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J R Cowley

Publications and source records attributed to J R Cowley.

2 recordsLinked to original sources
PubMed1979

Isobaric gas counterdiffusion in rabbit eye.

The superficial isobaric gas counterdiffusion phenomenon, which produces dermal lesions and lethal gas embolism, was investigated at sea level and 2 ATA for effects on the eye of the New Zealand White rabbit. The animals breathed an N2O-O2 mixture by mask and were surrounded by a He environment. There was no gas lesion formation in the conjunctiva or cornea and no gas bubble formation in the anterior compartment of the eye in any of the experimental animals, even at the maximal 8-h exposure. In contrast to the eye, the skin of these animals showed progressive gas-filled lesions after 3 h at 1 ATA. Reasons for the relative insensitivity of the structures of the eye to the counter-diffusion process are discussed.

Animals↗
PubMed1979

Subcutaneous tissue gas space pressure during superficial isobaric counterdiffusion.

Changes in subcutaneous tissue pressure caused by N2O-He, 1-ATA isobaric counterdiffusion gas phase development were measured. Only the ears of New Zealand White rabbits were subjected to counterdiffusion. The rabbits breathed a mixture of 80% N2O-20% O2 while their ears alone were surrounded by He and the rest of their bodies continued to be surrounded by air. Subcutaneous pressure changes were transmitted to the transducer-recorded system via a fluid-filled subcutaneous needle. When the gas phase developed in subcutaneous tissue, pressure rose and a maximum pressure (Pmax) was reached. Pmax in the counterdiffused ear was 48 +/- 10 (SD) Torr, and mean time to reach Pmax was 75 +/- 10 (SD) min. The findings are discussed in relation to the pathological processes of isobaric inert gas counterdiffusion.

Animals↗