Biomedical subjects

J R Breaux

Publications and source records attributed to J R Breaux.

3 recordsLinked to original sources

PubMed1989

Adaptability of endothelial orientation to blood flow dynamics--a morphologic analysis.

Vascular endothelium has a certain specificity in its anatomical orientation. The long axis of the endothelial cell and the shingle effect of cell process overlapping is always oriented parallel to the direction of blood flow. To determine whether this specific anatomical orientation would be maintained when the direction of blood flow was altered, twenty ilio-femoral vein segments and twenty vascular patches of carotid artery and jugular vein were studied. Valvulotomised ilio-femoral vein segments (n = 20) were interposed into adjacent arteries in a non-reversed fashion (the direction blood flow is reversed to the cell process overlapping). One centimeter-square carotid artery and jugular vein patches (n = 20) were rotated 90 degrees (endothelial cell orientation is perpendicular to the direction of blood flow). Reversal of endothelial cell overlapping to complement the complete reversal of the direction of blood flow exists in the vein graft through re-endothelialisation and endothelial reorientation. The process of endothelial reversal occurred in stages (endothelial cell process retraction, interdigitation, complete reversal) and was completed within 8-16 days. In the vascular patch, endothelial re-orientation occurred in 8 days through cell re-orientation and replacement. Mitosis was not encountered in either study. This report highlights certain functions and the adaptive capability of endothelial cells to complement the direction of blood flow.

Adaptation, Physiological↗

PubMed1988

Chylothorax causing reversible T-cell depletion.

Study of a patient with traumatic chylothorax after blunt chest trauma defines the changes in cellular immunocompetence during nonoperative management and emphasizes the importance of defining these parameters in addition to documenting the effects of metabolic deterioration.

Adult↗

PubMedDate not supplied

Adenocarcinoma of the stomach: a review of 35 years and 1,710 cases.

The records of 1,710 patients with adenocarcinoma of the stomach treated at Charity Hospital over a 35-year period were reviewed to note any trends which might help in understanding the decreasing incidence and poor prognosis of the disease. The yearly number of gastric cancer patients has dropped from 234/100,000 in the 1950's to 195/100,000 in the 1960's to 108/100,000 patients in the last decade. The percentage of affected white males is decreasing at a rate equal to the increasing frequency of black female patients, while the ratios for black males and white females remain constant. The median age rose from 61.5 years to 66 years over the study period. The operability rate decreased from 82.4% to 72.8% and the resectability rate was 49%. Subtotal gastrectomy was the most common procedure, but radical subtotal gastrectomy gave the best 5-year survival. There are fewer lesions of the antrum today, but the highest number of 5-year survivors had antral lesions. Long-term survival of patients with lesions of the cardia improved from zero in the first 25 years to 14% in the last decade. For the last 2 decades, patients with stage III and IV lesions comprised one-half of the 5-year survivors. Our overall 5-year survival was 7.9%, but in the last decade it was 8.9%. Our 5-year survival for all patients who underwent a resection was 17.9%, but increased to 24.8% for the last decade. These improvements, in combination with a decrease in incidence, have dropped the overall mortality from gastric cancer.

Adenocarcinoma↗