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Biomedical subjects

J R Clifford

Publications and source records attributed to J R Clifford.

9 recordsLinked to original sources
PubMed1977

Safety of mini-dose heparin administration for neurosurgical patients.

A course of small doses of heparin given subcutaneously before and after elective operations has been reported to reduce the incidence of deep venous thrombosis and pulmonary embolism in general surgical patients. To test the safety of mini-dose heparin for neurosurgical patients, mini-dose heparin was used for 150 adult patients undergoing elective neurosurgical procedures. No operative complications were thought to be related to heparin administration. Postoperatively, there were four wound seromas, two hematomas, and one non-fatal pulmonary embolus. Seven patients died postoperatively, of whom five had no evidence of pulmonary embolus. Although no conclusions were drawn as to the effectiveness of mini-dose heparin in preventing deep venous thrombosis or pulmonary emboli, it was believed that the method could be used safely and without fear of increased intracranial or intraspinal bleeding for neurosurgical patients.

Heparin↗
PubMed1976

Comparison of radionuclide scans with computer-assisted tomography in diagnosis of intracranial disease.

Radionuclide brain scans were compared with computer-assisted tomography (CAT) for the diagnosis of intracranial disorders in 297 patients. The diagnosis was confirmed in 281 patients who formed the population for the study. The radionuclide scan was false positive for 12 patients (3.9 percent) and false negative for eight (2.6 percent). The CAT was false positive for three patients (1 percent) and false negative for one (0.3 percent). In the 133 patients in whom both tests were negative, no evidence of central nervous system pathology has been found during the 6 to 18 month follow-up. Brain tumors and intracerebral hemorrhage are more readily detectable with CAT.

Brain Diseases↗