPCT; Ross Laboratories), blood samples were taken for glucose, free fatty acids, creatinine, and C-peptide. Plasma C-peptide taken 90 minutes after the EPCT was used as a surrogate measure for insulin. Clinical tests included one-time samples for hemoglobin, glycosylated hemoglobin, plasma cholesterol, triglycerides, and lipoproteins. Physical measurements included height, weight, and blood pressure. Urine was assayed for C-peptide and creatinine. Assays of urine and plasma C-peptide used antibody M1221 (from Novo; Copenhagen, Denmark). MAIN RESULTS: No differences were observed for the relationship between age and C-peptide within each of the three age groups for men and the three age groups for women. However, the levels of plasma C-peptide for older men or women were statistically significantly higher than levels for the young age groups of the same sex; fasting plasma glucose also was higher for older groups of both sexes, and postmeal glucose was significantly higher for older women. There were decreases with age in urine C-peptide clearance for women and men; the decline for women was statistically significant. In multiple regression models for men alone and women alone, that controlled for age, post-meal plasma glucose best explained plasma C-peptide levels. For young men, plasma glucose alone provided the best prediction of plasma C-peptide levels; body mass index (BMI) and plasma glucose provided the best prediction for young women. For older men and both middle-aged and older women, a combination of urine C-peptide clearance and plasma glucose best predicted plasma C-peptide levels; for middle-aged men, BMI also contributed to the prediction. CONCLUSIONS: Secretion of insulin in response to an orally administered mixed meal is undiminished with age in non-diabetic adults.

Adult↗
PubMed1990

Population-based study of impaired glucose tolerance and type II diabetes in Wadena, Minnesota.

The Wadena City Health Study was undertaken to assess the nature of type II (non-insulin-dependent) diabetes and its relationship to aging. This article reports the study methodology and prevalence estimates for type II diabetes and impaired glucose tolerance (IGT) for the adult population of Wadena, Minnesota. The sampling frame for the study included all known diabetic individuals and all other residents based on a complete citywide census of residents greater than or equal to 20yr of age. A stratified random sample that included three stratifying factors (age [20-39, 40-59, greater than or equal to 60 yr], sex, and self-reported weekly use of any prescribed medication was drawn from the other residents). The study protocol required diet preparation and two full mornings of testing. Data collected included height, weight, and blood pressure measurements and both a personal interview and a medications questionnaire. A 75-g oral glucose tolerance test (OGTT) and a test with a standard liquid meal (Ensure-Plus challenge test [EPCT], Ross) were done on two mornings, with the order of testing randomly assigned. Clinical tests included one-time samples for hemoglobin, glycosylated hemoglobin, plasma cholesterol, triglycerides, and lipoproteins. Blood samples for glucose and creatinine assays were taken during the OGTT; blood samples for glucose, free fatty acid, creatinine, and C-peptide were taken during the EPCT. Urine collections were performed for both challenge tests and assayed for C-peptide and creatinine. Seventy-one percent of the known diabetic subjects, and 65% of the stratified random sample participated in the study.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

The effect of definitive irradiation on local control and disease free survival in breast cancer.

The prognostic factors important in determining local regional control or failures can be divided into two groups. The first, the intrinsic factors, relate to the initial inherent condition of the tumor, that is, the tumor labeling index, progesterone receptors, the degree of involvement of the lymph nodes in he area, the size of the tumor, etc. The second, extrinsic factors, relate to type and adequacy of treatment. The presentation demonstrates that the most critical factors in determining failure and patterns of failure are the intrinsic factors, that is, histologic grade tumor labeling index, number of nodes involved, progesterone receptors and size, and that the adequacy of treatment affects failure and patterns of failure in patients treated. This paper shows that adequate radiation reduces local recurrence and, consequently, increases the survival rate; it also demonstrates that inadequate radiation will lead to increased local recurrence and decreased survival. The factors involved in determining the adequacy of irradiation are discussed.

Breast Neoplasms↗
PubMed1985

Measuring and interpreting increases in probing depth and attachment loss.

Increases in probing depth and attachment level measurements are used by clinicians and clinical scientists for assessing the periodontal status and/or change in status of patients. Interpretation of these measurements has implications with respect to our understanding of periodontal disease, treatment of patients and the implementation of clinical investigations. Measurements of probing depths and attachment loss were made on 204 teeth in 34 patients. The measurements were repeated after short periods of time by different examiners as well as the same examiners. Using these data, sensitivities and specificities of several potential diagnostic thresholds were calculated. It is concluded that observing an increase of probing depth greater than 1 mm serves as a diagnostic test with high sensitivity and specificity.

Epithelial Attachment↗
PubMed1975

Suppression of bacterial growth and ammonia formation by citrate buffer in urine collected in ileal loop receptacles.

Bacterial growth in urine collected in ileal loop receptacles is greatly suppressed by the presence of 5 to 10 ml. 1-M. citrate buffer, pH 4. The suppression of bacterial growth by the citrate buffer prevents the formation of ammonia and perhaps other noxious metabolites whic are believed responsible for the irritation and inflammation of the skin exposed to infected urine. The citrate buffer is placed in the ileal loop receptacle at the beginning of each urine collection period.

Ammonia↗